Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$200K - $220K *

Lead product management for an innovative infrastructure automation platform, driving strategy and vision while managing a team of senior product managers. Collaborate cross-functionally to enhance cu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Manage technical standards for topographic survey and data collection, ensuring quality and accuracy in methodologies. Collaborate with project teams to deliver reliable geospatial information for eng...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Shape the future of manufacturing by leading capital projects and automation initiatives. Drive continuous improvement and provide technical guidance to a high-performing team, ensuring successful exe...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$160K - $200K *

Join a team that's redefining forensics and collections globally. Lead a skilled team, enhance operational efficiency, and drive client engagement while ensuring compliance and defensibility across re...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Legal & Accounting

$260K - $265K *

Innovate the future of hospitality services by unifying existing platforms into a cohesive offering. Collaborate with leadership to define, build, and market a new service model that meets client need...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $180K *

Pioneer sustainable growth by leading strategic initiatives, strengthening client relationships, and enhancing operational excellence in commercial construction. Drive performance and cultivate top ta...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$99K - $232K *

Lead the charge in transforming P&C insurance operations by guiding teams, enhancing service delivery, and implementing technology solutions to streamline processes and improve client engagement acros...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$99K - $232K *

Analyze and enhance service operations in the P&C insurance sector. Lead teams in technology solution design, streamline processes, and mentor staff to improve client engagements and service delivery...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$95K - $115K *

Lead a high-performing project management team, driving operational excellence and customer satisfaction while ensuring efficient project execution and strong stakeholder relationships throughout the...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$152K - $225K *

Develop your career by leading the end-to-end lifecycle of Supply Planning applications. Collaborate with teams to drive product vision, mentor staff, and ensure high-quality delivery while influencin...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$73K - $146K *

Unlock potential by leading data project delivery, managing dependencies, and ensuring data quality across healthcare analytics and reporting initiatives. Collaborate with teams to translate business...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$140K - $170K *

Lead the charge in shaping portfolio-level product strategy for P&C insurance technology. Collaborate across multiple product lines to drive data-driven investment decisions and enhance overall portfo...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $160K *

Contribute to the evolution of data-driven healthcare products, shaping strategy and execution. Collaborate with cross-functional teams to deliver AI-enabled solutions that enhance clinical outcomes a...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$130K - $155K *

Manage complex cybersecurity verification programs across large-scale data center projects. Lead coordination among diverse teams, ensuring operational readiness and technical integration throughout c...

United StatesRemote

Reposted 2 days ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$150K - $180K *

Lead the charge in shaping product strategy and execution for a key applications portfolio, driving innovation and growth through AI integration while mentoring a high-performing team in a dynamic hea...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$106K - $177K *

Unlock potential by leading cross-functional teams to shape product strategy, drive growth, and enhance customer value through data-driven insights and innovative solutions across the full product lif...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$121K - $160K *

Advance your career by managing financial operations for project teams, enhancing reporting accuracy, and leading financial analysis to support clinical trials and strategic decision-making...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Unlock the potential of supply chain excellence by leading integrated planning, inventory management, and data analytics. Drive cross-functional collaboration to enhance operational performance and cu...

4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$100K - $130K *

Drive customer success by leading global teams, improving retention, and enhancing product utilization, ensuring a seamless experience across diverse regions and platforms while driving operational ex...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Langan is seeking a Senior Site/Civil Project Manager specializing in Data Centers and Critical Facilities to lead design, permitting, and client management efforts for land development projects. This...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Drive exceptional land development projects in data centers. Lead multi-discipline teams, manage client relationships, and ensure successful project execution from concept through completion, empoweri...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$140K - $200K *

Transform decision-making by leading financial planning and analytics efforts. Oversee reporting, data governance, and deliver actionable insights for stakeholders to drive performance, profitability...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$125K - $150K *

Shape the future of supply chain planning and data analytics by leading integrated processes, optimizing inventory, and driving cross-functional collaboration to enhance operational performance and cu...

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$84K - $142K *

Join a dynamic team to lead project implementations, manage budgets, and drive customer success. Collaborate with cross-functional experts to deliver impactful solutions for federal clients, enhancing...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Grow your career with impactful project management in global health initiatives. Lead diverse teams across 20-25 countries, ensuring effective execution of polio and health security programs while fos...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.