Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$92K - $98K *

Take ownership of federal proposal efforts, coordinating cross-functional teams to develop compliant, compelling proposals that align with strategic growth objectives and enhance organizational effect...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in transforming portfolio management practices, enhancing strategic alignment, and fostering high-performing teams. Collaborate with executives to drive technology investments that del...

2 weeks ago

  •   8 - 10 years exp.  •   Transportation

$225K - $250K *

Engage with business owners navigating M&A transactions, providing integrated planning and support. Collaborate with deal teams to ensure seamless transitions and optimize after-tax outcomes during cr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$168K - $281K *

Lead the charge in Proactive Defense Operations, transforming threat data into automated defenses. Drive strategy, team performance, and operational excellence while collaborating across functions to...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$115K - $120K *

Lead the charge in driving operational excellence and strategic enablement across global Inside Sales teams, enhancing commercial effectiveness and delivering exceptional client value through innovati...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Empower the development of innovative banking solutions by driving product strategy, collaborating across teams, and delivering scalable capabilities that enhance customer experiences and meet busines...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$140K - $180K *

Transform the digital manufacturing landscape by driving sales growth and market expansion. Collaborate across teams to develop strategies, support federal opportunities, and enhance customer value th...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$100K - $140K *

Drive innovative media strategies for healthcare clients, leveraging audience insights and performance data. Collaborate with cross-functional teams to enhance planning processes and deliver impactful...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Unlock potential by leading client engagements in higher education, ensuring delivery excellence and fostering executive relationships. Drive project success through oversight, escalation management...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$140K - $180K *

Lead the execution of complex IT infrastructure projects, ensuring mission success for critical U.S. Coast Guard programs. Collaborate with stakeholders and manage resources to deliver seamless techno...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$85K - $124K *

Drive impactful SAP projects as a Project Manager/Scrum Master, leading teams to deliver innovative solutions. Collaborate with stakeholders, manage product backlogs, and ensure agile practices to mee...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$143K - $179K *

Lead cross-functional initiatives, optimizing governance and operational readiness for programs. Collaborate with stakeholders to enhance portfolio execution, reporting, and PMO capabilities, driving...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Drive mobile engineering excellence across diverse product teams, ensuring strategic direction, fostering collaboration, and enhancing delivery. Lead managers, shape architecture, and cultivate a prod...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$120K - $140K *

Transform your career by leading complex design change projects from inception to execution. Collaborate with cross-functional teams, manage substantial budgets, and drive innovation in a fast-paced e...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$75K - $150K *

Transform client initiatives by leading complex projects from planning to execution. Collaborate with teams and stakeholders to ensure timely, on-budget delivery while maintaining high standards of qu...

Yesterday

  •   8 - 10 years exp.  •   Media

$85K - $102K *

Drive project success by leading teams, managing schedules, and ensuring quality outcomes in civil energy projects. Collaborate with stakeholders to align on goals and navigate complexities throughout...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Elevate your career by leading project teams to deliver quality civil infrastructure solutions. Drive project success through strategic planning, risk management, and effective communication with stak...

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Join a team that's dedicated to delivering successful projects on time and on budget. As a key player, you'll drive project planning, coordinate with stakeholders, and ensure effective communication t...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$178K - $338K *

Redefine financial planning with leadership in Workday Adaptive Planning implementations. Collaborate across teams to enhance reporting, optimize processes, and drive enterprise performance management...

RemoteRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$80K - $95K *

Transform project execution by leading design and construction initiatives. Manage budgets, timelines, and client expectations while fostering collaboration and ensuring project excellence from start...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$88K - $105K *

Empower successful project delivery by managing engineering solutions that exceed client expectations. Collaborate with cross-functional teams to oversee project budgeting and scheduling while ensurin...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $140K *

Advance your career by leading project delivery and operational excellence in a dynamic healthcare agency. Collaborate across teams, manage client relationships, and drive innovative solutions to enha...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in optimizing our Adaptive Planning platform, ensuring accurate data management and seamless integrations. Collaborate with cross-functional teams to enhance reporting and streamline f...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$68K - $103K *

Engage with a dynamic team to drive successful execution of HEOR projects, ensuring timely delivery and high-quality outcomes through strategic portfolio management and collaboration with cross-functi...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $225K *

Oversee complex industrial construction projects, ensuring safety, quality, and timely completion. Lead multidisciplinary teams, manage contractor performance, and coordinate with stakeholders to achi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.