Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$139K - $232K *

Unlock potential by providing enterprise architecture leadership for Corporate Functions, focusing on Finance and supporting areas. Shape technology strategies and roadmaps to enhance financial manage...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$179K - $280K *

Shape the future of product marketing by leading a dynamic team focused on innovation, market resonance, and compelling narratives to drive product adoption and growth in a fast-paced environment...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $150K *

Accelerate your career by leading sales growth and strategic partnerships in the Executive Benefits sector. Drive revenue, expand market presence, and enhance employee protection through innovative id...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Advance customer engagement in banking by executing product strategies and managing CRM solutions. Collaborate with cross-functional teams to enhance customer relationships and drive measurable value...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$165K - $228K *

Engage with customers to shape the future of Hyperscale Data Center networks. Lead architecture discussions, drive technology roadmaps, and collaborate with teams to deliver scalable, high-performance...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Shape the future of healthcare technology by leading product strategy and execution. Collaborate with cross-functional teams to enhance platform capabilities, drive adoption, and deliver innovative so...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $180K *

Transform underwriting strategies by managing excess casualty business, fostering relationships with wholesale partners, and ensuring profitable outcomes while adhering to company guidelines and marke...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$115K - $140K *

Elevate employee engagement by developing impactful communication programs that connect teams to business priorities. Collaborate with leaders to translate complex information into clear, actionable m...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Technical Services

$146K - $229K *

Drive the AI roadmap and deliver secure, scalable solutions that enhance decision-making and streamline workflows. Lead teams from experimentation to production, ensuring measurable business value and...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$175K - $210K *

Transform the accounting landscape by leading a multi-disciplinary team, enhancing operational efficiency, and driving innovation through AI and automation while ensuring compliance and integrity in f...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$107K - $159K *

Join our global Total Rewards team to design and implement compensation programs that align with business objectives, ensuring compliance and competitive pay practices across international client grou...

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Support a dynamic team in sourcing and managing outsourced services, driving procurement strategies across multiple departments while ensuring compliance and fostering supplier relationships for optim...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $180K *

Drive growth by leading a team of Buyer Account Managers to enhance B2B sales performance, manage high-value buyer accounts, and implement AI-driven strategies for pipeline management and buyer engage...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$92K - $136K *

Help us drive customer success by owning and optimizing digital engagement programs. You'll lead strategy, build automated journeys, and analyze performance to enhance customer experiences and ensure...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Lead the charge in transforming data accessibility for product teams and AI agents. Oversee a team of data engineers to build a robust platform that ensures secure, reliable data usage across the orga...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$141K - $278K *

Advance operational excellence by leading MES initiatives, enhancing production efficiency, and driving digital transformation across manufacturing processes. Collaborate with teams to implement innov...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Business Services

$141K - $278K *

Join a team that's driving digital transformation in manufacturing. Lead MES initiatives to enhance operational excellence, streamline processes, and foster innovation across production and supply cha...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Business Services

$170K - $200K *

Transform your career by leading a high-performing sales team, driving strategic growth, and enhancing client relationships in a dynamic, global environment. Leverage your expertise in IoT solutions t...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Transportation

$229K - $258K *

Lead the charge in shaping product security strategy, driving cross-functional initiatives, and embedding security by design into engineering workflows. Collaborate with teams to enhance vulnerability...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $200K *

Join a team that's redefining partnerships in the automotive SaaS space. Lead strategic initiatives to enhance our developer ecosystem, drive commercial negotiations, and foster innovation across key...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Consumer Technology

$120K - $150K *

Drive growth by recruiting experienced financial advisors and teams. Collaborate with field leadership to develop strategies, manage pipelines, and enhance market presence, ensuring successful onboard...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$145K - $152K *

Champion program excellence by leading complex federal initiatives, managing multidisciplinary teams, and fostering strong stakeholder relationships to ensure successful delivery and client satisfacti...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$121K - $169K *

Shape the future of travel technology by leading complex technical projects. Collaborate across teams to define goals, manage risks, and ensure successful delivery while adapting practices to meet pro...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$144K - $242K *

Elevate your career by leading innovative media and advertising products. Drive audience targeting, measurement, and reporting strategies while collaborating with cross-functional teams to enhance adv...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$96K - $140K *

Join a team that's shaping the future of renewable energy through innovative land development and infrastructure projects. Lead design, permitting, and client management efforts while driving growth i...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.