Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Technical Program Manager, Industrial Controls, R&D
$144K - $211K *
Lead the charge in managing complex Industrial Controls workstreams, ensuring seamless execution of NPI programs. Collaborate across teams to deliver innovative automation solutions on time and within...
Reposted 1 week ago
Project Manager II, dermatology and rheumatology CRO,USA
$95K - $115K *
Champion project success by leading clinical trials from initiation to closure, ensuring compliance with budgets, timelines, and regulations while fostering collaboration among stakeholders and team m...
1 week ago
Project Manager - Cancer Center
$80K - $120K *
Join a team that's driving innovation in cancer research management. This role provides strategic leadership for grant operations, coordinates complex projects, and ensures compliance with institution...
1 week ago
$120K - $145K *
Accelerate the delivery of complex, cross-functional programs by leading strategic planning, governance, and stakeholder engagement to ensure alignment with client objectives and operational excellenc...
5 days ago
Senior AV Project Manager (Systems Integration)
$90K - $110K *
Help us drive project success by managing AV integration projects from inception to completion, ensuring timely delivery, budget adherence, and client satisfaction while fostering collaboration within...
2 weeks ago
Oracle EPM Senior Project Manager
$120K - $145K *
Lead Oracle Cloud EPM projects, ensuring timely delivery and high quality. Collaborate with stakeholders and manage resources to achieve project objectives, fostering team success and effective commun...
Reposted 3 weeks ago
$154K - $258K *
Transform project management excellence by leading the Power Transmission portfolio, ensuring operational alignment, driving financial performance, and fostering talent development across a matrix org...
1 week ago
$100K - $120K *
Unlock your potential as a Project Manager, leading complex, cross-functional projects. Oversee multiple initiatives, ensuring timely delivery and budget adherence while mentoring team members and enh...
3 weeks ago
$110K - $130K *
Drive Agile transformation by leading complex projects, managing dependencies, and fostering collaboration across teams. Empower stakeholders through effective communication and continuous improvement...
1 week ago
$110K - $130K *
Shape the future of education by owning content strategy for assessments. Collaborate with experts and district leaders to enhance quality and drive adoption, leveraging insights to inform product dir...
2 weeks ago
$221K - $260K *
Lead the execution of multi-facility clean energy campuses, overseeing complex solar, wind, and battery projects. Collaborate with diverse teams to ensure operational excellence and strategic alignmen...
3 weeks ago
Director, Supply Chain Planning & Materials
$130K - $176K *
Empower a dynamic team by leading supply chain strategies, enhancing material availability, and optimizing inventory management across multiple sites to meet business goals and customer commitments in...
1 week ago
Director, Michigan Area Manager
$157K - $283K *
Lead the charge in managing transportation infrastructure projects, ensuring quality and efficiency while driving profitability and collaboration across teams to deliver successful outcomes for client...
Reposted 3 days ago
Principal, Technical Program Manager
$130K - $155K *
Join us to lead complex technical programs that enhance delivery predictability and quality. Collaborate with cross-functional teams to drive operational improvements and provide data-driven insights...
Today
Director, Professional Services (Data Migration & Conversion and AI & Automation)
$150K - $180K *
Transform global data migration and AI automation strategies, leading teams to enhance delivery quality and customer value. Drive innovation, operational excellence, and scalable methodologies while f...
4 days ago
$125K - $150K *
Transform enterprise data governance by leading strategy, enhancing quality, and ensuring responsible use. Collaborate with senior leaders to integrate governance into priorities and drive measurable...
4 days ago
Director, Organizational Effectiveness & Culture Transformation
$150K - $180K *
Lead the charge in transforming organizational culture and effectiveness by partnering with senior leaders to embed impactful behaviors and practices. Drive measurable change and foster collaboration...
4 days ago
$110K - $130K *
Join a team that's committed to delivering high-quality project management and engineering services, driving project execution and client satisfaction across various industries while leveraging your e...
Reposted 2 weeks ago
$125K - $150K *
Drive the evolution of a comprehensive Product Security program, overseeing security integration across multiple product offerings. Collaborate with teams to enhance security practices while ensuring...
Yesterday
Senior Manager, Project Controls, Mechanical Estimator, Project & Development Services
$157K - $185K *
Lead project controls initiatives, balancing technical and people leadership. Oversee major programs, mentor teams, and advise clients while contributing to strategic improvements and governance frame...
4 days ago
$88K - $105K *
Lead the charge in managing diverse commercial interiors projects, enhancing client relationships, and driving design excellence. Collaborate with teams to deliver innovative solutions while expanding...
2 weeks ago
Manager/Director, Talent Management
$130K - $170K *
Join a team that's advancing enterprise talent strategy through data-driven performance management, succession planning, and organizational effectiveness, partnering with leaders to build high-perform...
4 weeks ago
Environmental Project Manager, PSG
$80K - $110K *
Lead environmental remediation projects, ensuring safety and compliance while managing teams and client relationships. Oversee proposal preparation, cost estimates, and project execution across variou...
4 days ago
$180K - $210K *
Elevate creative excellence by leading a multidisciplinary team, setting vision and quality standards, and driving impactful brand strategies across diverse channels in a dynamic healthcare environmen...
4 weeks ago
$110K - $130K *
Lead the charge in managing complex public safety projects, ensuring timely delivery and high customer satisfaction. Oversee a diverse portfolio while collaborating with cross-functional teams to driv...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.