Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Project Manager (Data Projects)
$120K - $125K *
Transform data analytics initiatives by leading multiple projects, engaging stakeholders, and driving solutions from inception to delivery. Collaborate with technical teams to ensure alignment with mi...
2 weeks ago
Project Manager (MEP Engineering)
$130K - $170K *
Shape the future of capital projects by leading multi-discipline teams to deliver complex design packages, ensuring quality and client satisfaction across diverse sectors including healthcare and gove...
2 weeks ago
Project Manager II, Global Project Leadership
$95K - $115K *
Drive the successful delivery of complex global clinical trials, overseeing cross-functional teams and ensuring compliance with GCP and regulatory standards while managing budgets and timelines to exc...
1 month ago
Senior Vice President, Project Management
$180K - $220K *
Pioneer enterprise project delivery by leading a high-performing team, ensuring strategic execution, financial performance, and operational readiness across complex programs and portfolios while foste...
2 days ago
$110K - $130K *
Lead cross-functional project execution in Medication Contracting, translating strategic priorities into actionable plans. Drive improvements, manage risks, and enhance collaboration across teams to e...
1 week ago
$90K - $140K *
Join a team that's driving project success by leading technical initiatives, resolving complex challenges, and aligning outcomes with client objectives. Your expertise will enhance profitability and o...
2 weeks ago
$106K - $125K *
Transform project delivery by managing timelines, budgets, and teams to meet client objectives. Collaborate with stakeholders to ensure quality and compliance while driving continuous improvement in p...
Reposted yesterday
$93K - $110K *
Join a team that's dedicated to delivering exceptional project management for restaurant construction. Oversee projects from inception to completion, ensuring client satisfaction and adherence to time...
6 days ago
Senior Project Manager, Marketing PMO
$110K - $130K *
Lead complex, cross-functional marketing initiatives from planning to execution, driving accountability and collaboration across teams while enhancing project management processes and methodologies fo...
3 weeks ago
Senior Project Manager, Oncology
$147K - $220K *
Optimize project delivery by leading clinical study initiatives, ensuring quality, budget, and timelines are met. Collaborate with teams and clients to drive success in complex global trials while man...
Reposted 1 week ago
$147K - $220K *
Drive the success of clinical study projects by managing timelines, budgets, and quality standards. Collaborate with teams and clients to ensure project objectives are met while fostering a culture of...
4 weeks ago
Project Manager - Power Solutions
$165K - $185K *
Grow your career with us by leading complex electrical power solutions projects. Collaborate with diverse teams to deliver innovative solutions for mission-critical facilities, ensuring projects meet...
4 weeks ago
$80K - $95K *
Champion project success by managing healthcare architecture initiatives from inception to completion. Lead diverse teams, engage clients, and ensure compliance with industry standards while deliverin...
4 days ago
Implementation Project Manager
$90K - $110K *
Champion client success by leading complex implementations, managing risks, and ensuring operational readiness. Collaborate with executive stakeholders to deliver projects on time while maintaining hi...
Reposted 2 weeks ago
$95K - $115K *
Champion clinical trial success by leading cross-functional teams, ensuring timely project execution, and maintaining high standards of quality and compliance. Collaborate with stakeholders to drive i...
3 days ago
$110K - $130K *
Shape the future of healthcare by leading complex implementations across provider and payor organizations. Drive project success through collaboration, strategic planning, and innovative solutions whi...
2 weeks ago
Senior Project Manager, Client Services
$110K - $130K *
Drive client satisfaction as a Senior Project Manager, overseeing eDiscovery projects, managing budgets, and consulting on best practices. Lead teams, enhance workflows, and ensure timely delivery whi...
1 week ago
Manager Project Management (PMO) North America
$108K - $130K *
Optimize project management processes by leading governance, performance metrics, and cross-functional collaboration to enhance operational efficiency and drive business performance across the organiz...
2 days ago
$80K - $90K *
Elevate project management excellence by leading complex initiatives that drive strategic improvements and enhance operational efficiency across the organization. Collaborate with stakeholders to ensu...
Yesterday
$140K - $185K *
Transform project delivery by managing IT initiatives for California agencies. Collaborate with state staff to ensure timely, budget-compliant outcomes while leveraging Agile methodologies and large s...
3 weeks ago
$95K - $115K *
Lead the charge in managing complex projects, ensuring alignment with strategic goals, optimizing resources, and enhancing performance. Mentor teams while driving project success within budget and tim...
Yesterday
$125K - $150K *
Lead the charge in overseeing project financials and operations, mentoring teams, and ensuring profitability across multiple construction projects. Drive strategic planning and resource allocation whi...
1 week ago
$88K - $154K *
Champion the successful execution of field projects, ensuring adherence to budget, timeline, and quality standards while leading teams and coordinating with stakeholders in a dynamic environment...
1 week ago
$110K - $130K *
Engage your expertise to lead bridge and structural projects from planning to completion. Manage multidisciplinary teams, maintain client relationships, and drive practice growth across Massachusetts...
2 weeks ago
Senior Project Manager / SCRUM Master
$111K - $192K *
Unlock potential by leading Agile delivery for technology modernization initiatives. Drive project planning, stakeholder coordination, and disciplined management to ensure multidisciplinary teams achi...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.