Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$192K - $226K *

Lead the charge in Clinical Quality Assurance, ensuring compliance and oversight across clinical studies. Drive team growth, develop audit plans, and support continuous improvement while mentoring jun...

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform lives by leading a dedicated team in a residential substance use treatment program, ensuring compliance and quality care while fostering a supportive environment for both staff and patients...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$130K - $160K *

Join a dynamic team to oversee Ambulatory Surgery Centers, driving operational excellence, compliance, and performance improvement while collaborating with clinical leaders to enhance service lines an...

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$185K - $225K *

Join a dynamic team as you drive operational excellence in Medical Affairs. Support strategic initiatives, manage budgets, and enhance processes to ensure compliance and efficiency. Collaborate across...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Optimize analytics workflows in Clinical Operations to enhance productivity and performance insights. Collaborate on data integration, reporting, and automation, ensuring actionable insights drive str...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Partner with us to enhance our analytics workflows, integrating diverse data sources to drive insights for clinical operations leadership. You'll streamline reporting processes, ensuring data quality...

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $140K *

Empower customer success by leading clinical programs and strategic relationships. Drive adoption, optimize workflows, and ensure measurable outcomes while collaborating cross-functionally to enhance...

Today

  •   5 - 7 years exp.  •   Healthcare

$125K - $140K *

Lead the charge in managing strategic clinical programs and customer relationships. Drive adoption, optimize workflows, and ensure account growth while delivering measurable value and fostering collab...

Boston, MARemote

Today

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Join a dynamic team to enhance healthcare analytics by integrating diverse data sources, driving automation, and delivering actionable insights to elevate clinical operations and boost care team perfo...

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $175K *

Drive operational excellence by leading strategic initiatives and managing a team to enhance Care Operations. Transform high-level strategies into scalable systems that improve care delivery and patie...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in managing clinical programs, ensuring operational efficiency and compliance while enhancing patient care quality and satisfaction. Collaborate with staff and stakeholders to foster a...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in enhancing community health through effective management of clinical programs. Oversee operations, ensure compliance, and drive quality care while fostering a supportive environment...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $220K *

Lead the charge in statistical programming, ensuring quality and timelines for clinical development programs. Collaborate with cross-functional teams and oversee regulatory submissions while mentoring...

Today

  •   11 - 15 years exp.  •   Staffing

$182K - $275K *

Drive operational excellence by leading field operations strategy, enhancing efficiency, and aligning cross-functional teams to achieve corporate objectives. Collaborate on incentive compensation and...

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$350K - $430K *

Join a team that's at the forefront of ophthalmic genetic medicine development. Provide strategic oversight for clinical studies, ensuring patient safety and data integrity while collaborating with cr...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$240K - $328K *

Shape the future of medical affairs by developing strategic plans, driving data generation, and fostering key relationships. Collaborate across functions to enhance understanding and communication of...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate agency operations by creating clarity across complex accounts, anticipating risks, and enabling senior communicators to excel. Partner with leadership to build systems that drive exceptional c...

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$72K - $130K *

Drive operational excellence in a 24/7 urgent care setting, leading staff and enhancing patient experiences while ensuring compliance and efficiency. Collaborate with clinical leaders to achieve organ...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$90K - $140K *

Lead the charge in delivering high-quality home care services by providing strategic and operational leadership. Oversee daily operations, financial performance, and staff management while driving exc...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$112K - $223K *

Lead global pharmacovigilance initiatives, ensuring compliance and operational excellence while guiding teams through complex safety reporting challenges across diverse therapeutic areas and trial pha...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$73K - $130K *

Drive the acquisition and usability of clinical data to enhance healthcare outcomes. Collaborate with diverse teams to analyze data gaps, implement integrations, and optimize processes, ensuring timel...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$252K - $283K *

Elevate clinical operations by leading the development of innovative clinical systems. Collaborate with IT and cross-functional teams to enhance trial execution, optimize processes, and leverage techn...

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$90K *

Oversee the coordination of a multicenter clinical trial, managing day-to-day operations while supporting optometry practice functions. Collaborate with sites nationwide to ensure protocol adherence a...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$333K - $416K *

Advance global clinical development efforts for neuropsychiatric disorders, overseeing study design, execution, and interpretation. Build relationships within the medical community and ensure complian...

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$333K - $416K *

Engineer and lead clinical development plans for neuropsychiatric disorders. Drive the execution of clinical studies and foster relationships with key stakeholders while ensuring compliance with regul...

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.