Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Director, Project Management Jobs in Pennsylvania

Sort By: Relevance

$95K - $115K *

Drive your career with impactful water resources projects, managing teams and client relationships while overseeing planning and design. Leverage your expertise to enhance infrastructure and contribut...

4 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$90K - $110K *

Explore a pivotal role in managing diverse water resources projects, leading teams, and enhancing client relationships. Drive strategic initiatives for growth in the water/wastewater sector, ensuring...

4 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$95K - $115K *

Elevate your career by managing diverse water resources projects, leading teams, and fostering client relationships. Drive strategic initiatives for growth while ensuring project success through effec...

4 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$95K - $115K *

Drive impactful water resources projects by leading teams and managing client relationships. Leverage your engineering expertise to enhance infrastructure and contribute to strategic growth initiative...

4 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$95K - $115K *

Shape the future of water resources by managing diverse projects, leading teams, and fostering client relationships. Drive strategic initiatives for growth in water/wastewater engineering, ensuring su...

4 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$115K - $165K *

Lead the charge in shaping software product strategy and lifecycle for analytics solutions. Collaborate across teams to enhance user experience and drive measurable outcomes, ensuring alignment with c...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in multidisciplinary design delivery for data center projects, ensuring buildable, cost-effective designs from planning through construction. Collaborate with teams to meet tenant need...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$194K - $266K *

Champion patient engagement strategies by leading a dynamic team focused on optimizing recruitment and retention across clinical trials. Drive performance, enhance collaboration, and ensure successful...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Empower project success by managing all phases from design to completion, ensuring quality, safety, and customer satisfaction while leading a dynamic team in a fast-paced construction environment...

3 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$125K - $150K *

Lead and develop engineering teams focused on clinical data integration and insights. Drive the direction of data pipelines and ensure impactful, equitable health outcomes through effective collaborat...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by leading EHS initiatives across multi-site operations, ensuring safety and compliance through risk assessments, crisis management, and employee health programs. Collaborate with tea...

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$107K - $145K *

Drive growth by identifying and securing new business opportunities in risk management and medical education. Collaborate with teams to develop proposals, manage sales pipelines, and ensure alignment...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$298K - $340K *

Join a dynamic team to lead strategic statistical programming initiatives, ensuring top-quality deliverables and compliance across diverse clinical trials. Collaborate with cross-functional partners t...

United StatesRemote

Reposted 3 weeks ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$168K - $228K *

Transform global GxP Change Management processes by leading strategy, governance, and continuous improvement initiatives across the product lifecycle, ensuring effective risk-based changes and collabo...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead the charge in developing and executing product strategies that align with client needs and business objectives, driving innovation and collaboration across teams to enhance product offerings and...

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $215K *

Lead the charge in transforming supply chain technology strategies, driving innovation and operational excellence across S2P and O2C value streams. Collaborate with cross-functional teams to enhance d...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Elevate the delivery of Salesforce programs by leading end-to-end project management, ensuring compliance, and fostering collaboration across teams to enhance federal application modernization efforts...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$203K - $304K *

Champion innovative operational strategies in clinical research, driving excellence in bid defense meetings and proposal development. Collaborate with cross-functional teams to enhance study execution...

United StatesRemote

2 weeks ago

  •   15+ years exp.  •   Healthcare

$135K - $150K *

Champion growth by leading strategic business development initiatives, forging partnerships, and driving revenue expansion. Collaborate with executives to align goals and enhance market presence while...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Technical Services

$120K - $145K *

Unlock potential by driving technology initiatives that enhance operations, streamline processes, and improve data utilization across the organization, while leading tuck-in integrations and maximizin...

4 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $120K *

Accelerate product development by leading end-to-end processes, integrating advanced technologies, and driving outcomes across a suite of digital solutions for legal service operations, while ensuring...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$150K - $180K *

Drive product strategy and execution for a critical portfolio area, leading cross-functional teams to transform user insights into impactful software solutions while mentoring others and shaping platf...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$98K - $147K *

Lead project scheduling efforts for major capital initiatives, ensuring timely delivery and alignment with client goals. Collaborate with teams to analyze schedules, mitigate risks, and drive project...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$80K - $95K *

Shape the future of quality assurance by leading process improvement initiatives and managing a dedicated team to ensure high standards in production and compliance, while fostering a culture of safet...

2 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$100K - $130K *

Champion innovative methodologies in medical communications, leading Delphi studies and expert panels. Drive strategic insights and deliver scientifically rigorous findings to support clinical develop...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.