Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$100K - $120K *

Lead a dynamic Land Development team, fostering client relationships and driving project success. Enjoy autonomy in managing projects while mentoring staff and contributing to business growth in a col...

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$118K - $140K *

Elevate your career by leading solid waste engineering projects, managing teams, and driving growth. This dynamic role offers opportunities for professional development and potential firm ownership, a...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Technical Services

$115K - $158K *

Join a team that's driving innovation in project management for enterprise decisioning. Collaborate across business and technology teams to ensure successful delivery of complex initiatives while main...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $108K *

Unlock potential by managing diverse research projects, coordinating operations, and supporting data analysis. Collaborate with interdisciplinary teams to drive impactful educational initiatives and e...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Deliver leadership and governance for global clinical study management, ensuring projects meet timelines and budgets while fostering collaboration and operational excellence across teams and stakehold...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $266K *

Join a dynamic team to oversee global project and program delivery, ensuring alignment with strategic goals. Drive excellence in execution, manage complex initiatives, and foster collaboration across...

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Join a team that's dedicated to delivering innovative eDiscovery solutions. Collaborate with cross-functional teams to manage client relationships, oversee project execution, and provide expert guidan...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$100K *

Join a team that's managing environmental projects, ensuring quality and compliance while mentoring junior staff and driving business development efforts in the oil and gas sector...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$120K - $145K *

Join a team that's advancing oncology solutions by managing global clinical trials. Lead project execution from protocol development to study closeout, ensuring quality and compliance while fostering...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Pioneer innovative IRT solutions for clinical trials by leading project design, collaborating with stakeholders, and ensuring effective system delivery. Drive project milestones, manage technical spec...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Grow your career with impactful project management in power distribution, overseeing engineering designs and financials. Collaborate with clients and teams to drive success in a dynamic environment fo...

Reposted today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Lead the charge in managing dynamic Power Distribution projects, overseeing engineering designs, client communications, and business development to ensure timely, cost-effective delivery while enhanci...

Reposted today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Drive clinical data management excellence by leading strategies, ensuring data integrity, and collaborating across functions to support successful clinical trials and regulatory submissions in a dynam...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$247K - $345K *

Unlock potential by leading enterprise-wide strategic initiatives, optimizing program execution, and enhancing technology portfolio management. Drive cross-functional collaboration and operational eff...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Consumer Technology

$90K - $95K *

Innovate facility management by overseeing maintenance, safety, and operational standards. Lead a team to ensure efficient building systems, implement quality assurance, and manage budgets while foste...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$75K - $109K *

Advance the future of Building Information Modeling by leading BIM strategies, ensuring model quality, and mentoring teams. Drive innovation through technology initiatives and enhance project delivery...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$140K - $175K *

Lead large-scale land development projects, guiding teams to deliver high-quality designs across commercial, residential, and institutional sectors while ensuring successful execution and stakeholder...

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $125K *

Champion the development of healthcare marketing tools by guiding cross-functional teams through the product lifecycle, driving innovative features and optimizing user experiences to enhance HCP engag...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Elevate building performance by designing and analyzing enclosure systems. Lead projects, collaborate with teams, and ensure high-quality standards in construction and design. Utilize technical expert...

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Drive successful delivery of a complex SAP S/4HANA enhancement initiative by managing multiple workstreams, coordinating with stakeholders, and ensuring alignment with strategic priorities and project...

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$161K - $210K *

Elevate workforce management by leading recruitment, onboarding, and performance strategies. Drive clinician readiness and productivity while ensuring quality care through data-driven decision-making...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$122K - $212K *

Lead high-impact pharmacy innovation programs, shaping product vision and strategy while driving cross-functional collaboration to enhance patient experiences and operational efficiency...

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $160K *

Create impactful data solutions by leading a cross-functional team in managing high-priority IT projects for federal clients. Drive collaboration and ensure project success through effective communica...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Transform the onboarding experience for enterprise customers by leading seamless implementations, balancing technical demands with stakeholder communication, and driving effective project management t...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Drive project success by managing all phases from award to completion, overseeing teams, ensuring compliance, and maintaining financial integrity. Collaborate across departments to deliver high-qualit...

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.