Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Director, Project Management Jobs in Pennsylvania

Sort By: Relevance

$155K - $410K *

Lead strategic initiatives in alliance management and sales enablement, focusing on Microsoft Dynamics 365. Drive revenue growth, foster client relationships, and mentor teams to achieve market expans...

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$125K - $150K *

Unlock growth by leading federal capture efforts, developing strategies, and securing contracts. Collaborate with cross-functional teams to align customer needs with capabilities, ensuring compliance...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$155K - $410K *

Champion alliance strategy and sales enablement initiatives, driving revenue growth through executive relationships and market insights. Lead cross-functional teams to translate vision into actionable...

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$155K - $410K *

Champion strategic alliances and sales enablement initiatives to drive revenue growth. Lead business development, mentor future leaders, and collaborate across teams to connect technology with client...

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$160K - $215K *

Elevate business integrity by spearheading internal audits, enhancing risk assessments, and streamlining processes. Collaborate cross-functionally to ensure robust controls, compliance, and effective...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Transportation

$190K - $200K *

Elevate operational excellence by leading transformation initiatives and optimizing Shared Services. Collaborate with senior leaders to drive measurable improvements in productivity, cost efficiency...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$167K - $183K *

Lead the charge in optimizing G&A technology solutions, enhancing business processes through AI and automation. Collaborate with stakeholders to drive efficiency and compliance, ensuring scalable grow...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in managing a software team, driving development of innovative medical device applications while ensuring compliance with regulations and agile practices...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$267K - $401K *

Lead the charge in defining product strategy and execution for Developer Experience and AI initiatives, ensuring secure interactions and impactful outcomes across technical domains while collaborating...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$190K - $240K *

Accelerate progress at strategic partnerships in the NAMER region by identifying, onboarding, and managing key partners. Drive revenue growth through collaboration, enablement, and relationship manage...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Elevate your career by driving product delivery excellence across teams. You'll ensure timely resolution of client requests and bugs, coordinating efforts between Product, Engineering, and Customer Ex...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

$67K - $102K *

Empower multidisciplinary design projects by providing technical leadership and coordination. Ensure compliance with specifications and quality objectives while managing engineering activities through...

Reposted today

  •   5 - 7 years exp.  •   Technical Services

$105K - $135K *

Transform product vision into reality by driving execution and collaboration across teams. Leverage data and AI to enhance risk data accessibility, ensuring customers can act swiftly and confidently o...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Lead the charge in proactive schedule planning and risk mitigation for Mission Critical projects, ensuring optimal performance through expert analysis, recovery strategies, and collaboration with proj...

4 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Champion the growth of a dedicated therapy team, enhancing patient care and clinical outcomes for adults and geriatrics. Lead with mentorship and support, fostering a collaborative environment while d...

Today

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Lead the charge in driving strategic sales initiatives, managing key accounts, and fostering long-term partnerships. Collaborate with cross-functional teams to identify growth opportunities and delive...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$160K - $200K *

Shape the future of product strategy by leading a high-performing team, driving innovation, and ensuring alignment across operations and technology to deliver exceptional customer value and measurable...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$115K - $140K *

Engage as an experienced implementation leader managing complex client onboarding and execution of digital banking solutions. Collaborate across teams to drive project success, enhance operational eff...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Grow your career with a pivotal role in patient safety management, supporting event reporting and analysis across multiple sites. Collaborate with leaders and frontline staff to enhance safety practic...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Drive new business growth by engaging with mid-market and enterprise pharma clients. Lead consultative sales cycles, build executive relationships, and architect transformative solutions that enhance...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $165K *

Join a team that's redefining hedge accounting and financial risk management. Collaborate with clients and experts to navigate complex strategies, enhance advisory capabilities, and drive impactful so...

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$130K - $155K *

Accelerate progress at the forefront of cloud innovation by leading teams to design, build, and enhance a robust cloud platform. Drive operational excellence, implement cutting-edge observability arch...

4 weeks ago

  •   11 - 15 years exp.  •   Technical Services

$135K - $160K *

Accelerate progress at the forefront of the US Gastrointestinal business, driving strategic initiatives and enabling executive leadership to achieve measurable outcomes while enhancing customer relati...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$181K - $245K *

Elevate your career by leading lifecycle marketing strategies that enhance customer engagement, retention, and monetization. Drive impactful programs while managing a high-performing team and collabor...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$130K - $211K *

Join a dynamic team to lead large-scale capital construction projects, ensuring safety, quality, and budget adherence. Oversee field execution from design to completion, managing contractors and foste...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.