Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$140K - $180K *

Lead a dynamic civil engineering team, driving innovative site and land development projects across the Midwest. Oversee project execution, mentor engineers, and ensure high-quality results while fost...

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$73K - $87K *

Unlock potential by driving transformation through emerging technologies. Collaborate with stakeholders to analyze, prototype, and implement AI solutions that address real-world challenges, ensuring h...

6 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$150K - $180K *

Lead and develop a high-performing team of enterprise account executives, driving revenue growth and shaping sales strategies in the finance sector. Engage with senior decision-makers and manage compl...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$280K - $330K *

Empower a dynamic engineering team by leading technical architecture, enhancing system reliability, and driving scalable solutions that support rapid growth in a fast-paced fintech environment. Foster...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$133K - $199K *

Lead the charge in optimizing supply chain strategies and managing diverse teams to achieve cost objectives. Drive procurement methodologies and foster supplier partnerships while ensuring alignment w...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$120K - $145K *

Champion innovative solutions by collaborating with clients to align IT capabilities with business goals. Leverage your expertise in enterprise architecture to drive strategic initiatives and optimize...

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$108K - $130K *

Champion innovative software solutions by leading a dynamic engineering team. Collaborate with cross-functional partners to enhance product delivery and drive continuous improvement in a creative, Agi...

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$150K - $160K *

Lead the charge in executing population health strategies, ensuring high-quality consulting delivery and team performance across regions. Collaborate with leadership to drive impactful solutions and f...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$108K - $162K *

Champion customer support by managing maintenance services and operations. Lead a team to ensure timely resolutions and enhance product performance while utilizing technical expertise and strategic pl...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Join us to lead talent acquisition and development initiatives, fostering a culture of growth and training. Collaborate with leaders to enhance staffing strategies and build programs that empower empl...

5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$192K - $229K *

Lead the charge in delivering comprehensive data migration services for SAP-enabled transformations, ensuring effective governance, client engagement, and execution of best practices across diverse da...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Drive operational excellence by leading a high-performing team in a dynamic fulfillment environment. Oversee daily operations, enhance client relationships, and ensure safety and productivity while fo...

Reposted yesterday

  •   5 - 7 years exp.  •   Transportation

$100K - $167K *

Transform client onboarding and conversion initiatives by leveraging your expertise in investment accounting. Collaborate with clients and cross-functional teams to ensure seamless integration and hig...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$75K - $105K *

Champion project success by collaborating with teams to develop technical strategies, manage client communications, and ensure profitable project execution across diverse industrial applications...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $175K *

Lead the charge in integrating acquisitions by developing operational capabilities, ensuring seamless transitions, and driving performance improvements across multiple functions to enhance customer re...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $251K *

Pioneer innovative technology strategies and architectural solutions across Agile teams, driving AI-enabled engineering transformation and ensuring scalable, secure, and maintainable solutions for ent...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$116K - $143K *

Drive the success of Material Movement Automation projects by leading cross-functional teams, managing timelines and budgets, and ensuring operational readiness while prioritizing safety and quality a...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$238K - $280K *

Shape the future of AI/LLM security by leading innovative offensive strategies, defining technical vision, and driving cross-company initiatives to enhance NodeZero's capabilities in identifying and e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$238K - $357K *

Transform growth strategies by leading AI initiatives, targeting key customers, and driving adoption through innovative partnerships and market insights. Collaborate across teams to enhance product of...

RemoteRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$232K - $348K *

Lead the charge in oncology pharmacology, managing scientific teams to drive drug discovery from early stages through regulatory approval while ensuring alignment across cross-functional teams...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$88K - $105K *

Drive operational excellence by owning the Professional Services intake and workflow governance processes, ensuring efficient request management and seamless team collaboration to enhance service deli...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Elevate brand visibility and engagement by managing PR agency partnerships, developing internal communications strategies, and ensuring consistent messaging across channels to strengthen organizationa...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Media

$150K - $250K *

Take ownership of comprehensive fraud risk management across consumer and small business segments. Lead detection frameworks, analyze fraud patterns, and collaborate cross-functionally to enhance prod...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $140K *

Join a team that leads innovative research and policy analysis to advance a clean, affordable, and resilient electricity future. Collaborate with policymakers and stakeholders, translating complex fin...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Energy & Utilities

$207K - $346K *

Lead the charge in evidence-based medical case reviews to ensure high-quality patient care while collaborating with a network of over 500 physician colleagues in a fully remote environment...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.