Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$80K - $120K *

Accelerate progress at our company by driving new customer acquisition and revenue growth in warehousing and logistics. Leverage your expertise to build relationships and secure opportunities in the K...

2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$135K - $160K *

Shape the future of digital experiences for financial advisors, leading a team to enhance practice growth through AI-driven insights and strategic initiatives. Drive cross-functional collaboration and...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in clinical study start-up operations, driving team development and ensuring timely site activation. Collaborate cross-functionally to enhance processes, meet regulatory standards, and...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$144K - $180K *

Join a team that's redefining healthcare affordability by leading strategic initiatives to enhance cost management and improve quality outcomes across the organization. Collaborate with diverse teams...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Advance the procurement team by leading subcontract negotiations, ensuring compliance, and fostering supplier relationships to deliver quality materials for engineering development programs...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$162K - $185K *

Drive strategic product development to meet growth goals, prioritizing user impact and results while collaborating with cross-functional teams to deliver innovative solutions that resonate with both B...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$125K - $150K *

Empower strategic financial decisions by analyzing investments, market opportunities, and capital allocation. Collaborate with C-suite executives to drive growth and optimize resource allocation while...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Transportation

$115K - $145K *

Drive AI transformation by managing strategic technology initiatives, ensuring clear communication and governance across teams. Your role is pivotal in navigating complexities and aligning priorities...

4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$160K - $200K *

Drive profitable growth and maximize performance in medical product categories. Lead cross-functional teams to execute strategies, enhance customer focus, and achieve financial goals while fostering i...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Shape the future of client program management by leading strategic initiatives, enhancing team performance, and driving impactful growth across global accounts while fostering collaboration and innova...

Yesterday

  •   11 - 15 years exp.  •   Business Services

$120K - $145K *

Accelerate progress at the forefront of client program management, leading a dynamic team to enhance global consulting services through strategic execution, stakeholder collaboration, and innovative d...

Yesterday

  •   11 - 15 years exp.  •   Business Services

$100K - $120K *

Manage complex digital investigations and data preservation efforts, leading a team in the collection and analysis of electronically stored information (ESI) while ensuring compliance with legal proto...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$66K - $132K *

Oversee technology projects that enhance healthcare delivery, collaborating with diverse teams to ensure successful implementation and operational support while managing risks and stakeholder communic...

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $166K *

Elevate your career by managing clinical trial data processes from start to finish. Collaborate with teams to ensure quality and compliance while overseeing database development and testing for impact...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$94K - $118K *

Transform knowledge management by leading a team to enhance content delivery, improve operational efficiency, and leverage AI solutions. Collaborate across functions to create accessible information t...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Join a team that's redefining enterprise data management by leading cross-functional initiatives, ensuring data reliability, and driving strategic insights through advanced program management and tech...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$131K - $178K *

Transform enterprise identity governance by leading IGA projects, ensuring timely delivery and alignment with mission needs. Collaborate across teams to enhance security and compliance in a dynamic IC...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Manage quality initiatives across renewable energy projects, ensuring compliance with standards and fostering collaboration among stakeholders. Drive continuous improvement and lead quality training t...

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$120K - $145K *

Accelerate progress at a leading tech firm by driving go-to-market planning and operational execution. Lead strategic initiatives, manage forecasting, and enhance cross-functional alignment to support...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $210K *

Unlock potential by leading HEOR strategy and AI integration, ensuring project success and client satisfaction. Drive business growth, mentor teams, and influence health policy through innovative rese...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$170K - $205K *

Drive the integration and growth of a newly acquired business, overseeing P&L, client relationships, and operations. Collaborate with teams to ensure seamless transition and performance against revenu...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Real Estate & Construction

$138K - $200K *

Drive the strategic direction of enterprise security infrastructure, leading teams to design, implement, and optimize security solutions across on-premises, cloud, and hybrid environments while ensuri...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$122K - $207K *

Join a team that's dedicated to optimizing operations in a fast-paced environment. Oversee daily functions, lead staff development, and ensure network reliability while managing resources effectively...

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$134K - $249K *

Lead the charge in developing and executing strategic business initiatives that integrate product offerings and adaptive technologies, ensuring seamless collaboration across functions to enhance clien...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$268K - $402K *

Champion the epilepsy pipeline by leading global medical strategies, ensuring regional insights drive clinical development and evidence generation. Collaborate across teams to address healthcare needs...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.