Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$88K - $105K *

Unlock potential by leading complex programs, fostering collaboration across teams, and enhancing profitability while ensuring customer satisfaction. Grow your career with proven experience in program...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$107K - $199K *

Elevate operational excellence by leading Enterprise Business Operations, ensuring compliance and continuous improvement while fostering collaboration across stakeholders to drive strategic initiative...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$137K - $210K *

Lead the profitability and risk strategy for a diverse Asset Protection portfolio. Shape underwriting governance and drive data-informed decisions to enhance product performance across multiple market...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Bring your expertise to drive continuous improvement in manufacturing operations. Collaborate with cross-functional teams to manage projects, enhance processes, and lead digital transformations in a f...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $140K *

Drive product innovation by leading the development of AI-enabled solutions for public sector agencies, enhancing early childhood systems through strategic vision, technical architecture, and customer...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$114K - $143K *

Drive operational excellence as a Program Manager, enhancing EPD processes and collaboration. Leverage data insights to identify trends, improve efficiency, and support cross-functional teams in a dyn...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $127K *

Contribute to product strategy and lifecycle management, ensuring alignment with customer needs and market trends. Collaborate with cross-functional teams to drive product development and sustainment...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$110K - $130K *

Unlock your potential as a Program Manager, leading acoustical design and noise control strategies across diverse projects. Collaborate with cross-functional teams to ensure compliance, enhance perfor...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$170K - $222K *

Drive strategic transformation initiatives across Product, GTM, and Operations. Lead cross-functional teams, manage complex portfolios, and deliver measurable results while fostering clarity and accou...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$131K - $178K *

Join a team that's driving identity data management initiatives, ensuring accurate aggregation and synchronization of identity and entitlement data across diverse environments. Lead project delivery a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $160K *

Drive your career with a strategic role in Product Operations, partnering with leaders to transform complex challenges into actionable insights, while enhancing cross-functional collaboration and leve...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Drive execution of complex technical initiatives, translating business vision into actionable programs. Collaborate with cross-functional teams to ensure alignment with company objectives and measurab...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Transform the future of power delivery by managing complex transmission line projects. Lead teams, ensure quality, and drive project success while collaborating with engineers and stakeholders across...

4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$109K - $183K *

Lead a globally distributed team to enhance our SaaS platform by mentoring engineers, driving technical strategy, and building scalable solutions using .NET and React. Balance engineering and manageme...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$109K - $183K *

Empower your engineering expertise to lead a global team in enhancing our SaaS platform. Drive technical strategy, mentor engineers, and build scalable solutions using .NET and React while advancing A...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$190K - $210K *

Advance our real estate strategy by leading portfolio planning, workplace design, and data analysis. Collaborate with internal teams and external partners to optimize office spaces, enhance employee e...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Lead strategic product initiatives in advanced surgical technologies, driving development and commercialization efforts. Collaborate with cross-functional teams to enhance orthopedic outcomes and proc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$112K - $179K *

Lead the charge in managing complex IT projects from concept to implementation, ensuring timely delivery and compliance with federal standards. Collaborate with stakeholders to drive project success i...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$127K - $168K *

Drive impactful program management by overseeing service contracts, enhancing client relationships, and ensuring successful deployment of smart grid solutions. Collaborate with teams to meet performan...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$225K - $275K *

Join a global team to lead engineering responses for critical customer issues, ensuring swift resolutions and proactive risk management across endpoint, data security, email, and network products whil...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Consumer Technology

$100K - $130K *

Elevate business development strategies by partnering with practice groups to drive growth initiatives, enhance client relationships, and innovate marketing efforts within a dynamic legal environment...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Unlock potential by driving critical accounting and finance projects for diverse clients. Leverage your expertise to tackle complex challenges and enhance operational efficiency in a dynamic, collabor...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Business Services

$114K - $151K *

Unlock potential by leading the HV overhead switchgear portfolio, driving product strategy, market development, and cross-functional collaboration to achieve profitable growth and enhance utility solu...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$181K - $200K *

Champion transformative call center operations by leading strategic outreach, workforce management, and capacity planning. Drive efficiency and quality through innovative automation and AI solutions w...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Transform healthcare data management by leading the Encounter Data Submission strategy. Drive compliance, enhance processes, and collaborate across teams to ensure accurate, meaningful data submission...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.