Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Director, Project Management Jobs in Pennsylvania

Sort By: Relevance

$181K - $245K *

Elevate your career by leading lifecycle marketing strategies that enhance customer engagement, retention, and monetization. Drive impactful programs while managing a high-performing team and collabor...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$130K - $211K *

Join a dynamic team to lead large-scale capital construction projects, ensuring safety, quality, and budget adherence. Oversee field execution from design to completion, managing contractors and foste...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Champion the enhancement of Third Party Risk governance and frameworks, ensuring effective management and compliance across the organization. Collaborate with stakeholders to strengthen risk culture a...

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Transform your career by leading a dynamic production team, driving safety, quality, and continuous improvement initiatives while ensuring customer satisfaction and operational efficiency in a fast-pa...

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$110K - $130K *

Launch impactful B2B events by developing strategies, managing budgets, and executing flawless experiences. Collaborate with marketing leaders to enhance brand presence and foster relationships throug...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $189K *

Empower our team as a Product Owner, leading strategic execution and collaboration with engineering to define features, manage backlogs, and ensure successful delivery of mission-critical software sol...

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$149K - $237K *

Lead transformative finance operations to optimize efficiency, enhance controls, and drive data-driven decision support. Collaborate across functions to modernize processes, develop best practices, an...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$145K - $175K *

Unlock potential by serving as a strategic advisor to enterprise clients, guiding them through complex stakeholder environments with predictive intelligence and data-driven insights to drive impactful...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Media

$110K - $130K *

Lead the charge in transforming complex genomic data into compelling narratives that resonate with audiences, driving engagement across diverse channels while collaborating with cross-functional teams...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Join a team that's driving business development across a diverse portfolio, managing accounts, generating leads, and closing sales. You'll engage with clients to deliver customized solutions while ach...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$177K - $221K *

Lead the development and execution of global CMC regulatory strategies to support clinical trials and market applications, ensuring compliance with regulatory requirements throughout the product lifec...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$140K - $170K *

Lead the execution of large-scale infrastructure projects, managing integration for acquired entities, coordinating cross-functional teams, and ensuring timely delivery aligned with architecture stand...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Transform the internal IT landscape by managing employee support, systems administration, and infrastructure scalability. Drive automation and security initiatives while enhancing user experience in a...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Aerospace & Defense

$105K - $145K *

Collaborate with cross-functional teams to design integrated solutions that enhance user experience, leveraging AI tools and a design system to create cohesive workflows and drive product value in a B...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$190K - $237K *

Optimize sourcing strategies and procurement processes for clinical operations, ensuring effective vendor management and governance across global clinical trials. Collaborate with cross-functional tea...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$124K - $280K *

Drive success by leading Guidewire development for insurance clients, overseeing technical design, configuration, and testing. Collaborate with stakeholders to enhance policy, claims, and billing oper...

6 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$124K - $280K *

Champion your career by leading Guidewire development for insurance clients. Drive technical design, coach teams, and ensure delivery excellence while transforming policy, claims, and billing operatio...

6 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$150K - $180K *

Innovate product management across a diverse SaaS portfolio, leading teams to enhance strategy and execution. Collaborate with executives to drive growth and operational excellence in global markets...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$88K - $105K *

Empower your career by leading the delivery of IT services to schools and clients. Manage teams, foster client relationships, and drive operational excellence in a dynamic environment with continuous...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Drive pricing strategy and analytics for power distribution products, ensuring competitive market positioning and margin protection. Collaborate cross-functionally to enhance quoting processes and del...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$220K - $340K *

Champion construction delivery excellence across global data center sites, managing GC performance and budgets of $25M+. Lead strategy, negotiate contracts, and represent construction risks to executi...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$168K - $285K *

Shape the future of financial strategy by leading R&D finance, partnering with executives to drive investment decisions, optimize spending, and enhance forecasting accuracy in a dynamic, AI-driven env...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Lead the charge in product innovation by managing the full lifecycle from ideation to launch. Collaborate with cross-functional teams to align technical and business goals, ensuring successful product...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$96K - $144K *

Take ownership of contract management by drafting, negotiating, and administering agreements with key customers. Collaborate with cross-functional teams to ensure compliance and operational efficiency...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$184K - $200K *

Unlock potential by driving the vision and strategy for innovative products that empower independent candidates and enhance user engagement. Collaborate with cross-functional teams to create scalable...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.