Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Principal Business Technology Product Manager
$131K - $176K *
Shape the future of sales excellence by owning end-to-end seller experiences. You’ll optimize workflows, create impactful solutions, and directly influence our revenue systems through innovative produ...
Reposted 3 weeks ago
Director, Marketing Operations
$150K - $180K *
Lead the charge in optimizing marketing operations to drive developer adoption, pipeline growth, and revenue. Oversee systems, processes, and insights while collaborating with cross-functional teams t...
1 week ago
Business Continuity and Risk Management Director
$195K - $215K *
Join a dedicated team to shape enterprise strategies in business continuity and risk management while driving operational resilience across the organization. Leverage your expertise to influence decis...
Reposted 1 month ago
Senior Director, Revenue Operations
$170K - $195K *
Join a dynamic team as you lead Revenue Operations, driving strategy and execution for sales and renewals. Collaborate across departments to enhance processes, optimize technology, and ensure accurate...
Yesterday
$110K - $130K *
Grow your career with a hands-on marketing leadership role that drives lead generation through strategic content, vendor management, and budget oversight. Collaborate closely with sales to translate i...
Reposted 1 month ago
Sr. Clinical Project Manager - 175709
$165K - $175K *
Join a team that's leading global clinical trials across diverse therapeutic areas. Drive project execution, mentor teams, and ensure milestones are met while collaborating with stakeholders to achiev...
4 days ago
Senior Director, Commercial Operations
$215K - $235K *
Pioneer comprehensive commercial operations by designing, implementing, and optimizing pricing and deal negotiation processes. Drive ongoing analytics and continuous improvement, ensuring success in a...
Reposted 3 weeks ago
$80K - $95K *
Lead project coordination efforts by ensuring effective communication and management of materials, schedules, and documentation. Collaborate with teams to streamline processes and enhance project effi...
1 week ago
Traveling Project Manager – Mission Critical
$125K - $200K *
Champion large-scale, complex data center projects from preconstruction to closeout, ensuring budget, schedule, quality, and safety while navigating fast-paced environments and collaborating with dive...
4 weeks ago
Director, HR Business Partner - Product and Engineering
$150K - $215K *
Collaborate with senior leaders to design and implement global HR strategies, driving organizational performance and employee engagement while leading a team of HR professionals in a dynamic environme...
1 week ago
$105K - $176K *
Lead the charge in tax compliance and provision management, overseeing federal, state, and local returns. Collaborate cross-functionally to ensure timely filings and support tax strategies for busines...
3 weeks ago
$150K - $180K *
Lead the charge in transforming partner data operations and integrations, ensuring efficient case resolution and proactive partner enablement. Drive automation, establish standards, and foster a produ...
1 week ago
Principal Design Program Manager, International Packaging
$120K - $145K *
Lead the charge in shaping global healthcare packaging design. As a Principal Design Program Manager, you'll establish frameworks and standards, drive strategic decisions, and ensure seamless collabor...
2 weeks ago
$95K - $115K *
Champion the successful delivery of projects and technology initiatives by coordinating cross-functional teams and managing risks, ensuring timely and high-quality outcomes that align with business ob...
2 weeks ago
$140K - $190K *
Take ownership of defining and operationalizing a customer ROI framework across teams, fostering strategic growth initiatives through measurable value outcomes while enabling effective customer engage...
Reposted 1 month ago
Project Manager, OSP Construction & Engineering
$77K - $126K *
Take ownership of managing construction projects, ensuring timely, on-budget delivery while collaborating with vendors and adhering to guidelines. Drive process improvements and maintain comprehensive...
3 days ago
Senior Manager, Transaction Advisory
$500K+*
Lead the execution of carbon transaction advisory across LAC countries, managing senior government relationships and developing commercialization strategies to support forest protection initiatives an...
Yesterday
Senior Manager, Software Engineering
$180K - $240K *
Empower teams to innovate in residential construction software by leading high-performing engineering groups, fostering Agile practices, and enhancing project management for builders and homeowners al...
2 weeks ago
Program Manager - Healthcare Transformation
$140K - $165K *
Lead the charge in managing strategic healthcare programs, enhancing integrated delivery systems through innovative project solutions and stakeholder engagement while mentoring junior analysts and ove...
1 month ago
Senior Director I, Umbrella Product Management
$160K - $190K *
Join a team that's redefining the Umbrella line of business by overseeing P&L, driving innovative strategies, and collaborating across departments to achieve profitable growth and enhance customer sat...
5 days ago
Senior Manager, Clinical Operations
$136K - $171K *
Pioneer clinical trial excellence by leading operational planning and execution. Collaborate cross-functionally to ensure compliance, quality, and timely delivery of clinical studies while mentoring j...
4 days ago
Senior Manager, Global Deal Desk
$125K - $150K *
Champion scalable deal operations by leading the Global Deal Desk, optimizing complex agreements across sales, finance, and legal. Drive AI integration to enhance workflows and ensure compliance while...
1 week ago
Group Product Manager, Foundations & Intelligence
$152K - $190K *
Lead the charge in product strategy and outcomes across diverse portfolios, connecting customer needs with business objectives. Develop and mentor a team of Product Managers while driving impactful pa...
3 weeks ago
Senior Project Manager (City and County)
$130K - $154K *
Lead complex projects to enhance organizational efficiency, manage timelines, and coordinate cross-functional teams. Drive strategic goals while ensuring compliance and fostering strong stakeholder re...
2 weeks ago
Proposals and Contracts Manager
$85K - $105K *
Lead the charge in managing proposals and contracts within a dynamic CRO environment. Collaborate with cross-functional teams to drive strategic business development and ensure compliance with client...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.