Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$130K - $155K *

Lead the charge in developing Fleetio's connected-vehicle data strategy and product line from the ground up. Drive innovative data solutions, partnerships, and user experiences that enhance fleet oper...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$211K - $272K *

Transform your career by leading enterprise applications strategy and delivery. Collaborate with cross-functional teams to enhance processes, drive AI adoption, and ensure robust application architect...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$71K - $113K *

Contribute to project success by managing cost and schedule for plant outages. Collaborate with project teams to analyze budgets, track progress, and ensure timely reporting, all while adhering to pro...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$100K - $120K *

Manage and oversee retail banking construction programs, ensuring alignment with project goals. Collaborate with stakeholders, implement project management processes, and ensure compliance with qualit...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$120K - $145K *

Champion impactful programs by leading cross-functional teams, driving strategic alignment, and ensuring seamless execution. Leverage your expertise to manage complex initiatives that delight customer...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Lead and innovate sales strategies to drive revenue growth in the Gov/Ed sector. Collaborate with teams to enhance market share, develop strong partnerships, and ensure alignment across sales processe...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Inspire growth by driving enterprise partnerships in healthcare. Leverage your sales expertise to lead complex cycles, build relationships with C-suite stakeholders, and shape strategic initiatives in...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Champion project success by leading Microsoft D365 implementations and website development. Collaborate with cross-functional teams to ensure compliance and deliver high-quality results while managing...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$275K - $325K *

Drive the venture and private equity business by owning strategy, partnerships, and P&L. Collaborate with teams to establish Flex as the primary financial institution in the sector, leveraging your ex...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Optimize enterprise-wide manufacturing through Lean strategies and advanced engineering solutions. Lead initiatives to enhance safety, quality, and productivity while fostering a culture of operationa...

Reposted today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Join a team that's driving operational excellence and advanced engineering across multiple sites. Lead initiatives in Lean, automation, and process improvement to enhance productivity, safety, and qua...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$75K - $100K *

Champion the creative process by managing digital ad production, enhancing workflows, and collaborating with cross-functional teams to deliver high-quality marketing assets on time. Drive innovation a...

RemoteRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$160K - $180K *

Join us as a strategic operator to drive high-priority growth initiatives, aligning cross-functional teams and transforming ideas into actionable plans while leveraging AI tools for enhanced efficienc...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$100K - $200K *

Join a team that's driving business development across consulting, tax, and advisory services. Engage clients, build relationships, and manage the sales cycle to deliver tailored solutions and exceed...

3 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$95K - $115K *

Join a dynamic team to manage complex projects, ensuring timely delivery and quality. Utilize your analytical skills to develop reports and cost estimates while coordinating with government representa...

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Join a team that shapes global regulatory strategy in a fast-paced environment. You will lead comprehensive regulatory plans, ensuring alignment and execution from development to post-marketing, impac...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$252K - $300K *

Unlock potential by leading the technical strategy for Data Labs, guiding engineering teams to innovate AI training solutions, and shaping the future of model evaluation and deployment in a rapidly ev...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock potential by leading cross-functional initiatives to enhance caregiver enrollment technology. Drive strategy, optimize user experiences, and leverage data analytics to achieve growth in a dynam...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Pioneer innovative finance systems to enhance automation and reporting. Lead the integration of AI and controls in a fast-growing mental health company, collaborating across teams to ensure scalable f...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Transform the corporate internal audit landscape by shaping product strategy and developing AI-driven solutions that enhance efficiency and quality throughout the audit lifecycle, while collaborating...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$211K - $373K *

Innovate the consumer experience by leading product strategy and execution. Drive a high-performing team to enhance onboarding and insurance purchasing while aligning with cross-functional partners to...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$200K - $450K *

Drive independent credit review and risk management for all counterparties, ensuring compliance and security across diverse financial entities. Collaborate with cross-functional teams to uphold rigoro...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$269K - $370K *

Join a team that's transforming AI into a measurable business capability. Lead strategic initiatives, optimize operations, and collaborate across functions to enhance AI adoption and efficiency while...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$85K - $105K *

Analyze purchasing processes and vendor relationships to enhance operational efficiency. This role offers hands-on execution with potential for leadership, focusing on project ownership and strategic...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$185K - $315K *

Join us to shape strategic financial planning and analysis, leveraging AI to enhance forecasting and decision-making. This high-impact role collaborates with executives, driving insights that align wi...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.