Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$150K - $180K *

Reimagine client partnerships by managing complex relationships, driving performance, and leading recovery strategies. Collaborate with executives to ensure client success and identify growth opportun...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $152K *

Transform project management by leading medium to large-scale E,F&I projects. Drive customer satisfaction and achieve financial targets while collaborating with cross-functional teams to ensure qualit...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$150K - $180K *

Champion the Brand P&L by leading strategic marketing initiatives, enhancing brand visibility, and achieving sales targets in the Home and Garden sector through omnichannel strategies and data-driven...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$250K - $350K *

Lead the development of a clinical supply consulting practice, combining expertise in forecasting, planning, and optimization to enhance decision-making for sponsors. Drive innovation and commercial g...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$82K - $172K *

Champion eDiscovery project management by leading high-visibility initiatives for the DOJ. Collaborate with legal teams to ensure seamless project execution across all EDRM phases, delivering quality...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Lead project management efforts, ensuring quality delivery on time and within budget. Oversee project scope, client communications, and team coordination while driving successful outcomes for strategi...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $125K *

Manage a team of medical writers to develop impactful scientific content, ensuring accuracy and compliance. Collaborate with clients and cross-functional teams to drive medical strategies and delivera...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$170K - $205K *

Unlock the potential of our Pro offering by leading product strategy and roadmap. Collaborate across teams to enhance customer experiences for short-term rental operators and HOAs, ensuring scalable s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$100K - $150K *

Drive financial strategy by owning planning, forecasting, and analysis. Collaborate with leadership to provide insights that inform decisions, while building robust models in Excel to guide revenue an...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $151K *

Lead the development and management of Reality Capture capabilities, enhancing design services through innovative technology and expert collaboration. Drive project integration, operational excellence...

4 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$88K - $105K *

Innovate and lead architectural projects from concept to completion, ensuring timely delivery and client satisfaction. Collaborate with diverse teams, manage budgets, and mentor junior staff while mai...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$115K - $138K *

Transform project delivery by leading complex, multi-phase initiatives. Oversee cross-functional teams, manage budgets, and ensure timely completion while aligning outcomes with client expectations an...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$150K - $180K *

Elevate your career by driving efficiency and optimizing processes across Product & Engineering teams. Collaborate with cross-functional teams to implement Agile methodologies and enhance release mana...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$95K - $115K *

Oversee complex manufacturing operations initiatives, driving project management from inception to completion. Collaborate across teams to optimize production capacity and meet Hyperscale customer dem...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$88K - $105K *

Join a team that's dedicated to delivering high-quality design-build projects. As a Senior Project Engineer, you'll oversee project execution, mentor junior staff, and ensure timely completion from de...

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$170K - $220K *

Lead continuous improvement initiatives across QSR operations, driving cultural transformation and operational excellence. Manage CI strategies, develop leaders, and ensure alignment with enterprise g...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Pioneer customer health and retention strategies by leading cross-functional teams to enhance customer experience, leveraging AI and data insights to drive actionable outcomes and ensure customer succ...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Join a dynamic team as a senior leader, driving client relationships and revenue growth in lead-generation sectors. You'll manage a diverse portfolio, ensuring lead quality and speed while leveraging...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Unlock your potential as a Program Manager, leading federal service contracts and driving operational excellence. Collaborate with teams to ensure quality delivery, financial performance, and customer...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$120K - $130K *

Lead multi-site project implementations, coordinating teams and maintaining schedules to ensure successful delivery across phases. Drive stakeholder engagement and validate readiness for deployment in...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$163K - $261K *

Shape the future of electrification services by leading operations across the West U.S. region, driving performance excellence, and managing nationwide digital automation initiatives while advancing r...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$70K - $105K *

Manage and oversee multiple medical communications projects, ensuring timely delivery and operational excellence while collaborating with cross-functional teams and clients to drive impactful healthca...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $200K *

Lead the charge in developing integrated media strategies and client partnerships across pharmaceutical and life sciences accounts, driving business growth and ensuring exceptional delivery and client...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$115K - $150K *

Join a team that's dedicated to guiding recovery efforts post-disaster. Lead a multi-disciplinary team, leveraging your expertise in FEMA programs to support local governments through complex recovery...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$130K *

Shape the future of telecommunications by leading complex, large-scale projects. Drive strategic planning, manage executive communications, and ensure program success through innovative solutions and...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.