Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$150K - $195K *

Champion the future of clinical science by leading trial design, data analysis, and cross-functional collaboration to ensure compliance with GCP and drive innovative solutions in rare disease research...

San Diego, CARemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $130K *

Lead the charge in clinical trial monitoring, ensuring compliance and quality through oversight, guidance, and collaboration with cross-functional teams to enhance site performance and study execution...

Boston, MARemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$115K - $135K *

Shape the future of clinical trials by leading site monitoring efforts, ensuring compliance, and fostering collaboration across teams. Drive quality and efficiency in trial execution while mentoring j...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $130K *

Elevate clinical trial success by overseeing site monitoring, ensuring compliance, and providing leadership. Collaborate with cross-functional teams to address site issues, enhance recruitment, and ma...

Boston, MARemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $130K *

Accelerate clinical trial success by leading site monitoring efforts, ensuring compliance, and providing expert guidance to the CRA team. Collaborate cross-functionally to resolve issues and enhance s...

Boston, MARemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead clinical trial monitoring efforts, ensuring compliance and quality. Collaborate with cross-functional teams to address site issues, manage budgets, and provide oversight. Drive successful study e...

Boston, MARemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$280K - $300K *

Shape the future of clinical supply management by leading strategy and execution for transformative therapies. Collaborate cross-functionally to ensure timely delivery of investigational products, whi...

Boston, MARemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $200K *

The Senior Consultant - Clinical Operations will lead the implementation of Clinical Operations applications to enhance efficiency in Clinical Trials for life sciences clients. This role involves mana...

Madison, WIRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$223K - $313K *

Elevate healthcare outcomes by leading clinical determinations and authorizations. Utilize your medical expertise to ensure compliance with national guidelines while collaborating with diverse teams i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Drive quality excellence in clinical programs by overseeing compliance, risk management, and vendor oversight. Collaborate cross-functionally to ensure adherence to GCP regulations and lead inspection...

San Francisco, CARemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$138K - $231K *

Lead revenue cycle operations for a multi-site Center of Excellence, driving performance improvements, managing budgets, and mentoring teams to enhance billing accuracy and cash collections while ensu...

Texas, USRemote

6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Unlock operational excellence by leading multi-site Ambulatory Surgery Centers. Drive growth strategies, optimize performance, and foster strong partnerships with physician leaders while managing sign...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$122K - $177K *

Unlock potential by leading HRIS strategy and optimization, overseeing a team to enhance Workday and UKG systems. Drive transformation and collaboration across HR, Finance, and Operations for impactfu...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Help us drive business development in oncology by leading strategic partnerships and optimizing resources to enhance clinical outcomes and market potential for our innovative diagnostic and therapeuti...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join us to lead a dynamic team in optimizing revenue cycle operations for multiple clients. Drive continuous improvement and ensure client satisfaction while managing performance metrics and fostering...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$130K - $150K *

Drive operational excellence by overseeing day-to-day functions and enhancing processes to ensure high-quality deliverables. Collaborate across teams to boost performance and elevate patient satisfact...

Columbia, MDRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$203K - $304K *

Champion innovative operational strategies in clinical research, driving excellence in bid defense meetings and proposal development. Collaborate with cross-functional teams to enhance study execution...

United StatesRemote

1 week ago

  •   15+ years exp.  •   Healthcare

$160K - $200K *

Drive strategic growth and business development for National Accounts in Urology and Oncology, optimizing resources and leading negotiations to enhance healthcare outcomes through innovative diagnosti...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Lead the charge in optimizing top-of-funnel marketing operations, driving measurable pipeline growth through strategic planning, data governance, and team leadership. Collaborate with cross-functional...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$298K - $340K *

Join a dynamic team to lead strategic statistical programming initiatives, ensuring top-quality deliverables and compliance across diverse clinical trials. Collaborate with cross-functional partners t...

United StatesRemote

Reposted 3 weeks ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$134K - $267K *

Champion clinical excellence by providing medical oversight and leadership in global research. Collaborate with cross-functional teams to ensure participant safety and drive successful clinical outcom...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$161K - $210K *

Elevate workforce management by leading recruitment, onboarding, and performance strategies. Drive clinician readiness and productivity while ensuring quality care through data-driven decision-making...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $195K *

Innovate member experience strategies by translating enterprise goals into actionable plans. Drive performance improvements in CAHPS and HOS programs through provider engagement and data analysis, ens...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$242K - $282K *

Lead the oversight of contractual matters across departments, serving as a trusted advisor to internal stakeholders from pre-clinical to commercial readiness. This role emphasizes collaboration and ex...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Join a dynamic team to optimize supply chain operations, ensuring efficient medication delivery from pharmacy partners to patients. Oversee systems, processes, and a team to scale operations amidst ra...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.