Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Director, Project Management Jobs in Pennsylvania

Sort By: Relevance

$180K - $200K *

Reimagine security engineering leadership by guiding strategic initiatives across cloud and infrastructure security, enhancing detection engineering, and fostering collaboration to protect a multi-clo...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$185K - $255K *

Transform the financial engine of R&D by leading revenue strategies, pricing, and cost management. Collaborate with senior leaders to align short-term goals with long-term product vision, while buildi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$201K - $251K *

Lead strategic forecasting initiatives to drive decision-making in oncology. Collaborate with cross-functional teams to develop long-term models and communicate insights that shape product and portfol...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in developing and executing supply chain strategies that align with business objectives, fostering collaboration across teams to drive performance and deliver measurable value in a dyn...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$110K - $130K *

Lead the execution of complex client programs, ensuring timely delivery and budget adherence. Collaborate with cross-functional teams to drive accountability and clarity, while proactively managing ri...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$150K - $180K *

Lead the charge in transforming marketing operations through innovative MarTech solutions, driving student and partner success while optimizing efficiency across a multi-brand ecosystem. Own product s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Manage environmental engineering projects, lead field investigations, and oversee junior staff. Collaborate with clients to restore properties while ensuring compliance with regulations and delivering...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$185K - $256K *

Join a team that's redefining CMC strategies in life sciences. You'll engage with industry leaders, drive software adoption, and shape market narratives to enhance product lifecycle management and ope...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Empower strategic growth and operations by integrating cross-functional teams, aligning priorities, and driving initiatives to enhance study delivery and operational excellence in a dynamic environmen...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$192K - $288K *

Join us as a strategic partner in global clinical development operations, driving workforce planning, budget management, and continuous improvement initiatives. Collaborate with leadership to enhance...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$135K - $178K *

Transform data governance by leading initiatives that bridge legal compliance, data security, and technology operations. Drive innovative self-service workflows while ensuring compliance across divers...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$132K - $220K *

Lead the charge in managing Renewable Energy Hydro Projects, driving execution strategies to maximize performance, ensuring timely delivery, and fostering strong customer relationships while overseein...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$110K - $145K *

Shape the future of energy efficiency by leading complex client programs and strategic initiatives. Drive portfolio success through operational excellence, financial performance, and strong client rel...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Energy & Utilities

$188K - $282K *

Drive design excellence in fintech by leading a team to enhance payment, billing, and timekeeping solutions. Collaborate with cross-functional partners to shape user experiences that empower legal pro...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$232K - $290K *

Lead the charge in optimizing workforce operations and analytics for multi-condition health care services. Develop strategies for capacity planning, staffing, and analytics to drive efficiency and sup...

United StatesRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$130K - $160K *

Drive program success by coordinating cross-functional teams, managing reporting, and optimizing engagement strategies for a global enterprise account, ensuring alignment with client goals and employe...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$209K - $239K *

Empower the future of payments by leading product strategy and innovation. Collaborate with cross-functional teams to redefine money movement capabilities and drive transformational solutions in a dyn...

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $150K *

Shape impactful healthcare solutions by leveraging your Epic Professional Billing expertise. Collaborate with diverse teams to optimize systems, enhance workflows, and drive meaningful results for cli...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Shape and elevate business operations and account management, driving resource optimization and client satisfaction. Collaborate with leadership to enhance project delivery and expand client relations...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a team that's transforming distressed multifamily assets into thriving communities. You'll lead operational turnarounds, manage complex transitions, and implement strategic recovery plans to stab...

2 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$126K - $167K *

Transform your future by leading a dynamic team of electrical engineers in our Mission Critical Department. Elevate project outcomes while driving accountability, fostering growth, and cultivating inn...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $115K *

Accelerate progress at our organization by leading financial operations across diverse service lines. Collaborate with senior leaders to enhance profitability, manage budgets, and drive strategic grow...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $125K *

Manage complex HR projects from concept to implementation, ensuring timely delivery and alignment with strategic goals. Collaborate with cross-functional teams to drive project success and enhance emp...

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Join a team that's dedicated to innovating medical device technology. Lead the design and development of electrical hardware and firmware, ensuring compliance and reliability while mentoring future le...

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$88K - $105K *

Explore a leadership role in municipal engineering, managing impactful projects from planning to implementation while fostering client relationships and expanding services across communities in Wester...

1 week ago

  •   Less than 5 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.