Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$125K - $150K *

Unlock your potential to lead programmatic strategies, shape best practices, and empower teams to excel in the DSP landscape. Collaborate with stakeholders and transform our approach to digital advert...

United StatesRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $160K *

Contribute to the evolution of data-driven healthcare products, shaping strategy and execution. Collaborate with cross-functional teams to deliver AI-enabled solutions that enhance clinical outcomes a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in shaping product strategy and execution for a key applications portfolio, driving innovation and growth through AI integration while mentoring a high-performing team in a dynamic hea...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$106K - $177K *

Unlock potential by leading cross-functional teams to shape product strategy, drive growth, and enhance customer value through data-driven insights and innovative solutions across the full product lif...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$135K - $160K *

Advance financial operations by managing project finance teams, enhancing reporting processes, and supporting month-end close activities. Collaborate with stakeholders to ensure accurate revenue recog...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Advance your career by managing financial operations for project teams, enhancing reporting accuracy, and leading financial analysis to support clinical trials and strategic decision-making...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$86K - $145K *

Optimize project delivery by managing timelines and logistics for creative campaigns, ensuring collaboration and clarity. Thrive in a dynamic environment, supporting a skilled team while enhancing you...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$115K - $140K *

Join a team that's driving innovation in technical program management by leading complex engineering initiatives, enhancing cross-functional collaboration, and improving team productivity in a dynamic...

United StatesRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$110K - $130K *

Unlock potential by leading product vision and strategy, driving customer insights to align with business goals. Collaborate across teams to deliver innovative solutions, ensuring impactful outcomes f...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$94K - $151K *

Drive your career with this pivotal Product Manager role, where you'll bridge business needs and technology in a large-scale retail environment. Enhance product outcomes through strategic partnerships...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Empower the design process by leading in-house teams and managing consultants. Drive healthcare and commercial projects from concept to construction documents while establishing design standards and e...

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $185K *

Develop innovative healthcare products by collaborating with cross-functional teams. Leverage your technical expertise to enhance platform capabilities and deliver impactful solutions that improve pat...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Advance organizational change initiatives by leading Oracle Cloud transformations. Collaborate with stakeholders to ensure successful adoption through strategic planning, training, and communication...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Staffing

$126K - $168K *

Lead the charge in shaping and executing product strategy for B2B learning solutions, driving innovation and market impact while collaborating with cross-functional teams to deliver high-quality produ...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $200K *

Champion large-scale enterprise application initiatives, leading Agile teams to drive digital transformation, manage program execution, and ensure alignment with strategic objectives while fostering c...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate your career by managing diverse EV projects, ensuring successful delivery through collaboration, strategic planning, and effective stakeholder engagement. Drive project excellence while naviga...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $200K *

Optimize technology risk management across the enterprise by leading proactive assessments, ensuring alignment with regulatory standards, and embedding risk insights into decision-making for cloud, cy...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Join a team that's dedicated to optimizing project planning and cost control for renewable energy initiatives. Lead efforts in scheduling, compliance, and reporting to ensure project success from ince...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$124K - $208K *

Champion financial leadership across diverse Electrical Power Transmission portfolios, driving profitability, cash flow, and execution discipline. Collaborate with cross-functional teams to enhance pr...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Business Services

$136K - $220K *

Unlock project management excellence in Global Regulatory Affairs, driving timelines and compliance for drug submissions. Collaborate cross-functionally to ensure accurate documentation and effective...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$99K - $168K *

Lead a dynamic team in defining and executing product strategy for budgeting services. Collaborate cross-functionally to deliver innovative solutions that enhance customer satisfaction and drive growt...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Lead the charge in managing IT delivery projects, ensuring timely execution and quality outcomes while collaborating with cross-functional teams and stakeholders to drive success across multiple initi...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$137K - $172K *

Shape the future of technology delivery by leading complex, cross-functional programs that drive business value. Oversee strategic initiatives, ensuring excellence in execution, client satisfaction, a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Optimize governance and risk management at scale, guiding compliance and security strategy while collaborating across teams to enhance our organizational resilience as we expand into new markets and n...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $110K *

Lead core banking system conversions for credit unions, ensuring seamless project delivery through effective stakeholder communication, data migration, and interface integration, while managing risks...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.