Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Director of Business Development - Warehousing, Distribution & 3PL Sales
$80K - $120K *
Accelerate progress at our company by driving new customer acquisition and revenue growth in warehousing and logistics. Leverage your expertise to build relationships and secure opportunities in the K...
2 weeks ago
Director - Digital Experience & Strategy (Practice Desktop)
$135K - $160K *
Shape the future of digital experiences for financial advisors, leading a team to enhance practice growth through AI-driven insights and strategic initiatives. Drive cross-functional collaboration and...
5 days ago
Associate Director, Study Start-Up
$110K - $130K *
Lead the charge in clinical study start-up operations, driving team development and ensuring timely site activation. Collaborate cross-functionally to enhance processes, meet regulatory standards, and...
4 weeks ago
Vice President, Cost Management - Affordability
$144K - $180K *
Join a team that's redefining healthcare affordability by leading strategic initiatives to enhance cost management and improve quality outcomes across the organization. Collaborate with diverse teams...
4 days ago
$95K - $115K *
Advance the procurement team by leading subcontract negotiations, ensuring compliance, and fostering supplier relationships to deliver quality materials for engineering development programs...
Reposted 1 week ago
$162K - $185K *
Drive strategic product development to meet growth goals, prioritizing user impact and results while collaborating with cross-functional teams to deliver innovative solutions that resonate with both B...
Reposted 1 week ago
$125K - $150K *
Empower strategic financial decisions by analyzing investments, market opportunities, and capital allocation. Collaborate with C-suite executives to drive growth and optimize resource allocation while...
3 weeks ago
$115K - $145K *
Drive AI transformation by managing strategic technology initiatives, ensuring clear communication and governance across teams. Your role is pivotal in navigating complexities and aligning priorities...
4 weeks ago
$160K - $200K *
Drive profitable growth and maximize performance in medical product categories. Lead cross-functional teams to execute strategies, enhance customer focus, and achieve financial goals while fostering i...
Yesterday
Senior Manager, Client Excellence, Global Consulting Services
$125K - $150K *
Shape the future of client program management by leading strategic initiatives, enhancing team performance, and driving impactful growth across global accounts while fostering collaboration and innova...
Yesterday
Senior Manager, Client Excellence, Global Consulting Services
$120K - $145K *
Accelerate progress at the forefront of client program management, leading a dynamic team to enhance global consulting services through strategic execution, stakeholder collaboration, and innovative d...
Yesterday
Manager, Digital Forensics & Expert Services
$100K - $120K *
Manage complex digital investigations and data preservation efforts, leading a team in the collection and analysis of electronically stored information (ESI) while ensuring compliance with legal proto...
3 days ago
$66K - $132K *
Oversee technology projects that enhance healthcare delivery, collaborating with diverse teams to ensure successful implementation and operational support while managing risks and stakeholder communic...
5 days ago
$100K - $166K *
Elevate your career by managing clinical trial data processes from start to finish. Collaborate with teams to ensure quality and compliance while overseeing database development and testing for impact...
3 days ago
$94K - $118K *
Transform knowledge management by leading a team to enhance content delivery, improve operational efficiency, and leverage AI solutions. Collaborate across functions to create accessible information t...
4 days ago
Sr Technical Program Manager, Data
$120K - $145K *
Join a team that's redefining enterprise data management by leading cross-functional initiatives, ensuring data reliability, and driving strategic insights through advanced program management and tech...
3 days ago
ICAM Project Manager – Identity Governance & Administration (IGA)
$131K - $178K *
Transform enterprise identity governance by leading IGA projects, ensuring timely delivery and alignment with mission needs. Collaborate across teams to enhance security and compliance in a dynamic IC...
1 week ago
Project Quality Manager (Traveler)
$80K - $95K *
Manage quality initiatives across renewable energy projects, ensuring compliance with standards and fostering collaboration among stakeholders. Drive continuous improvement and lead quality training t...
1 week ago
Senior Manager, GTM Business Planning
$120K - $145K *
Accelerate progress at a leading tech firm by driving go-to-market planning and operational execution. Lead strategic initiatives, manage forecasting, and enhance cross-functional alignment to support...
5 days ago
Executive Director, HEOR Modeling
$175K - $210K *
Unlock potential by leading HEOR strategy and AI integration, ensuring project success and client satisfaction. Drive business growth, mentor teams, and influence health policy through innovative rese...
1 week ago
General Manager, Project Dynamics
$170K - $205K *
Drive the integration and growth of a newly acquired business, overseeing P&L, client relationships, and operations. Collaborate with teams to ensure seamless transition and performance against revenu...
Reposted today
Director Security Infrastructure & Engineering
$138K - $200K *
Drive the strategic direction of enterprise security infrastructure, leading teams to design, implement, and optimize security solutions across on-premises, cloud, and hybrid environments while ensuri...
1 week ago
Manager, Operations Command Center
$122K - $207K *
Join a team that's dedicated to optimizing operations in a fast-paced environment. Oversee daily functions, lead staff development, and ensure network reliability while managing resources effectively...
2 weeks ago
Senior Director, Strategic Initiatives
$134K - $249K *
Lead the charge in developing and executing strategic business initiatives that integrate product offerings and adaptive technologies, ensuring seamless collaboration across functions to enhance clien...
Yesterday
Global Medical Director, Epilepsy Pipeline
$268K - $402K *
Champion the epilepsy pipeline by leading global medical strategies, ensuring regional insights drive clinical development and evidence generation. Collaborate across teams to address healthcare needs...
2 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.