Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Director, Project Management Jobs in Pennsylvania

Sort By: Relevance

$150K - $180K *

Drive impactful care delivery strategies by collaborating across teams to enhance patient access and operational efficiency in the GU portfolio. Shape scalable solutions that support adoption and opti...

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Innovate and enhance educator solutions by leading product management initiatives. Collaborate with cross-functional teams to identify customer needs and drive product development that aligns with str...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$137K - $235K *

Join a team that's transforming clinical and omics data into AI-ready assets. Lead the end-to-end data product lifecycle, ensuring quality and interoperability while mentoring junior engineers and col...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $160K *

Drive operational excellence by leading process and manufacturing engineering initiatives. Collaborate across teams to enhance efficiency, product quality, and scalability while fostering a culture of...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Elevate manufacturing excellence by leading operations for Breakers & Modules. Drive performance, inspire teams, and optimize processes to deliver results in a fast-paced environment, shaping the futu...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Lead production operations to ensure efficient manufacturing while meeting safety, quality, and environmental standards. Drive team performance and strategic planning to achieve production goals and e...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Elevate your career by leading the strategy and delivery of a robust Salesforce ecosystem, driving business impact through innovative solutions and team development in a dynamic, global environment...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Innovate within a dynamic team, driving impactful projects and solutions that enhance operational efficiency and foster growth across multiple departments. Your expertise will shape strategic initiati...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$76K - $115K *

Join a team that's shaping the future of customer education through innovative instructional design. Leverage your expertise to create engaging learning experiences that empower users and drive succes...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$94K - $266K *

Join a team that's dedicated to delivering successful Workday implementations. Lead cross-functional teams, manage complex projects, and build strong client relationships while ensuring alignment betw...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$94K - $266K *

Help us lead complex Workday implementations, ensuring alignment across teams and delivering high-quality outcomes through proactive governance and risk management. Build trusted relationships with cl...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$95K - $115K *

Drive successful construction projects by managing all phases from planning to completion. Collaborate with stakeholders, ensure compliance, and maintain budgets while delivering quality results on ti...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$150K - $180K *

Join a team that drives strategic AMER Field Marketing initiatives, managing a skilled team to enhance pipeline growth. Lead data-driven marketing efforts across North America, LATAM, and the Public S...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$120K - $145K *

Explore innovative AI workflow solutions aimed at enhancing business processes. Collaborate with various teams to identify challenges, prototype solutions, and guide projects from conception to produc...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$146K - $269K *

Shape the future of enterprise software by leading multiple engineering teams, driving application development, and implementing best practices. Collaborate cross-functionally to enhance quality and s...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$130K - $160K *

Unlock the potential of global quoting processes by owning the end-to-end CPQ workflow. Drive innovation and efficiency through Salesforce integrations, leading implementation projects while enhancing...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$144K - $211K *

Drive engineering excellence by leading a high-performing team in implementing and scaling industrial control systems. Collaborate across functions to ensure reliable, maintainable solutions that supp...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$155K - $180K *

Drive successful delivery of complex, multi-year programs in a dynamic environment. Collaborate with cross-functional teams to manage scope, budget, and timelines while ensuring client satisfaction an...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Elevate your career by leading a team to enhance Oracle EPM Cloud applications. Drive stability, support, and governance while collaborating with Finance and Technology stakeholders to deliver impactf...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$125K - $150K *

Lead the charge in driving new business acquisition and expanding opportunities across Consumer Goods, Retail, and Travel sectors. Leverage industry expertise to build relationships and position as a...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Champion innovative solutions as a Senior Implementation Project Manager, leading complex software implementations and driving customer success through effective project management and collaboration a...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$108K - $130K *

Lead the charge in program management, overseeing strategic execution and resource allocation across technology domains. Collaborate with stakeholders to align business strategies with operational goa...

Yesterday

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$94K - $114K *

Support project risk management initiatives across various sectors, collaborating with stakeholders to identify, analyze, and mitigate risks. Lead qualitative and quantitative assessments to enhance p...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Technical Services

$190K - $228K *

Drive enterprise Quality and Regulatory governance for U.S. operations, ensuring compliance with FDA regulations and overseeing manufacturing quality in the therapeutic radiopharmaceutical sector whil...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$275K - $325K *

Lead the charge in building and managing a construction banking sector, driving strategy, partnerships, and product development while overseeing P&L and fostering key relationships to establish Flex a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.