Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$100K - $120K *

Elevate product innovation in the insurance sector by collaborating with cross-functional teams to develop and launch new offerings, enhance existing products, and drive market growth while ensuring c...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Elevate project outcomes by overseeing technology integration and management, ensuring deliverables align with quality, budget, and safety standards while fostering collaboration and leadership across...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Advance your career by driving business development in clinical research and medical imaging. Build strategic client relationships, identify new opportunities, and contribute to innovative healthcare...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$161K - $202K *

Analyze business operations to drive strategic improvements in health coaching. Collaborate with cross-functional teams to enhance program outcomes, utilizing data-driven insights and effective commun...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$150K - $190K *

Join a dynamic team as you lead financial planning and analysis, driving strategic insights and operational excellence. Collaborate with executives to enhance decision-making and implement innovative...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$79K - $106K *

Oversee the technical backbone of the Development department's data ecosystem, managing CRM administration, data reporting, and business solutions analysis to enhance donor experience and operational...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$173K - $288K *

Empower growth and relationships in a strategic role focused on managing key accounts. Drive customer satisfaction and revenue retention through strategic collaboration and consultative selling within...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$121K - $176K *

Take ownership of environmental compliance leadership across major utility-scale power generation projects, ensuring adherence to regulations while collaborating with teams and regulatory agencies thr...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $140K *

Drive impactful projects by managing piping and process systems from concept to completion. Collaborate with teams to ensure project success while maintaining customer satisfaction and overseeing all...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$180K - $248K *

Shape the future of connected devices as the product leader for in-field asset monitoring. Own the hardware roadmap, drive product introductions, and ensure reliability, directly influencing a key gro...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$190K - $200K *

Manage strategic customer engagement and growth within Navy and DoD sectors. Leverage existing networks and industry insights to identify business opportunities that align with Millennium’s objectives...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Information Technology

$120K - $145K *

Shape the future of enterprise software by leading product strategy, design, and delivery for impactful applications supporting federal missions. Collaborate across multifunctional teams to ensure sec...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $180K *

Advance sales growth by leading a dynamic team, implementing strategic plans, and enhancing client relationships in a fast-paced environment. Drive performance through coaching and collaboration with...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$148K - $178K *

Transform municipal services by leading complex projects and optimizing the Accela Civic Platform. Drive innovation in permitting and development processes while ensuring compliance and enhancing cust...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Lead global accounting functions, ensuring integrity and efficiency in financial processes. Supervise teams across multiple locations while enhancing reporting accuracy and compliance within a growing...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $210K *

Elevate project outcomes by leading controls design for data center developments. Collaborate with clients and teams to ensure high-quality automation solutions, integrating advanced technologies and...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$142K - $213K *

Join us to lead the proposal lifecycle for federal opportunities, collaborating with cross-functional teams to create compelling submissions that enhance win probability and support mission-driven out...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$160K - $170K *

Elevate your career by partnering with divisional leadership to drive financial strategy, enhance operational efficiency, and ensure accurate financial reporting within a dynamic SaaS environment. Mak...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$131K - $204K *

Shape the future of project management by leading a dynamic team to oversee cost, schedule, and risk across major projects. Drive compliance and enhance project health through strategic planning and e...

2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$121K - $170K *

Advance your career by leading physical security solutions, driving operational excellence, and fostering team development. Collaborate across functions to enhance client outcomes and achieve strategi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$166K - $193K *

Lead and mentor a team of engineers while overseeing technical excellence and driving AI innovation in operational systems. Collaborate cross-functionally to deliver impactful features for post-purcha...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Information Technology

$75K - $100K *

Join a dynamic team to drive project success from concept to completion. Collaborate with customers and internal teams to deliver tailored solutions, manage costs, and enhance processes in a fast-pace...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$173K - $290K *

Champion innovation in product development platforms, driving strategy and execution for AI-first tools that enhance collaboration and efficiency across teams. Lead the evolution of platforms, ensurin...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead complex integration initiatives that drive strategic change and enhance business capabilities. Collaborate with senior leaders and cross-functional teams to ensure timely delivery of projects, ma...

Reposted yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$98K - $122K *

Unlock potential by leading the design and implementation of innovative warehouse solutions. Collaborate with cross-functional teams to optimize operations, ensuring compliance with safety and quality...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Transportation

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.