Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$80K - $95K *

Unlock potential by managing financial accuracy and insights, overseeing month-end close, budgeting, and project accounting. Collaborate closely with the Controller to ensure compliance and streamline...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$91K - $121K *

Elevate the commercialization process across the product portfolio, enhancing efficiency and data integrity. Lead cross-functional collaboration, implement automation innovations, and drive strategic...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Deliver impactful project management by co-managing resources, schedules, and risks. Ensure compliance and alignment with strategic goals while utilizing reporting tools to track performance and drive...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$148K - $160K *

Partner with us to drive effective cost management for global construction projects. Leverage your expertise to support project managers, optimize budgets, and mitigate risks, ensuring successful proj...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$99K - $166K *

Join a dynamic team to manage supplier agreements, ensuring compliance and efficiency in contract administration. Drive governance processes, facilitate stakeholder collaboration, and enhance contract...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$85K - $100K *

Transform workplace safety and compliance by leading EHS initiatives, ensuring adherence to regulations, and fostering a culture of health and safety within the manufacturing environment...

3 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$161K - $269K *

Lead the development of innovative medical drug contracting solutions, collaborating with internal and external partners to enhance offerings for Health Plans and Employer Groups, while driving client...

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$235K - $270K *

Unlock potential by leading actuarial strategy and health economic analyses. Collaborate with cross-functional teams to enhance value propositions and drive commercial growth while translating complex...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Join a dynamic team to drive operational excellence through data-driven strategies. Lead workforce planning, enhance performance metrics, and collaborate across functions to optimize patient services...

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$87K - $108K *

Join a team that's shaping the future of water and energy utilities by leading proposal development, coordinating resources, and implementing winning strategies. Collaborate with experts to create imp...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $140K *

Engage with Private Equity firms to develop strategic partnerships, promoting supply chain services and driving revenue growth through effective channel management and collaboration with stakeholders...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$120K - $135K *

Transform the member experience by leading lifecycle marketing strategies that enhance engagement and retention across digital platforms. Drive campaign execution and optimize member journeys using da...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Lead comprehensive purchasing operations, influencing sourcing strategies and supplier partnerships to achieve production goals and drive continuous improvement in a dynamic environment...

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$141K - $278K *

Manage the design and implementation of ServiceNow HRSD solutions, collaborating with teams to enhance HR practices and drive transformation. Lead project workstreams, ensuring timely delivery and qua...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$141K - $278K *

Partner with us to lead the design and implementation of ServiceNow HRSD solutions, collaborating with teams to enhance HR practices and drive transformation, ensuring effective delivery and a superio...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Transform complex product concepts into intuitive user experiences across various platforms. Collaborate in a high-ownership role, focusing on enterprise design that meets diverse user needs while ens...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $460K *

Lead the charge in managing complex energy storage projects, driving innovative solutions in renewable energy. Collaborate with multi-disciplinary teams to ensure project success from development to e...

3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$140K - $460K *

Champion renewable energy by managing complex energy storage projects. You'll lead multidisciplinary teams, oversee project scope, schedules, and budgets while driving innovation and efficiency from c...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $123K *

Lead the charge in pharmaceutical meetings operations, driving client partnerships and operational excellence while navigating compliance. Shape processes and enhance stakeholder engagement to deliver...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Transportation

$125K - $150K *

Pioneer the national self-perform strategy, collaborating with regional leaders to enhance operations, training, and resource allocation while driving financial performance and project success across...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$80K - $95K *

Elevate project management effectiveness by providing advanced administrative support, ensuring adherence to policies, and enhancing team performance through training and reporting. Drive project succ...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$95K - $115K *

Champion client success by managing complex engagements in healthcare solutions. Leverage your expertise to enhance Quality/HEDIS, CMS Stars, and Risk Adjustment outcomes, ensuring effective adoption...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $230K *

Join a dynamic team as you lead engineering efforts to develop an AI Patient Engagement Agent, transforming clinical trials by automating patient interactions and enhancing operational efficiency for...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $230K *

Lead the charge in optimizing manufacturing processes through effective management of the Automation and Controls team, ensuring strategic alignment with innovation initiatives while fostering a cultu...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$275K - $350K *

Lead the charge in building a subscription research business, driving sales and market strategy across energy, trading, and institutional sectors. Collaborate with analysts to tailor offerings and est...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.