Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$150K - $180K *

Lead the charge in engineering excellence, overseeing a team of 60 while driving AI initiatives and enhancing operational strategies. Collaborate with product leadership to elevate engineering practic...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$100K - $110K *

Drive critical cross-functional initiatives, bridging strategy and execution to enhance mobile and fixed video services. Lead project management, streamline operations, and deliver impactful reporting...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$150K - $180K *

Empower your career by leading security engineering initiatives across product, cloud, and AI domains. Drive security architecture, vulnerability management, and team growth while ensuring robust secu...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$148K - $274K *

Partner with us to navigate complex regulatory environments, ensuring compliance and facilitating business expansions. Leverage your expertise to advise leadership and manage licensure processes effec...

Missouri, USRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$92K - $126K *

Drive customer success by managing transformative enterprise projects, ensuring alignment and satisfaction. Collaborate with cross-functional teams to deliver exceptional results while mentoring other...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$101K - $152K *

Champion innovative solutions by leveraging Epic expertise to enhance operational efficiency and drive strategic initiatives across healthcare environments, ensuring high-performance standards and cli...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$100K - $130K *

Champion global expansion initiatives by managing the FedRAMP program. Collaborate with cross-functional teams to ensure project timelines and deliverables are met while navigating a fast-paced enviro...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$135K *

Unlock potential by leading the strategy and execution of hardware and support services for veterinary practices, driving P&L performance, vendor relationships, and cross-functional collaboration to e...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $190K *

Lead the charge in shaping data platform strategies and governance, driving innovative solutions and team development. Collaborate with partners to enhance AI readiness and ensure successful technical...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$170K - $230K *

Drive strategic growth and innovation in AI-enabled assessment and workforce solutions. Lead high-impact projects, foster collaboration, and enhance AIR's national leadership in education and workforc...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Join a team that's dedicated to enhancing third-party risk management. Oversee compliance assessments, drive risk mitigation strategies, and collaborate with cross-functional teams to ensure adherence...

Missouri, USRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Shape the future of project management by leading software implementations, fostering stakeholder relationships, and delivering quality results in complex environments. Collaborate with clients to ens...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$130K - $160K *

Lead the charge in project quality management, ensuring compliance with ISO standards and fostering a culture of safety and excellence. Collaborate with diverse teams to drive continuous improvement a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$88K - $105K *

Contribute to the successful execution of design-build projects in Life Sciences, overseeing all phases from design to closeout while mentoring junior staff and ensuring quality and timely delivery...

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$135K - $155K *

Drive impactful data solutions by bridging business needs with engineering teams. Own project intake, prioritize requests, and ensure clear communication across departments to enhance efficiency and d...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Transform technology strategy for Rewards and Fulfillment platforms while mentoring a high-performing team. Drive secure, scalable solutions and AI adoption in partnership with leadership and stakehol...

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Media

$110K - $130K *

Drive impactful AI and Agentforce delivery projects, managing customer relationships and internal initiatives. Leverage your strategic planning and analytical skills to oversee project execution and f...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$136K - $160K *

Drive global procurement strategies and foster client relationships while overseeing multi-regional teams. Lead sourcing initiatives, ensure compliance, and deliver measurable value aligned with clien...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$135K - $160K *

Lead the charge in scaling our Customer Success Management team, driving product adoption and retention across diverse customer segments. Collaborate cross-functionally to create impactful processes a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$135K - $160K *

Transform your career by leading global product development initiatives, enhancing quality and compliance while driving innovation and operational efficiency across cross-functional teams...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$75K - $87K *

Drive impactful events by managing logistics, budgets, and stakeholder engagement for both in-person and online conferences. Utilize your project management skills to enhance member experiences and en...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$150K *

Shape the future of client success by leveraging insights and data to enhance program impact. Collaborate with leaders in law firms and professional services to drive engagement and talent development...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$138K - $165K *

Elevate our product management efforts by driving innovation in cybersecurity. Collaborate with cross-functional teams to deliver impactful data-driven analytics, leveraging user insights and industry...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $220K *

Lead the charge in driving growth for our Guidewire InsuranceNow practice by developing strategic relationships, generating new business opportunities, and executing revenue strategies across the US i...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$130K - $155K *

Lead the charge in developing Fleetio's connected-vehicle data strategy and product line from the ground up. Drive innovative data solutions, partnerships, and user experiences that enhance fleet oper...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.