Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Director, Project Management Jobs in Pennsylvania

Sort By: Relevance

$286K - $457K *

Transform client relationships and lead mega projects by managing budgets, schedules, and resources. Collaborate with leadership to achieve business objectives while mentoring teams and pursuing new o...

3 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$138K - $150K *

Drive corporate growth by managing strategic projects and M&A initiatives. Collaborate with cross-functional teams to analyze markets, evaluate targets, and present business cases, ensuring alignment...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $150K *

Drive strategic growth by managing corporate portfolio and M&A initiatives, focusing on digital health and emerging technologies. Collaborate with cross-functional teams to identify opportunities and...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $150K *

Analyze and manage corporate portfolio growth through strategic projects and business development. Collaborate with cross-functional teams to drive M&A initiatives and evaluate market opportunities, e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Lead the evolution of our GTM Systems Architecture, enhancing Salesforce and its tech stack for AI-native workflows. Collaborate with cross-functional teams to build a trusted data foundation and driv...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Join a team that's dedicated to leading a multidisciplinary engineering department, fostering collaboration, and driving project success while mentoring engineers across various disciplines in a dynam...

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$185K - $256K *

Elevate the market growth strategy for biologics research, driving software adoption and AI use cases. Collaborate with global teams and engage with industry leaders to shape the future of molecular t...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$152K - $283K *

Elevate enterprise data strategy by engineering reliable, compliant data products. Lead data governance and innovation to enhance data-driven decision-making, ensuring high-quality data delivery acros...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in optimizing IT operations and service delivery, ensuring secure, reliable technology systems. Drive team performance and continuous improvement while collaborating with business lead...

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$163K - $224K *

Join a team that's redefining People Operations by leading global service delivery, enhancing employee experiences, and driving operational excellence across Talent Acquisition and People processes fo...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$195K - $325K *

Shape the future of AI solutions across diverse business units, driving impactful insights and strategic alignment. Collaborate with teams to identify high-value opportunities and ensure successful ex...

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's shaping the future of financial management in R&D. Drive project budgets, forecasts, and insights while collaborating with cross-functional teams to ensure financial efficiency and...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$105K - $125K *

Lead technology operations for global teams, optimizing systems and support. Collaborate on strategic AI solutions, ensuring compliance and enhancing workflows. Drive efficiency and innovation in a dy...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Transform complex organizational dynamics by designing strategic communication and operational frameworks for a large product team. Lead initiatives that align with overarching company goals, ensuring...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$110K - $130K *

Elevate your career by leading Infor M3 ERP implementations. Drive project success through strategic planning, client management, and cross-functional collaboration while ensuring timely delivery and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $119K *

Drive the commissioning of renewable energy projects, managing teams to ensure all testing and installation meets safety standards and project goals. Collaborate across functions for seamless project...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$130K - $160K *

Lead the charge in project controls management, ensuring effective cost, schedule, and risk oversight across diverse programs. Collaborate with teams to deliver actionable insights that drive successf...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Transform complex customer implementations into seamless successes by owning the delivery lifecycle, driving technical discussions, and ensuring stakeholder satisfaction from kickoff to go-live. Your...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$162K - $202K *

Shape the future of federal project development while fostering key relationships and driving business growth in the nuclear and energy sectors. Collaborate with senior leaders to enhance customer sat...

Reposted yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$160K - $180K *

Elevate customer success by managing strategic federal programs, ensuring seamless implementation and adoption of innovative solutions. Collaborate with stakeholders to drive project execution and enh...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$149K - $224K *

Drive analytics excellence by leading a team to deliver impactful insights, enhance reporting capabilities, and support strategic decision-making across diverse business functions. Foster collaboratio...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$69K - $104K *

Lead the charge in optimizing workspace utilization through effective space planning and project management. Collaborate with diverse stakeholders to enhance government facilities, ensuring efficiency...

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$202K - $289K *

Champion growth in environmental services by leading business development, managing complex projects, and fostering client relationships in the power industry. Leverage your expertise to navigate regu...

United StatesRemote

1 week ago

  •   15+ years exp.  •   Technical Services

$209K - $349K *

Take ownership of engineering strategy and delivery for a major technology integration, ensuring modernization and seamless client transitions while leading a high-performing team across multiple tech...

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$79K - $94K *

Optimize training and workflow processes by leading program development, mentoring trainers, and collaborating with stakeholders to enhance provider experiences and operational efficiency across Care...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.