Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Project Management Jobs in South Dakota

Sort By: Relevance

$100K - $125K *

Manage a team of medical writers to develop impactful scientific content, ensuring accuracy and compliance. Collaborate with clients and cross-functional teams to drive medical strategies and delivera...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $125K *

Shape the future of organizational change by developing strategies, managing transitions, and driving transformation initiatives. Collaborate with teams to enhance productivity and ensure successful i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $150K *

Drive financial strategy by owning planning, forecasting, and analysis. Collaborate with leadership to provide insights that inform decisions, while building robust models in Excel to guide revenue an...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$135K - $160K *

Accelerate operational excellence by leading continuous improvement initiatives across service organizations. Drive quality, safety, and efficiency while optimizing spare parts and enhancing service p...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$170K - $220K *

Lead continuous improvement initiatives across QSR operations, driving cultural transformation and operational excellence. Manage CI strategies, develop leaders, and ensure alignment with enterprise g...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$160K - $175K *

Lead strategic initiatives to enhance customer success for high-value enterprise accounts, fostering long-lasting partnerships, driving engagement, and optimizing retention while managing a high-perfo...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$135K - $202K *

Drive product operations excellence by leading cross-functional teams, enhancing AI integration, and optimizing UX design to ensure a seamless product development lifecycle that empowers rapid, high-q...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Join a dynamic team as a senior leader, driving client relationships and revenue growth in lead-generation sectors. You'll manage a diverse portfolio, ensuring lead quality and speed while leveraging...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Unlock your potential as a Program Manager, leading federal service contracts and driving operational excellence. Collaborate with teams to ensure quality delivery, financial performance, and customer...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$165K - $185K *

Lead the execution of AI-enabled clinical informatics initiatives, focusing on Ambient AI Scribe capabilities. Drive program delivery, align stakeholders, and enhance clinical workflows to improve hea...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$163K - $261K *

Shape the future of electrification services by leading operations across the West U.S. region, driving performance excellence, and managing nationwide digital automation initiatives while advancing r...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$150K - $185K *

Champion the development of enterprise IT Financial Management, enhancing transparency in technology investments and enabling informed decision-making across the organization. Lead cross-functional co...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Manage and lead field-based medical teams, ensuring client delivery and team performance while fostering scientific engagement and program growth. Collaborate with cross-functional teams to achieve st...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $105K *

Manage and oversee multiple medical communications projects, ensuring timely delivery and operational excellence while collaborating with cross-functional teams and clients to drive impactful healthca...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $200K *

Lead the charge in developing integrated media strategies and client partnerships across pharmaceutical and life sciences accounts, driving business growth and ensuring exceptional delivery and client...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$115K - $150K *

Join a team that's dedicated to guiding recovery efforts post-disaster. Lead a multi-disciplinary team, leveraging your expertise in FEMA programs to support local governments through complex recovery...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Business Services

$150K - $180K *

Transform enterprise data into valuable insights while leading AI-powered product strategies. Drive cross-functional collaboration to deliver secure, innovative, and measurable data capabilities that...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $122K *

Take ownership of financial planning and analysis for G&A expenses, driving insights and reporting for senior leadership. Collaborate with teams to enhance budgeting, forecasting, and variance analysi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $150K *

Analyze and optimize customer journeys from signup to paid conversion, leveraging data insights to drive growth strategies. Collaborate across teams to enhance product decisions and influence market p...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $130K *

Contribute to project success by coordinating activities, maintaining documentation, and supporting delivery. Collaborate with experienced teams to enhance your project management skills and manage co...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$164K - $246K *

Transform the future of legal content by leading a global team to drive strategy, quality, and innovation in data collections. Own the end-to-end portfolio management, ensuring competitive, high-quali...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$170K - $180K *

Manage the product line of a flagship revenue integrity system, overseeing operations, feature development, and client communication to enhance product success while leading a dedicated team in a fast...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$144K - $189K *

Unlock potential by leading product innovation in clinical genomics. Shape tools for case management and data workflows, ensuring efficiency and quality while collaborating with lab directors and engi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join us to drive product strategy and vision for finance functions, optimizing Record to Report and FP&A processes. Collaborate with cross-functional teams to enhance financial systems and ensure comp...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$130K - $160K *

Unlock integrated marketing strategies to drive growth through data-driven campaigns, digital activation, and thought leadership, ensuring alignment with sales and operational goals for measurable bus...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.