Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$110K - $181K *

Champion impactful technical product strategies, driving customer and business outcomes by collaborating with diverse stakeholders to prioritize solutions, enhance platform performance, and ensure sea...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$141K - $204K *

Drive strategic growth for DSD by leveraging data, analytics, and tools to enhance operational performance and achieve expansion goals. Collaborate with leadership to support initiatives that elevate...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $150K *

Empower growth by leading multidisciplinary teams in the planning, design, and execution of municipal water and wastewater projects, ensuring compliance and fostering client relationships to enhance m...

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $130K *

Join a team that's dedicated to delivering successful projects through effective management, collaboration, and strategic planning. You'll oversee project teams, budgets, and schedules while ensuring...

3 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$144K - $195K *

Innovate and lead the design of identity management solutions, ensuring security and integration across platforms. Collaborate with teams to enhance user experience and manage critical issues in a dyn...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $172K *

Unlock potential by leading the design and deployment of a global Quality Management System, ensuring compliance and operational excellence across multiple aerospace sites while fostering collaboratio...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$119K - $186K *

Champion a data-driven approach to learning effectiveness, enhancing measurement, evaluation, and reporting across diverse learning modalities. Collaborate with cross-functional teams to optimize lear...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$116K - $146K *

Drive impactful image programs and projects across multiple channels, ensuring compliance, safety, and customer satisfaction. Manage budgets of $25-$45 million while coordinating with stakeholders and...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$300K - $357K *

Join a team that's redefining business strategy in the Resources industry. Leverage your expertise to guide clients through complex challenges, driving impactful decisions at the C-suite level while m...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$223K - $293K *

Transform the future of R&D by leading digital product strategy and execution, enhancing study budget management and resource forecasting through innovative technology solutions and cross-functional c...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Pioneer operational excellence by driving staffing visibility and standardized planning across diverse content teams. Collaborate with stakeholders to enhance resource management and optimize project...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$125K - $187K *

Transform energy efficiency initiatives by leading a skilled engineering team. Drive project execution, mentor talent, and enhance program delivery across multiple states, ensuring impactful cost savi...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$201K - $251K *

Champion Quality governance by leading the development and management of Quality Agreements across global operations, ensuring compliance and effective partnerships with internal and external stakehol...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$115K - $130K *

Transform the contracting process by managing the lifecycle of agreements, ensuring efficient execution while balancing risk and compliance. Collaborate with cross-functional teams to support business...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $90K *

Join a team that's dedicated to strategic program execution and risk mitigation. As a key analyst, you'll prepare and evaluate initiatives, collaborate across functions, and drive project success thro...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Staffing

$150K - $180K *

Drive operational excellence by leading the S&OP strategy, aligning resources with business goals, and optimizing capacity planning across the network to enhance efficiency and service delivery...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$120K - $191K *

Transform the future of file management by leading a critical platform that ensures secure, reliable, and scalable file transfer and integration, while driving customer value and aligning with organiz...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $191K *

Lead the charge in defining and executing the vision for Enterprise File Services, ensuring secure and scalable file management solutions that align with organizational priorities and deliver measurab...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Lead transformative Workday implementations, managing client relationships and project lifecycles. Drive innovation and strategic growth while ensuring exceptional customer satisfaction and effective...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$170K - $200K *

Grow your career with a strategic leadership role driving sales growth, shaping market strategies, and leading cross-functional teams to enhance customer value and expand market share in a dynamic env...

RemoteRemote

3 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$140K - $187K *

Lead the charge in strategic and operational excellence for substation engineering, overseeing project execution, team development, and client relationships to drive growth and ensure high-quality del...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$160K - $200K *

Champion revenue growth by leading proposal operations and capture strategies. Drive compliance and execution across multiple concurrent pursuits while building scalable infrastructure to enhance mark...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Business Services

$145K - $163K *

Drive product strategy and roadmap for a complex portfolio, collaborating with cross-functional teams to enhance customer outcomes and market differentiation while balancing business objectives and te...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Information Technology

$125K - $150K *

Transform product strategy by leading impactful initiatives that enhance user experience and drive growth. Collaborate with cross-functional teams to deliver innovative solutions that delight customer...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$230K - $334K *

Join a team that's redefining software excellence by leading cross-platform engineering initiatives. Drive strategy, foster collaboration, and enhance customer experiences across desktop, mobile, and...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.