Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$160K - $297K *

Empower your career by leading innovative marketing strategies that drive growth and enhance brand visibility. Collaborate with cross-functional teams to optimize campaigns and achieve revenue goals i...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$170K - $220K *

Shape the future of customer solutions by leading implementations and driving adoption of innovative technologies. Collaborate with teams to deliver tailored architectural designs that meet strategic...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$233K - $500K+*

Lead the development and execution of innovative global compensation strategies, partnering with stakeholders to enhance employee engagement while ensuring compliance and effectiveness in a dynamic ma...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Elevate the Managed Services team by leading specialists in review response, social media, and listings management. Drive operational excellence, client satisfaction, and revenue growth while ensuring...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$88K - $125K *

Unlock potential by leveraging advanced analytics and consultative skills to drive client success in the Consumer Healthcare vitamins sector. Collaborate cross-functionally to deliver insights and fos...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $104K *

Drive the full lifecycle of contractual agreements, ensuring compliance and efficiency while collaborating across teams to enhance processes and support organizational goals in a dynamic, remote-frien...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $100K *

Lead the charge in managing complex waste projects across the Midwest. Collaborate with diverse teams to ensure safe and efficient waste handling, transportation, and disposal while fostering strong c...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$262K - $394K *

Accelerate progress at Clio Phones by leading the growth of a cloud-native VoIP platform for law firms. Own P&L, build operational plans, and drive market strategy while managing cross-functional team...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$150K - $180K *

Drive strategic initiatives and operational excellence across a global portfolio, partnering with leadership to enhance business performance and deliver measurable outcomes in oncology and rare diseas...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$108K - $122K *

Champion exceptional corporate events by leading strategy, design, and execution of high-impact experiences for clients and executives, ensuring alignment with business goals and delivering premium se...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$97K - $145K *

Join a dynamic team to lead physician coding integration initiatives, ensuring operational readiness and compliance. Collaborate across departments to enhance coding practices and drive revenue cycle...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Execute accurate coding practices to ensure compliance and optimal reimbursement in a dynamic healthcare environment. Collaborate with clinical teams to maintain integrity and efficiency in revenue cy...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$155K - $170K *

Transform the national media landscape by leading strategic communications initiatives that elevate awareness of Alzheimer’s disease and dementia. Collaborate with executive leadership to drive impact...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Transform project delivery by leading multidisciplinary design coordination for complex industrial projects, ensuring seamless integration between clients, engineering teams, and external partners thr...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$120K - $145K *

Elevate data engineering by managing pipelines and operations, collaborating with stakeholders to define architecture, and driving project plans for optimal data solutions. Lead teams to ensure data q...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Unlock potential by managing and optimizing data and BI platforms. Collaborate with stakeholders to define architecture, drive project plans, and ensure data quality while leading a team to deliver im...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$160K - $185K *

Lead the charge in developing compelling proposals for government contracts, managing the entire proposal process from strategy to submission. Collaborate with cross-functional teams to ensure complia...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$115K - $185K *

Manage and enhance revenue cycle operations, driving accountability and excellence through data analysis and strategic oversight. Collaborate with leadership to optimize performance and implement best...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$115K - $185K *

Lead the charge in optimizing hospital accounts receivable operations, driving cash acceleration, reducing denials, and enhancing revenue realization through strategic partnerships and data-driven dec...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $90K *

Launch your design career by creating user-driven experiences and collaborating with cross-functional teams. Develop wireframes, prototypes, and polished UI while growing your skills in a dynamic envi...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$73K - $212K *

Lead innovative AI solutions as a Manager in Data and Analytics Engineering. Supervise teams, manage client accounts, and drive exceptional results while fostering relationships and embracing technolo...

3 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$147K - $215K *

Optimize customer partnerships by driving operational excellence, resolving site challenges, and enhancing system performance. Collaborate with cross-functional teams to ensure effective delivery of c...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$120K - $150K *

Lead impactful communications strategies that enhance reputation and visibility. Collaborate with senior leaders to navigate complex issues, ensuring alignment with organizational goals while managing...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Hospitality & Recreation

$163K - $322K *

Drive Finance Transformation initiatives by leading planning, forecasting, and performance management projects. Collaborate with teams to implement Anaplan solutions while managing deliverables and me...

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$163K - $322K *

Unlock potential by leading Finance Transformation initiatives, managing project deliverables, and collaborating with cross-functional teams to implement Anaplan solutions. Coach junior members and dr...

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.