Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$198K - $298K *

Elevate your career by leading global investigator grants strategy and operations. Drive integration, governance, and financial controls while collaborating with cross-functional teams to ensure compl...

United StatesRemote

Today

  •   15+ years exp.  •   Healthcare

$145K - $175K *

Join a team that's redefining AI-driven solutions by leading product development for an innovative tech concierge. Drive the evolution of agent capabilities, ensuring quality and reliability while col...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Optimize engagement and monetization strategies for an AI-driven product, transforming customer interactions into measurable growth. Lead cross-functional teams to innovate and implement effective use...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $115K *

Transform your career by leading financial strategy and operations for innovative service lines. Collaborate with senior leaders to enhance profitability, oversee budgeting, and drive growth initiativ...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Transform global partner strategies to drive revenue and market share through innovative go-to-market models, collaborating with key stakeholders to establish impactful partnerships and optimize sales...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$180K - $200K *

Accelerate progress at regional Professional Services by leading teams, driving growth and quality in consulting engagements while fostering strategic partnerships and developing innovative service of...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$95K - $150K *

Pioneer the future of HR technology by leading cross-functional teams to define and deliver innovative solutions in Global Mobility and Talent Management, ensuring alignment across stakeholders and se...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$95K - $115K *

Drive excellence in Life Sciences construction by overseeing project execution, ensuring safety compliance, and maintaining quality standards. Your leadership will be key in managing teams and deliver...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $180K *

Elevate your career by leading client relationships and driving revenue growth for consumer product brands in the D2C ecommerce space. Utilize your expertise to coach teams, innovate strategies, and o...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$161K - $242K *

Join a team that's driving strategic initiatives and digital transformation. Collaborate with senior leaders to tackle complex challenges, influence decision-making, and ensure successful execution of...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$102K - $152K *

Transform executive support by leading a dynamic team of EAs, enhancing processes, and driving strategic initiatives that align with company goals while fostering a collaborative culture...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Lead the growth of datacom solutions by building strong teams and partnerships. Develop inventory strategies and execute market initiatives across an 8-state region, driving collaboration and relation...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$220K - $290K *

Accelerate the development of autonomous systems by leading systems engineering strategies, aligning cross-functional teams, and ensuring rigorous safety and performance standards throughout the produ...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$132K - $165K *

Shape the future of billing and collections by driving product strategy and enhancing user experiences. Collaborate with cross-functional teams to deliver reliable payment solutions that boost revenue...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$137K - $245K *

Shape the future of physical operations by driving AI-powered product innovation. Collaborate across teams to identify customer needs, prototype solutions, and deliver impactful products that enhance...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$137K - $245K *

Lead the charge in driving strategic initiatives and product innovation within the Telematics Business Unit, enhancing core offerings and exploring new market opportunities through hands-on collaborat...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Drive innovative process design by leading teams, mentoring talent, and ensuring compliance with industry standards. Collaborate with clients to refine deliverables and enhance workflows, fostering co...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $180K *

Drive impactful financial solutions by leading teams and transforming data into strategic insights. Collaborate with stakeholders to enhance processes and deliver high-quality results that support inf...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Champion operational excellence by leading communication strategies and process improvements. Collaborate with leadership and teams to ensure effective information flow and accountability, driving ini...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Unlock potential by leading client relationships and driving strategic measurement initiatives. Manage a diverse portfolio, ensuring retention and growth while guiding teams to deliver impactful marke...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$190K - $225K *

Drive business development strategy for military programs, leading a team to enhance sales growth and customer engagement. Collaborate across departments to ensure product alignment with market needs...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Lead the charge in multidisciplinary design delivery for data center projects, ensuring buildable, cost-effective designs from planning through construction. Collaborate with teams to meet tenant need...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $180K *

Partner with us to drive innovative solutions in architecture, engineering, and construction. You'll collaborate across disciplines, leveraging your expertise to optimize project delivery and exceed c...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$80K - $95K *

Drive excellence in healthcare construction projects by leading teams, managing schedules, and ensuring safety and quality standards. Collaborate with diverse stakeholders to deliver impactful results...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$107K - $145K *

Drive growth by identifying and securing new business opportunities in risk management and medical education. Collaborate with teams to develop proposals, manage sales pipelines, and ensure alignment...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.