Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$150K - $180K *

Pioneer innovative solutions as a Senior Manager in Deployed Engineering, leading hands-on deployments and building a high-performing team. Collaborate closely with customers and internal teams to dri...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the charge in expanding into new healthcare verticals by developing and executing go-to-market strategies, managing partnerships, and driving campaign performance. Collaborate with cross-function...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $207K *

Elevate business growth by driving new client acquisitions and expanding existing accounts, while monitoring customer satisfaction and providing operational guidance across multiple plants to ensure s...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$80K - $125K *

Unlock potential by guiding clients through Salesforce implementations, enhancing communication, managing change impacts, and delivering effective training to end-users, ensuring a smooth transition a...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$82K - $153K *

Unlock potential by driving acquisition strategies and building relationships with agency owners. Collaborate with leadership to enhance deal pipelines and support growth initiatives through effective...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$125K - $295K *

Drive global delivery success by managing hub economics, resourcing, and operational systems. Collaborate with finance and commercial teams to ensure consistent pricing and routing, while overseeing d...

3 weeks ago

  •   Less than 5 years exp.  •   Media

$170K - $200K *

Shape the future of healthcare integrations by leading product strategy and execution for seamless data connectivity between customer systems and our platform, enhancing user experience and operationa...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$121K - $164K *

Champion a team of analysts to enhance enterprise infrastructure services, ensuring reliable support and operational excellence. Collaborate with cross-functional teams to align priorities and drive c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Advance your career by leading digital delivery and innovation in Energy Advisory. Collaborate across teams to connect business needs with digital solutions, ensuring scalable and sustainable project...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$142K - $197K *

Drive strategic improvements and operational efficiency in Partnerships by establishing frameworks, integrating AI solutions, and optimizing team performance, all while collaborating with cross-functi...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Lead the proposal lifecycle by collaborating with cross-functional teams to create compelling, compliant proposals that drive growth in government contracting. Utilize your expertise to enhance proces...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Reimagine space management and GIS solutions, driving innovation in product strategy and execution. Collaborate with universities to enhance workflows, optimize features, and deliver impactful results...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $155K *

Join a dynamic team as a project manager focused on structural engineering, overseeing diverse building projects from expansions to renovations. Mentor junior staff while ensuring quality and accuracy...

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$122K - $261K *

Elevate employee experiences by leading digital transformation initiatives, providing strategic guidance, and implementing scalable solutions across enterprise environments to enhance productivity and...

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$120K - $145K *

Shape the future of data protection by leading a high-performing team of analysts. Drive incident response, enhance security strategies, and collaborate with clients to mitigate risks in a fast-paced...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$94K - $168K *

Drive strategic resource management by aligning talent with project needs, optimizing workforce planning, and enhancing operational efficiency across key business units to support organizational succe...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$120K - $170K *

Lead engineering efforts by writing production code and mentoring a team. Drive modernization initiatives through Java microservices while managing performance and growth of engineers. Collaborate wit...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$154K - $260K *

Champion cutting-edge AI solutions by leading a team to deploy real-time edge models, enhancing safety across millions of devices. Drive technical strategy and foster collaboration to deliver impactfu...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $145K *

Drive product strategy and modernization for merchant onboarding solutions, collaborating with cross-functional teams to enhance risk management capabilities and ensure market-leading standards in a d...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Lead high-impact, cross-functional technical programs, translating business vision into structured execution. Drive Agile practices, enhance team efficiency, and ensure alignment with company objectiv...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $180K *

Elevate your career by driving business growth in the biotech and pharma sectors. This role allows you to influence strategies, build partnerships, and deliver sustainable revenue through innovative p...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $219K *

Drive the vision for Samsara device installations, enhancing user experiences and ensuring rapid, accurate setups. Collaborate with cross-functional teams to optimize the install process, making impac...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$240K - $330K *

Champion the development of onboard software for autonomous vehicles, leading cross-functional teams to ensure a robust software foundation. Drive strategic vision, quality, and operational excellence...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Transportation

$125K - $190K *

Accelerate progress at a leading Customer Success team, driving renewal outcomes and enhancing team effectiveness through innovative engagement strategies and AI-driven solutions for a diverse portfol...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$133K - $166K *

Champion the fundraising efforts of a dynamic corporate finance team, managing complex debt and equity processes while collaborating with senior leadership to craft compelling narratives for investors...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.