Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$148K - $175K *

Join a dynamic team as a Senior Project Manager, overseeing complex data center projects. Drive client engagement, ensure seamless collaboration, and deliver exceptional results while upholding high s...

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$155K - $210K *

Lead complex programs and strategic client engagements, driving technology transformation and sustainable business value. Act as a trusted adviser to C-level stakeholders, shaping program vision and e...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $135K *

Partner with us to drive strategic initiatives across Support Services and data centers. This role ensures effective project management, governance, and measurable outcomes in a dynamic environment, f...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$90K - $110K *

Transform project delivery by leading software implementations, ensuring timely and budget-friendly outcomes while fostering strong stakeholder relationships and navigating complex environments with c...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$115K - $163K *

Transform project delivery by leading complex construction initiatives, ensuring on-time and on-budget completion while fostering client relationships and guiding teams through all project phases from...

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$101K - $112K *

Lead the charge in managing complex projects within the Education portfolio, ensuring effective coordination across teams and stakeholders while driving impactful outcomes in higher education and appl...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$63K - $111K *

Champion project execution by overseeing plans, budgets, and schedules. Collaborate with teams to ensure quality and adherence to requirements while driving project success and addressing challenges e...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Real Estate & Construction

$80K - $95K *

Transform eDiscovery management by driving operational excellence, ensuring timely project delivery, and enhancing workflow efficiency. Collaborate with stakeholders to uphold quality standards and fo...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$120K - $140K *

Champion project success by managing cross-functional initiatives, ensuring timely delivery of new products, packaging, and promotions. Collaborate with diverse teams to drive accountability and strea...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Food & Beverages

$103K - $146K *

Transform project execution by overseeing multi-million dollar mechanical construction initiatives, ensuring timely delivery, budget adherence, and fostering strong team and client relationships throu...

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$157K - $283K *

Lead the charge in managing large-scale transportation engineering projects, overseeing all phases from initiation to completion. Leverage your expertise to drive project success and ensure compliance...

United StatesRemote

3 days ago

  •   15+ years exp.  •   Real Estate & Construction

$150K - $180K *

Optimize program management across the Customer Experience organization, ensuring strategic alignment and operational excellence. Lead cross-functional teams, establish governance frameworks, and driv...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$177K - $221K *

Optimize patient access by leading cross-functional initiatives, managing operational priorities, and driving accountability for results in a dynamic healthcare environment. Collaborate with stakehold...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead multidisciplinary teams to manage medical communications projects from inception to completion, ensuring client satisfaction, budget adherence, and timely delivery of high-quality content and ser...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

$95K - $115K *

Lead the charge in managing complex projects and mentoring teams while ensuring client satisfaction and technical excellence. Drive project success through effective communication and coordination wit...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $135K *

Lead the charge in developing and managing enterprise proposals and plans, ensuring compliance and quality across submissions. Collaborate with cross-functional teams to enhance win strategies and dri...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Champion project success by managing software implementations across diverse teams. Drive efficiency and functionality through effective communication, risk management, and strategic planning, ensurin...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$167K - $245K *

Accelerate IT innovation by leading operations and engineering teams that enhance productivity and security for a 500+ remote workforce, while embedding AI and automation into core processes for optim...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Information Technology

$88K - $105K *

Engage in the execution and management of multifaceted projects within a complex program, ensuring compliance with contract standards while enhancing customer relations and delivering technical suppor...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$110K - $130K *

Lead the charge in managing complex projects within our EPMO, ensuring timely delivery and alignment with strategic goals while fostering collaboration across diverse teams and stakeholders...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$155K - $205K *

Champion process excellence by optimizing workflows and driving cross-functional improvements. Collaborate with teams to enhance operational efficiency, reduce costs, and elevate service quality throu...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Energy & Utilities

$117K - $158K *

Unlock potential by leading complex client engagements, ensuring timely delivery, budget management, and effective resource utilization while navigating challenges in a dynamic environment. Empower te...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$100K - $120K *

Optimize your career as a Technical Project Manager, overseeing equipment procurement and supply chains. Collaborate with cross-functional teams, manage budgets, and negotiate contracts to ensure proj...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $150K *

Champion integrated project management for complex pharmaceutical advertising, leading cross-functional teams to ensure timely delivery within scope and budget while mentoring junior staff and enhanci...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $182K *

Join a team that's dedicated to transforming business needs into innovative software solutions. Collaborate with clients and developers to ensure high satisfaction and successful adoption while advanc...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.