Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Director, Product Management - Infrastructure Automation
$200K - $220K *
Lead product management for an innovative infrastructure automation platform, driving strategy and vision while managing a team of senior product managers. Collaborate cross-functionally to enhance cu...
1 week ago
Production Manager - Topographic Survey and Aerial Imagery
$95K - $115K *
Manage technical standards for topographic survey and data collection, ensuring quality and accuracy in methodologies. Collaborate with project teams to deliver reliable geospatial information for eng...
1 week ago
$110K - $130K *
Shape the future of manufacturing by leading capital projects and automation initiatives. Drive continuous improvement and provide technical guidance to a high-performing team, ensuring successful exe...
Reposted 1 week ago
$160K - $200K *
Join a team that's redefining forensics and collections globally. Lead a skilled team, enhance operational efficiency, and drive client engagement while ensuring compliance and defensibility across re...
2 weeks ago
Senior Director, Growth Initiatives
$260K - $265K *
Innovate the future of hospitality services by unifying existing platforms into a cohesive offering. Collaborate with leadership to define, build, and market a new service model that meets client need...
2 days ago
Vice President (General Contracting)
$150K - $180K *
Pioneer sustainable growth by leading strategic initiatives, strengthening client relationships, and enhancing operational excellence in commercial construction. Drive performance and cultivate top ta...
Reposted 1 week ago
P&C Technical Solutions Architect, Manager
$99K - $232K *
Lead the charge in transforming P&C insurance operations by guiding teams, enhancing service delivery, and implementing technology solutions to streamline processes and improve client engagement acros...
1 week ago
P&C Technical Solutions Architect, Manager
$99K - $232K *
Analyze and enhance service operations in the P&C insurance sector. Lead teams in technology solution design, streamline processes, and mentor staff to improve client engagements and service delivery...
1 week ago
$95K - $115K *
Lead a high-performing project management team, driving operational excellence and customer satisfaction while ensuring efficient project execution and strong stakeholder relationships throughout the...
1 week ago
Director - Technical Product Management, Supply Planning
$152K - $225K *
Develop your career by leading the end-to-end lifecycle of Supply Planning applications. Collaborate with teams to drive product vision, mentor staff, and ensure high-quality delivery while influencin...
1 week ago
$73K - $146K *
Unlock potential by leading data project delivery, managing dependencies, and ensuring data quality across healthcare analytics and reporting initiatives. Collaborate with teams to translate business...
Today
Product Manager, P&C Insurance Technology
$140K - $170K *
Lead the charge in shaping portfolio-level product strategy for P&C insurance technology. Collaborate across multiple product lines to drive data-driven investment decisions and enhance overall portfo...
3 weeks ago
$120K - $160K *
Contribute to the evolution of data-driven healthcare products, shaping strategy and execution. Collaborate with cross-functional teams to deliver AI-enabled solutions that enhance clinical outcomes a...
Reposted today
Senior Technical Program Manager
$130K - $155K *
Manage complex cybersecurity verification programs across large-scale data center projects. Lead coordination among diverse teams, ensuring operational readiness and technical integration throughout c...
Reposted 2 days ago
Director of Product Management, Applications
$150K - $180K *
Lead the charge in shaping product strategy and execution for a key applications portfolio, driving innovation and growth through AI integration while mentoring a high-performing team in a dynamic hea...
2 weeks ago
$106K - $177K *
Unlock potential by leading cross-functional teams to shape product strategy, drive growth, and enhance customer value through data-driven insights and innovative solutions across the full product lif...
3 weeks ago
Sr Manager, Operational Finance
$121K - $160K *
Advance your career by managing financial operations for project teams, enhancing reporting accuracy, and leading financial analysis to support clinical trials and strategic decision-making...
Reposted 1 week ago
$125K - $150K *
Unlock the potential of supply chain excellence by leading integrated planning, inventory management, and data analytics. Drive cross-functional collaboration to enhance operational performance and cu...
4 days ago
$100K - $130K *
Drive customer success by leading global teams, improving retention, and enhancing product utilization, ensuring a seamless experience across diverse regions and platforms while driving operational ex...
Reposted today
Senior Project Manager - Data Center
$110K - $130K *
Langan is seeking a Senior Site/Civil Project Manager specializing in Data Centers and Critical Facilities to lead design, permitting, and client management efforts for land development projects. This...
Reposted 6 days ago
Senior Project Manager - Data Center
$110K - $130K *
Drive exceptional land development projects in data centers. Lead multi-discipline teams, manage client relationships, and ensure successful project execution from concept through completion, empoweri...
Reposted 6 days ago
Senior Manager - Financial Planning and Analysis
$140K - $200K *
Transform decision-making by leading financial planning and analytics efforts. Oversee reporting, data governance, and deliver actionable insights for stakeholders to drive performance, profitability...
Reposted 5 days ago
$125K - $150K *
Shape the future of supply chain planning and data analytics by leading integrated processes, optimizing inventory, and driving cross-functional collaboration to enhance operational performance and cu...
5 days ago
Project Manager - Federal (TS/SCI)
$84K - $142K *
Join a dynamic team to lead project implementations, manage budgets, and drive customer success. Collaborate with cross-functional experts to deliver impactful solutions for federal clients, enhancing...
1 week ago
Project Manager, Polio & GHS Management
$90K - $110K *
Grow your career with impactful project management in global health initiatives. Lead diverse teams across 20-25 countries, ensuring effective execution of polio and health security programs while fos...
2 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.