Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$118K - $197K *

Lead the charge in executing a robust Third Party Risk Management program, driving governance, oversight, and collaboration across teams to enhance risk management effectiveness and performance throug...

3 days ago

  •   8 - 10 years exp.  •   Business Services

$150K - $180K *

Elevate your career as a Group Director, leading B2B client success and team performance. Drive client retention and growth, enhance strategic initiatives, and shape the division's vision in a dynamic...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Accelerate your career by leading SAP Cloud ERP implementations, managing scope, schedule, and quality across projects. Collaborate with diverse teams to ensure successful delivery and drive customer...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$130K - $155K *

Join a team that's dedicated to driving operational excellence and project delivery. Lead a diverse portfolio, enhance agency workflows, and foster collaborative relationships across departments to en...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by leading a global team in Trust Services, enhancing client relationships, and driving operational excellence. Shape the future of AI-powered security solutions while ensuring top-ti...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Elevate your project management career by leading a strategic platform within investor client coverage, enhancing client engagement and driving technology integration across CBRE's commercial real est...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$120K - $125K *

Lead the charge in mobilizing significant carbon transactions across Latin America, managing multi-stakeholder relationships and driving strategic initiatives to support forest protection programs und...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$190K - $220K *

Champion financial excellence by leading a dynamic team, driving strategic analysis, and leveraging AI to enhance decision-making for a diverse portfolio of clients in a fast-paced, remote environment...

RemoteRemote

3 weeks ago

  •   11 - 15 years exp.  •   Business Services

$132K - $199K *

Lead the charge in driving Professional Services sales and client success within the US Public Sector, collaborating across teams to maximize revenue, enhance client relationships, and ensure successf...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $160K *

Drive project success by managing integrated delivery across AI task orders, overseeing multidisciplinary teams, and ensuring adherence to quality standards while maintaining project roadmaps and sche...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $200K *

Lead the translation of investment strategies into tailored client policies, ensuring alignment with firm philosophy. Drive portfolio reviews, client communication, and advisor training while collabor...

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Lead end-to-end client engagements for complex AI and digital projects, managing multiple implementations while ensuring timely delivery and exceeding client expectations. Collaborate with cross-funct...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Lead the charge in program management excellence, ensuring seamless operations and compliance across diverse teams while supporting critical Air Force contract initiatives and rapid-response readiness...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$150K - $180K *

Reimagine client partnerships by managing complex relationships, driving performance, and leading recovery strategies. Collaborate with executives to ensure client success and identify growth opportun...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $152K *

Transform project management by leading medium to large-scale E,F&I projects. Drive customer satisfaction and achieve financial targets while collaborating with cross-functional teams to ensure qualit...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$150K - $180K *

Champion the Brand P&L by leading strategic marketing initiatives, enhancing brand visibility, and achieving sales targets in the Home and Garden sector through omnichannel strategies and data-driven...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$250K - $350K *

Lead the development of a clinical supply consulting practice, combining expertise in forecasting, planning, and optimization to enhance decision-making for sponsors. Drive innovation and commercial g...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$82K - $172K *

Champion eDiscovery project management by leading high-visibility initiatives for the DOJ. Collaborate with legal teams to ensure seamless project execution across all EDRM phases, delivering quality...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Lead project management efforts, ensuring quality delivery on time and within budget. Oversee project scope, client communications, and team coordination while driving successful outcomes for strategi...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $125K *

Manage a team of medical writers to develop impactful scientific content, ensuring accuracy and compliance. Collaborate with clients and cross-functional teams to drive medical strategies and delivera...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$170K - $205K *

Unlock the potential of our Pro offering by leading product strategy and roadmap. Collaborate across teams to enhance customer experiences for short-term rental operators and HOAs, ensuring scalable s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$100K - $150K *

Drive financial strategy by owning planning, forecasting, and analysis. Collaborate with leadership to provide insights that inform decisions, while building robust models in Excel to guide revenue an...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $151K *

Lead the development and management of Reality Capture capabilities, enhancing design services through innovative technology and expert collaboration. Drive project integration, operational excellence...

4 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$88K - $105K *

Innovate and lead architectural projects from concept to completion, ensuring timely delivery and client satisfaction. Collaborate with diverse teams, manage budgets, and mentor junior staff while mai...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$115K - $138K *

Transform project delivery by leading complex, multi-phase initiatives. Oversee cross-functional teams, manage budgets, and ensure timely completion while aligning outcomes with client expectations an...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.