Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$201K - $251K *

Lead strategic forecasting initiatives to drive decision-making in oncology. Collaborate with cross-functional teams to develop long-term models and communicate insights that shape product and portfol...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the execution of complex client programs, ensuring timely delivery and budget adherence. Collaborate with cross-functional teams to drive accountability and clarity, while proactively managing ri...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$108K - $147K *

Transform application development by leading a dynamic team to deliver innovative solutions, manage project priorities, and enhance collaboration across technical and business stakeholders in a fast-p...

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Lead the charge in transforming marketing operations through innovative MarTech solutions, driving student and partner success while optimizing efficiency across a multi-brand ecosystem. Own product s...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$185K - $256K *

Join a team that's redefining CMC strategies in life sciences. You'll engage with industry leaders, drive software adoption, and shape market narratives to enhance product lifecycle management and ope...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead complex engineering projects across diverse sectors, ensuring timely delivery and client satisfaction. Collaborate with cross-functional teams, manage resources, and mentor staff while driving bu...

3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$150K - $180K *

Engage as a senior client partner, driving revenue and retention for small business clients. Lead a high-volume portfolio with a focus on strategic growth, innovation, and AI adoption, while shaping m...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$135K - $178K *

Transform data governance by leading initiatives that bridge legal compliance, data security, and technology operations. Drive innovative self-service workflows while ensuring compliance across divers...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $100K *

Unlock potential by leading complex food service programs, ensuring operational excellence and financial success while collaborating across divisions and engaging with customers at a senior level...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$139K - $174K *

Join a team that's shaping the future of mission-critical projects. Lead cross-functional teams, oversee deliverables, and enhance client relationships while managing complex, large-scale projects in...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$65K - $110K *

Manage and oversee construction projects, ensuring quality delivery, profitability, and timely completion. Collaborate across departments, develop team members, and maintain strong customer relationsh...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $145K *

Shape the future of energy efficiency by leading complex client programs and strategic initiatives. Drive portfolio success through operational excellence, financial performance, and strong client rel...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$188K - $282K *

Drive design excellence in fintech by leading a team to enhance payment, billing, and timekeeping solutions. Collaborate with cross-functional partners to shape user experiences that empower legal pro...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$130K - $160K *

Drive program success by coordinating cross-functional teams, managing reporting, and optimizing engagement strategies for a global enterprise account, ensuring alignment with client goals and employe...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Oversee strategic planning and execution of large-scale construction projects, ensuring timely completion within budget and safety standards. Lead field operations and coordinate with teams to deliver...

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$85K - $100K *

Join a team that's shaping the future of land development through innovative engineering solutions. Collaborate with diverse clients and lead projects from concept to completion, enhancing urban lands...

3 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$85K - $95K *

Drive the end-to-end delivery of complex curriculum projects, collaborating across teams to ensure high-quality outcomes that meet business and learner needs while managing risks and stakeholder expec...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$230K - $280K *

Champion analytical development by leading strategy and execution for pipeline products. Drive compliance and quality control while building a high-performing team in a dynamic environment focused on...

United StatesRemote

3 days ago

  •   15+ years exp.  •   Information Technology

$120K - $145K *

Lead enterprise-scale Sirion CLM implementations, managing delivery, client relationships, and cross-functional teams. Drive program success through governance, financial management, and pre-sales sup...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Legal & Accounting

$159K - $211K *

Join us in transforming quality operations by leading a robust PACE quality program, ensuring compliance and care excellence while collaborating cross-functionally to enhance participant outcomes and...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$200K - $230K *

Unlock potential by leading a dynamic team in cloud services management, ensuring high availability and security while driving innovation through AI tools and fostering a DevOps culture for continuous...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$200K - $300K *

Lead the charge in managing large-scale mission-critical projects, ensuring strategic execution, financial performance, and team development. Drive client satisfaction and operational excellence in fa...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$110K - $130K *

Drive strategic leadership for complex energy projects, ensuring compliance and stakeholder engagement while managing multi-site environmental permitting and regulatory processes across the U.S. Lead...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$198K - $298K *

Lead the global strategy and governance for investigator grants, ensuring compliance and financial accuracy across regions. Drive integration of site payment processes and build scalable operations wh...

United StatesRemote

Today

  •   15+ years exp.  •   Healthcare

$138K - $180K *

Lead the delivery of complex DevOps and cloud infrastructure projects, driving collaboration across engineering teams. Manage risks, dependencies, and execution plans to ensure successful project outc...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.