Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$90K - $140K *

Join a dynamic team to lead complex data management projects, blending Agile methodologies with technical expertise. Drive collaboration across healthcare analytics, ensuring successful delivery and s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$100K - $120K *

Drive product strategy by leveraging CMC expertise to translate customer needs into actionable requirements, collaborating with cross-functional teams to deliver user-focused solutions in an agile env...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive impactful medical communications projects from start to finish, ensuring timely execution and client satisfaction. Collaborate with multidisciplinary teams, manage budgets, and foster strong rel...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $95K *

Advance your career by managing diverse medical communications projects, ensuring timely delivery and client satisfaction while leading multidisciplinary teams and maintaining strong relationships wit...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Aerospace & Defense

$112K - $126K *

Join a team that's driving impactful healthcare solutions by managing complex projects from initiation to stabilization. Collaborate with cross-functional teams to ensure timely delivery and high-qual...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Drive project success by managing complex engineering assignments, ensuring quality delivery while fostering client relationships and supporting business development efforts across multiple teams and...

3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Empower your career by leading complex engineering projects, driving innovation, and building strong client relationships. Utilize your expertise to mentor teams and enhance organizational capabilitie...

3 weeks ago

  •   11 - 15 years exp.  •   Technical Services

$105K - $120K *

Join a team that's driving successful ERP and CRM software implementations. Lead projects, coordinate teams, and ensure timely delivery while achieving sales and profit targets. Collaborate with stake...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Media

$100K - $110K *

Unlock potential by leading complex projects within a dynamic ePMO, driving cross-functional alignment, and ensuring timely execution while communicating effectively with senior leadership to foster t...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$93K - $106K *

Lead impactful initiatives in equitable electric mobility, managing multi-state programs and fostering collaboration among diverse stakeholders to drive sustainable transportation policies and practic...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$125K - $135K *

Drive project success by managing complex global clinical trials, ensuring timely delivery and compliance with regulatory standards. Collaborate across teams and time zones to foster relationships and...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$105K - $115K *

Transform the future of building management by leading cross-regional teams to enhance EBMS delivery. Engage with stakeholders, manage multiple workstreams, and ensure timely project execution while d...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Real Estate & Construction

$93K - $166K *

Transform the future by leading complex projects that drive innovation and efficiency. Collaborate with cross-functional teams to deliver business value while managing scope, schedule, and resources i...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$172K - $203K *

Empower the distribution strategy by designing and managing rate content across channels, ensuring accurate delivery and partner trust. Collaborate with cross-functional teams to build scalable progra...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Explore a leadership role for large-scale projects, driving success through effective planning, risk management, and client relations while ensuring safety and financial performance throughout the pro...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$200K - $250K *

Transform your career by leading cross-functional R&D initiatives that enhance platform security and modernization. Drive impactful engineering decisions while mentoring a team of Staff Engineers to a...

RemoteRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$130K - $241K *

Join a team that's redefining product management by driving AI-first digital solutions. Collaborate with diverse experts to transform strategic goals into impactful customer experiences, ensuring succ...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$130K - $241K *

Unlock potential by leading innovative digital product strategies that enhance customer experiences. Collaborate with diverse teams to drive AI-first solutions, ensuring successful execution from idea...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Drive complex project implementations by leading cross-functional teams, managing deliverables, and ensuring compliance. Leverage Salesforce expertise to optimize processes and foster client relations...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $150K *

Join a team that's shaping the future of consulting in P&C insurance. Lead client engagements, ensure quality standards, and foster long-term relationships while driving business growth and mentoring...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$85K - $110K *

Inspire change by leading complex remediation projects, managing budgets, and collaborating with clients and regulators to achieve successful project outcomes while mentoring junior staff and ensuring...

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$95K - $115K *

Join a team that's dedicated to delivering innovative design-build projects, managing all phases from conception to closeout, and ensuring successful execution of multimillion-dollar initiatives acros...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Partner with us to lead complex design-build projects, managing all phases from conception to closeout. Collaborate with teams to ensure safety, quality, and efficiency on projects ranging from $20 mi...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Optimize project delivery by leading enterprise SaaS implementations for utility clients. Build strong client relationships, manage competing priorities, and ensure successful project outcomes across...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$110K - $130K *

Lead the charge in managing complex technical projects across IT, Security, and Compliance. Engage with customers to translate technical needs into actionable plans while ensuring seamless internal co...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.