Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$154K - $242K *

Take ownership of regulatory compliance for promotional materials in the pharmaceutical sector. Leverage your expertise to guide cross-functional teams, mentor staff, and ensure adherence to FDA regul...

Massachusetts, USRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Shape the future of enrichment programs by driving strategy, execution, and operational excellence across multiple sites, ensuring impactful experiences for families and children while achieving finan...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$155K - $192K *

Lead the charge in transforming member acquisition strategies through data-driven insights, optimizing marketing performance, and driving sustainable growth in a fully remote environment. Collaborate...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$138K - $170K *

Lead the charge in ensuring client success through effective onboarding, continuous engagement, and maximizing value realization on the analytics platform. Leverage strong relationship management and...

Dallas, TXRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$100K - $122K *

Unlock your potential as you lead financial planning, analytics, and strategic initiatives. Collaborate closely with executives to drive performance improvements and optimize resource allocation, fost...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $100K *

Support the CEO Office as an Executive Assistant, facilitating smooth operations, managing schedules, and coordinating high-level events. Drive strategic initiatives and foster collaboration among pee...

California, USRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead a talented design team to shape the user experience across multiple platforms. Define interaction patterns, elevate design standards, and collaborate with cross-functional teams to deliver innova...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Elevate operational excellence by leading claims operations, ensuring compliance and efficiency while driving process improvements and team development. Collaborate across functions to meet client com...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Join a dynamic team as a Sales Director, leading sales initiatives, enhancing physician partnerships, and driving business growth through strategic leadership and high-performance coaching...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $150K *

Join a team that's shaping the future of healthcare by leading M&A integration efforts. Drive strategic initiatives, manage high-stakes projects, and collaborate with senior leadership to enhance grow...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$190K - $214K *

Champion HCP engagement by leading personal promotion strategies and speaker programs. Collaborate cross-functionally to develop compliant promotional tools that enhance brand objectives and optimize...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$247K - $337K *

Lead CMC Pharmaceutical Development for small molecules, driving innovation and strategy from early development to commercialization while ensuring regulatory compliance and operational excellence...

New Jersey, USRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Develop and optimize complex applications while collaborating with stakeholders and supporting junior staff to enhance workflow, usability, and system functionality in healthcare settings. Engage in t...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $200K *

Join a dynamic team to design and implement secure EHR integrations, enhancing healthcare interoperability. Lead the integration of SMART on FHIR applications into clinical workflows while establishin...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$128K - $160K *

Transform patient care by leading pharmacy programs, enhancing operations, and fostering partnerships. Drive compliance and quality while mentoring a high-performing team to deliver exceptional servic...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$114K - $171K *

Join a team that's driving growth in clinical trials by identifying and securing partnerships. Collaborate with cross-functional leaders to enhance visibility and expand opportunities, ensuring seamle...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Shape the future of legal operations by leading a dynamic team focused on automation and technology. Drive efficiency in contract management and vendor relationships while defining metrics that enhanc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Join a team that's dedicated to ensuring the quality and safety of clinical trials. As a Senior Clinical Research Associate, you'll manage site relationships, oversee monitoring activities, and contri...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$143K - $179K *

Shape and lead client implementations for a cutting-edge trading platform, guiding asset and wealth managers through system configuration and go-live processes while ensuring client satisfaction and p...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$215K - $230K *

Join a team that's shaping the future of hematology-oncology by serving as a Senior Medical Science Liaison. You'll build scientific relationships, provide insights, and support the launch of innovati...

Chicago, ILRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$215K - $230K *

Join a team that's shaping the future of hematology-oncology by serving as a Senior Medical Science Liaison. Build scientific relationships, provide insights, and support the launch of innovative ther...

San Diego, CARemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$215K - $230K *

Join us to empower the hematology-oncology community as a Senior Medical Science Liaison. Build scientific relationships, share insights, and support the launch of innovative therapies for cutaneous T...

Las Vegas, NVRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Transform Maven's go-to-market narrative by defining and evolving cohesive messaging that resonates with employers, clients, and members. Collaborate across teams to ensure strategic alignment and imp...

New York, NYRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Champion a transformative product vision, leading cross-functional teams to drive strategic outcomes in a dynamic digital health environment. Shape the future of patient care and client experience whi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $110K *

Drive business growth by identifying and qualifying federal procurement opportunities, focusing on healthcare contracts. Collaborate on capture strategies and build partnerships to enhance win probabi...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.