Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$111K - $163K *

Join a team dedicated to driving successful IT project outcomes through effective management methodologies, ensuring on-time and on-budget completion while aligning with business goals and fostering c...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $135K *

Lead the charge in driving strategic project delivery across multiple squads, ensuring alignment with business priorities and effective communication among stakeholders. Utilize program management exp...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$160K - $200K *

Lead the charge in optimizing top-of-funnel marketing operations, driving measurable pipeline growth through strategic planning, data governance, and team leadership. Collaborate with cross-functional...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$105K - $150K *

Lead product management for complex digital services, mentoring a team of Product Managers. Collaborate with stakeholders to define strategies, prioritize needs, and deliver impactful outcomes while f...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Help us lead complex capital projects by overseeing technical and operational management, ensuring timely delivery, and mentoring a talented team for excellence in bulk material handling and construct...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Drive your career with a dynamic team managing complex engineering projects in environmental restoration and land development. Lead multidisciplinary teams, ensure compliance, and deliver innovative s...

3 weeks ago

  •   15+ years exp.  •   Manufacturing & Automotive

$110K - $130K *

Lead strategic initiatives by managing complex projects from inception to launch. Collaborate across teams to implement new markets and contracts, ensuring compliance and operational readiness in a dy...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$117K - $189K *

Pioneer global Orexin development programs by driving project management efforts. Partner with the Global Team Leader to oversee cross-functional teams, manage critical activities, and ensure project...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$104K - $168K *

Elevate your career by leading transformative healthcare projects, guiding multidisciplinary teams, and fostering client relationships. Join a dynamic team to shape innovative environments and drive s...

4 days ago

  •   8 - 10 years exp.  •   Technical Services

$95K - $115K *

Lead high-profile healthcare projects, guiding multidisciplinary teams and fostering client relationships. Drive strategy, oversee design, and ensure project delivery while contributing to business de...

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Lead cross-functional teams to drive successful oncology clinical trials. Manage project lifecycle from start-up to closeout, ensuring quality outcomes and strategic alignment. Foster team excellence...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Champion project excellence by managing multiple global implementations, ensuring timely delivery and customer satisfaction while promoting best practices and continuous improvement throughout the pro...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Accelerate progress at the forefront of project management by leading HV breaker product execution, ensuring compliance, and driving collaborative success across teams and stakeholders to deliver impa...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Drive successful public-sector construction projects by managing scope, schedule, and budget while fostering strong client relationships and ensuring quality delivery from inception to closeout...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$85K - $102K *

Drive project success by managing client relationships and overseeing project execution from start to finish, ensuring timely delivery and quality outcomes while leading a dedicated team...

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Champion digital transformation by leading delivery teams in Salesforce projects, ensuring excellence in project management, client relationships, and issue resolution while mentoring consultants and...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$163K - $297K *

Champion the development and execution of innovative digital product strategies across EMEA, enhancing consumer experiences and driving key performance indicators in a high-growth e-commerce environme...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$103K - $181K *

Optimize document control processes by leading the Information Branch, ensuring accurate and accessible records management for a major industrial program while coordinating with various stakeholders a...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$126K - $162K *

Join a dynamic team to lead construction administration projects, ensuring seamless execution from design to closeout. Collaborate with stakeholders, manage client relations, and drive project success...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$135K - $160K *

Transform your career by leading cross-functional teams to drive drug development strategies. Collaborate with key stakeholders to ensure successful execution of integrated plans, manage risks, and de...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join a dynamic team to drive operational excellence across Business Units, ensuring accurate forecasting, insightful reporting, and effective execution. Collaborate closely with GMs to enhance perform...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$121K - $125K *

Join a team that's dedicated to enhancing community spaces by leading capital improvement and asset management projects across a diverse portfolio, ensuring safe and welcoming environments for residen...

2 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$80K - $95K *

Optimize project execution in global healthcare market research, managing timelines, budgets, and vendor relationships. Collaborate with multidisciplinary teams to ensure quality and compliance while...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$192K - $288K *

Lead strategic initiatives and operational excellence across R&D, partnering with executives to enhance pipeline delivery and drive AI innovation. Oversee workforce planning, budget management, and cr...

Pennsylvania, USRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$136K - $255K *

Drive program management excellence by aligning initiatives with corporate strategies, enhancing operational processes, and fostering stakeholder relationships to achieve continuous improvement and fi...

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.