Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$88K - $105K *

Elevate design excellence by leading complex projects from inception to completion. Collaborate with clients, manage budgets, and ensure timely delivery while fostering a results-driven team environme...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$134K - $224K *

Shape the future of clinical research technology by leading cross-functional teams to develop innovative solutions that enhance user experience and drive operational excellence in global clinical tria...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$77K - $91K *

Shape the future of project management by leading initiatives that exceed expectations, ensuring timely communication, and fostering collaboration across teams while managing risks and delivering resu...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$180K - $220K *

Advance global procurement initiatives by leading sourcing strategies for MRO and automotive parts. Drive operational excellence, enhance supplier relationships, and ensure compliance while achieving...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Transportation

$110K - $130K *

Accelerate progress at national partnerships by leading fundraising initiatives, securing multi-million-dollar commitments, and cultivating relationships with corporate and foundation leaders to suppo...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$115K - $135K *

Shape the future of our Accounting Operations by leading a dynamic team, ensuring accuracy and efficiency in financial processes, and driving improvements through automation and AI integration...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$100K - $120K *

Join us in managing complex EPC interfaces and project execution for a critical microgrid initiative. Collaborate across teams to ensure timely delivery and adherence to safety standards while standin...

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$120K - $150K *

Transform financial operations by leading a dynamic team, ensuring accurate reporting, and driving strategic decisions that enhance value and growth in a fast-paced healthcare environment. Partner clo...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Join us to lead national process improvement initiatives, fostering operational excellence across diverse teams. Drive efficiencies, document workflows, and empower stakeholders, ensuring alignment wi...

Reposted 6 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$230K - $280K *

Lead a high-performing team to enhance Solutions Consulting, drive cross-functional collaboration and ensure the success of strategic accounts through innovative, accountable deal execution and contin...

RemoteRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$145K - $175K *

Elevate enterprise application strategy by leading a dynamic team to align technology with business goals, ensuring optimal portfolio management, user experience, and measurable outcomes for sustained...

4 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$101K - $154K *

Shape product strategy and commercialization efforts, ensuring alignment with market trends and customer needs. Drive product development, marketing initiatives, and cross-functional collaboration to...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Join us to empower senior leaders by managing complex projects, client contracts, and travel arrangements. Your proactive support will enhance team efficiency in a fully virtual environment, fostering...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Business Services

$140K - $155K *

Engage with strategic enterprise clients to drive retention, growth, and satisfaction. Lead account strategy, advise stakeholders, and deliver measurable outcomes while mentoring team members and fost...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$170K - $190K *

Transform the future of enterprise deployment by leading SAP S/4HANA initiatives across multiple regions. Drive strategic alignment, ensure operational readiness, and deliver measurable outcomes while...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion the delivery of large-scale data center projects, overseeing field operations, client coordination, and compliance across multiple sites. Drive project success through effective management of...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$150K - $180K *

Lead the charge in optimizing marketing operations to drive developer adoption, pipeline growth, and revenue. Oversee systems, processes, and insights while collaborating with cross-functional teams t...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$68K - $113K *

Lead project coordination efforts by ensuring effective communication and management of materials, schedules, and documentation. Collaborate with teams to streamline processes and enhance project effi...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $215K *

Collaborate with senior leaders to design and implement global HR strategies, driving organizational performance and employee engagement while leading a team of HR professionals in a dynamic environme...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Advance your career by leading substation projects, managing design and execution for diverse clients. Collaborate with teams to ensure quality, safety, and efficiency while driving operational improv...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$87K - $115K *

Transform critical facilities by providing technical leadership in commissioning projects. Collaborate with diverse teams to ensure compliance, manage schedules, and execute testing for complex electr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$150K - $180K *

Lead the charge in transforming partner data operations and integrations, ensuring efficient case resolution and proactive partner enablement. Drive automation, establish standards, and foster a produ...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Lead the charge in shaping global healthcare packaging design. As a Principal Design Program Manager, you'll establish frameworks and standards, drive strategic decisions, and ensure seamless collabor...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Champion the successful delivery of projects and technology initiatives by coordinating cross-functional teams and managing risks, ensuring timely and high-quality outcomes that align with business ob...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$77K - $126K *

Take ownership of managing construction projects, ensuring timely, on-budget delivery while collaborating with vendors and adhering to guidelines. Drive process improvements and maintain comprehensive...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.