Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$196K - $294K *

Empower the EMD franchise by leading learning strategies and operational execution, driving measurable impact across commercial, medical, and market access teams while fostering a high-performing cult...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$76K - $115K *

Join a team that's shaping the future of customer education through innovative instructional design. Leverage your expertise to create engaging learning experiences that empower users and drive succes...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Shape the future of quality assurance by managing and enhancing the Quality Control program, ensuring compliance and excellence through collaboration with project teams and oversight of inspections an...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Champion operational excellence by leading logistics teams to enhance efficiency, safety, and quality. Drive performance through effective management and motivation, ensuring seamless coordination and...

Reposted 4 days ago

  •   Less than 5 years exp.  •   Transportation

$87K - $230K *

Join a team that's driving successful Workday implementations by leading cross-functional projects, managing risks, and fostering client relationships to achieve clear business outcomes and high-quali...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Explore innovative AI workflow solutions aimed at enhancing business processes. Collaborate with various teams to identify challenges, prototype solutions, and guide projects from conception to produc...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$155K - $180K *

Drive successful delivery of complex, multi-year programs in a dynamic environment. Collaborate with cross-functional teams to manage scope, budget, and timelines while ensuring client satisfaction an...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $130K *

Join a dynamic team to manage multiple design-build projects, ensuring budget, schedule, and quality standards are met while fostering client relationships and promoting safety. Drive project success...

2 weeks ago

  •   5 - 7 years exp.  •   Staffing

$125K - $150K *

Lead the charge in driving new business acquisition and expanding opportunities across Consumer Goods, Retail, and Travel sectors. Leverage industry expertise to build relationships and position as a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Champion innovative solutions as a Senior Implementation Project Manager, leading complex software implementations and driving customer success through effective project management and collaboration a...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$148K - $210K *

Join us to lead and grow the power engineering team, managing high-level projects in substation design and grid integration. Drive technical excellence and strategic initiatives while shaping our serv...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Technical Services

$94K - $114K *

Support project risk management initiatives across various sectors, collaborating with stakeholders to identify, analyze, and mitigate risks. Lead qualitative and quantitative assessments to enhance p...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$190K - $228K *

Drive enterprise Quality and Regulatory governance for U.S. operations, ensuring compliance with FDA regulations and overseeing manufacturing quality in the therapeutic radiopharmaceutical sector whil...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$275K - $325K *

Lead the charge in building and managing a construction banking sector, driving strategy, partnerships, and product development while overseeing P&L and fostering key relationships to establish Flex a...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $160K *

Lead the charge in quality and validation readiness for complex programs, uniting Engineering, Product, and Customer Success teams. Utilize AI and automation to streamline processes, enhance delivery...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$143K - $197K *

Accelerate progress at a global scale by leading business development initiatives, managing teams, and crafting strategic plans to drive revenue growth while navigating complex client relationships an...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$145K - $160K *

Lead the charge in transforming member support by defining strategy, enhancing team performance, and integrating AI solutions. Drive operational excellence while fostering a culture of empathy and acc...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$198K - $330K *

Lead a dynamic team to shape technology portfolio management, ensuring strategic alignment and delivery excellence across product and engineering initiatives while fostering collaboration and accounta...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Unlock potential by leading client teams to drive retention and growth. Collaborate cross-functionally to shape strategic market positioning and nurture executive relationships, all while cultivating...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$135K - $160K *

Lead the charge in transforming legal operations by advising corporate legal departments on strategy, technology, and process improvements. Drive complex engagements, build trusted relationships, and...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$96K - $125K *

Join a team that's focused on enhancing delivery across cross-functional initiatives, ensuring timely execution and risk management. Collaborate with diverse teams to drive improvements and elevate cu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$145K - $222K *

Deliver impactful leadership by managing multi-discipline nuclear projects, ensuring alignment across teams, and guiding successful execution from design to closeout while maintaining client relations...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$190K - $220K *

Champion innovation and execution as you lead product management across diverse e-commerce channels. Drive strategic roadmaps, manage global teams, and deliver cutting-edge solutions that enhance cust...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's dedicated to managing complex programs, ensuring client satisfaction and operational efficiency. Lead daily operations, supervise staff, and contribute to strategic initiatives whil...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$191K - $247K *

Develop and oversee advanced capabilities in Commercial Learning & Development, driving strategy, implementation, and continuous improvement to enhance field performance and support business objective...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.