Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$192K - $266K *

Drive best-in-class travel support through strategic leadership and operational excellence. Oversee lodging, flights, and customer advocacy, fostering a culture of continuous improvement and exception...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$116K - $159K *

Join a dynamic team to lead ERP projects, enhancing operational efficiencies and driving digital transformation in the Life Sciences sector. Collaborate with stakeholders to ensure seamless integratio...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Empower your career by leading document review projects, optimizing workflows, and enhancing team efficiency. Collaborate with stakeholders to drive best practices and technology integration, ensuring...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Legal & Accounting

$110K - $130K *

Lead cross-functional teams to manage and deliver software implementation projects, enhancing client efficiency and functionality. Collaborate with stakeholders to ensure project success while adherin...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Shape the future of project management by leading software implementations, enhancing efficiency, and collaborating with diverse teams. Drive success through strategic planning and effective communica...

RemoteRemote

1 month ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $110K *

Lead the charge in managing end-to-end ProShop ERP implementations for machine shop clients. Ensure successful adoption through effective project management, client relationship building, and hands-on...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$83K - $104K *

Lead the charge in managing complex client programs, driving operational excellence and strategic direction while fostering strong stakeholder relationships and ensuring exceptional service delivery...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$130K - $176K *

Lead complex water resources projects, integrating technical and commercial strategies while guiding multidisciplinary teams through planning, execution, and client engagement to ensure successful del...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$114K - $155K *

Champion project success by leading medium to large-scale healthcare and technology initiatives, ensuring timely delivery within scope and budget while fostering collaboration among stakeholders and m...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$145K - $188K *

Elevate delivery excellence by shaping strategies for Portfolio Management, ensuring seamless execution across teams while adapting to evolving technologies and processes. Lead the charge in establish...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$98K - $144K *

Deliver project management expertise for multi-million dollar construction initiatives, overseeing renovations, relocations, and facility enhancements while ensuring compliance with corporate standard...

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Champion the management of commercial construction projects from inception to completion. Oversee schedules, budgets, and teams while ensuring quality and client satisfaction. Navigate challenges proa...

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Lead and develop a high-performing project management team, ensuring operational excellence and customer satisfaction while driving regional business performance through effective project execution an...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Shape the future of product development by leading cross-functional teams to deliver innovative solutions from concept to launch, ensuring alignment with business goals and quality standards...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Shape the future of water and wastewater infrastructure by managing complex projects, leading client relations, and mentoring engineering talent while driving innovative solutions in the Central Regio...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$120K - $150K *

Lead complex project management initiatives across multiple channels in the pharmaceutical advertising sector. Oversee cross-functional teams, ensuring timely delivery within budget while mentoring ju...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$66K - $96K *

Join a dynamic team to oversee and manage innovative research studies, ensuring protocol design, project operations, and compliance. Collaborate with experts to drive scientific objectives and enhance...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Champion project delivery by overseeing HV cable testing projects across North America. Ensure alignment with client expectations while managing resources, schedules, and budgets for successful comple...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$80K - $95K *

Manage multiple Corporate Performance Management projects, providing strategic guidance and ensuring timely deliverables. Utilize strong communication and organizational skills to coordinate tasks and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Partner with us to drive financial success in construction projects by managing budgets, forecasts, and reporting. Collaborate with teams to ensure timely completion and profitability while identifyin...

3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$83K - $155K *

Contribute to the success of hygienic sensors by owning product strategy, collaborating with engineering, and driving market insights into actionable requirements. Lead product launches and manage lif...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Partner with us to drive strategic healthcare marketing initiatives. Lead client relationships, oversee peer-to-peer programs, and mentor team members to ensure compliance and achieve results while fo...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Champion enterprise data architecture by establishing standards and a unified data catalog. Collaborate across teams to define metrics and ensure data governance, driving alignment and clarity in a ha...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$108K - $130K *

Transform project delivery by leading multidisciplinary teams in high-stakes engineering design for Mission Critical and Data Center projects, ensuring excellence from concept to construction while me...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead the charge in implementing enterprise software solutions in healthcare, coordinating cross-functional teams to ensure compliance with financial and PCI standards while driving project success and...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.