Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$109K - $149K *

Unlock vendor performance by leading analytics and risk adjustment initiatives across healthcare programs. Drive strategy, manage relationships, and ensure accurate reporting to optimize operational s...

Newark, NJRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Empower the growth of in-person behavioral healthcare by leading strategic operations, enhancing provider acquisition, and ensuring compliance. Drive high-impact initiatives while collaborating across...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Accelerate your career by leading CRM product management, shaping the roadmap for Salesforce solutions, and driving innovation in AI integration while collaborating with cross-functional teams to enha...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $190K *

Accelerate customer success by leading post-sales deployments of innovative AI solutions in healthcare. Shape operational strategies to ensure measurable outcomes, adoption, and expansion while drivin...

San Francisco, CARemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$185K - $220K *

Join a team that's redefining engineering service delivery for legal and professional clients. Lead a dynamic organization focused on operational excellence, client satisfaction, and continuous improv...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Business Services

$200K - $250K *

Join a team that's shaping growth strategies for Federal Civilian accounts. Leverage your expertise in federal markets to drive business development, capture opportunities, and enhance customer relati...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's driving innovation in transplant advocacy by integrating business development, marketing, and medical expertise. Collaborate with key stakeholders to enhance KOL engagement and mark...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$175K - $334K *

Drive your career by leading a global team in cybersecurity operations, shaping enterprise-wide strategies for detection and response, and ensuring rapid threat remediation while enhancing operational...

Hartford, CTRemote

Reposted 3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Unlock potential by leading analytics initiatives, transforming data into actionable insights, and mentoring junior analysts. Collaborate with stakeholders to enhance reporting solutions and drive ope...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$99K - $144K *

Transform workforce strategies by leading enterprise-level compensation initiatives. Collaborate across HR and business teams to drive impactful change, utilizing data analysis and project management...

Somerville, MARemote

1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Join a team that's redefining clinical research! As a CRA, you'll build site relationships, ensure compliance, and drive patient recruitment while enjoying world-class training and technology. Experie...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $138K *

Join a dynamic team to drive clinical trial success in Oncology, fostering strong investigator relationships and strategic enrollment strategies. Leverage your expertise to enhance trial execution and...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$240K - $260K *

Elevate collaborative efforts by building and managing executive-level relationships within the Precision Oncology Alliance and leading institutions. This role focuses on strategic partnerships and en...

California, USRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$210K - $250K *

Drive regional growth and performance by overseeing facilities, managing key relationships, and implementing corporate initiatives to ensure high-quality patient care and operational excellence across...

Virginia, USRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $120K *

Champion strategic initiatives to enhance sales development and marketing operations, driving growth through data-driven insights and cross-functional collaboration. Optimize processes and implement s...

California City, CARemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$235K - $270K *

Lead strategic access initiatives and relationships with key stakeholders in managed markets, ensuring alignment and execution of the access strategy for a growing portfolio of therapies. Drive contra...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$130K - $133K *

Advance clinical research by leading site monitoring and management efforts. Ensure compliance with regulatory standards while overseeing study protocols and data integrity. Collaborate with teams to...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$113K - $210K *

Transform patient care by leading a dynamic surgical team, ensuring excellence in operations, compliance, and staff management while enhancing the overall patient experience in a fast-paced environmen...

Seattle, WARemote

6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Shape complex, cross-functional programs that drive enterprise transformation, focusing on Customer Data Platform implementation and AI initiatives. Collaborate with diverse teams to ensure strategic...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $112K *

Transform legal operations by streamlining processes, enhancing data management, and implementing innovative technology solutions. Collaborate cross-functionally to optimize workflows and support a sc...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Accelerate regional commercialization of innovative cell therapies by leading strategic initiatives, enhancing customer engagement, and ensuring optimal patient access while collaborating cross-functi...

Florida, NYRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$144K - $195K *

Oversee value-driven strategies for obesity coverage, enhancing payer access through robust communication and market analysis, while leading cross-functional partnerships and research to optimize cove...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $195K *

Lead the strategy and execution of commercial drug product manufacturing, ensuring operational performance and supply security while collaborating across teams to develop effective manufacturing plans...

San Diego, CARemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Elevate scientific communication at a leading biotech firm by building Medical Information and Review capabilities. Drive quality and integrity in medical content while collaborating across teams to s...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Champion regulatory strategy and lead insurance affairs, engaging with regulators and advising clients on AI and imagery use. Build a robust filing program and ensure compliance while shaping industry...

Lehi, UTRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.