Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$150K - $180K *

Join a team that's dedicated to enhancing patient access through strategic design and management of support programs. Oversee vendor relationships and ensure compliance while driving initiatives that...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$162K - $243K *

Join a team that's dedicated to advancing clinical trials through strategic oversight and collaboration. Lead project management efforts globally, ensuring quality, cost, and timeline objectives are m...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by leading clinical reimbursement strategies across skilled nursing facilities, ensuring compliance and optimal performance through collaboration with multidisciplinary teams to enhan...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$60K - $132K *

Champion operational excellence by coordinating teams to enhance efficiency, manage resources, and drive process improvements. Collaborate across functions to meet business objectives and foster a cul...

Texas, USRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$54K - $119K *

Lead the charge in optimizing operational efficiency by coordinating cross-functional teams, managing resources, and driving process improvements to enhance service delivery and achieve business objec...

Kentucky, USRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$165K - $180K *

Oversee and optimize US regional clinical trials, ensuring execution and compliance. Collaborate with cross-functional teams and manage vendor relationships while driving process improvements in a fas...

Houston, TXRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Partner with us to enhance cardiology practices in the Detroit area, driving operational excellence and financial performance while leading a dedicated team to optimize patient care and market presenc...

Denver, CORemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Transform service delivery by leading high-performance teams, ensuring client satisfaction, and driving strategic initiatives. Collaborate across departments to enhance practice management and achieve...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$245K - $286K *

Elevate clinical quality assurance through strategic leadership and oversight of global trials, ensuring compliance with GCP regulations. Drive quality culture and inspection readiness while mentoring...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in optimizing clinical supply chain strategies, ensuring seamless material availability for global trials. Collaborate with cross-functional teams to enhance operational efficiency and...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $140K *

Lead the charge in managing strategic clinical programs and customer relationships. Drive adoption, optimize workflows, and ensure account growth while delivering measurable value and fostering collab...

Boston, MARemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $175K *

Drive operational excellence by leading strategic initiatives and managing a team to enhance Care Operations. Transform high-level strategies into scalable systems that improve care delivery and patie...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$350K - $430K *

Join a team that's at the forefront of ophthalmic genetic medicine development. Provide strategic oversight for clinical studies, ensuring patient safety and data integrity while collaborating with cr...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$140K - $170K *

Join a dynamic team to optimize operational systems, drive growth, and enhance performance across departments. Collaborate with leadership to ensure strategic goals translate into measurable results a...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$112K - $223K *

Lead global pharmacovigilance initiatives, ensuring compliance and operational excellence while guiding teams through complex safety reporting challenges across diverse therapeutic areas and trial pha...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$73K - $130K *

Drive the acquisition and usability of clinical data to enhance healthcare outcomes. Collaborate with diverse teams to analyze data gaps, implement integrations, and optimize processes, ensuring timel...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$89K - $148K *

Drive your career with impactful consulting in healthcare, enhancing operational efficiency and financial performance for provider organizations through data analysis and project management...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$140K - $150K *

Shape your career by managing clinical research studies, ensuring compliance with regulations, and leading cross-functional teams to achieve project milestones efficiently and effectively...

Boston, MARemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K *

Optimize revenue cycle management by leading a dynamic team to enhance processes, drive automation, and ensure compliance in a fast-paced telehealth environment. Collaborate with cross-functional team...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$180K - $220K *

Join a team that's shaping clinical sales strategies and enhancing client relationships. Lead initiatives that drive market growth and improve patient satisfaction while collaborating across disciplin...

Harrisburg, PARemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$156K - $261K *

Shape the future of compliance operations by leading SOX testing, software asset management, and compliance consulting. Drive operational efficiency and continuous improvement while managing budgets a...

Philadelphia, PARemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$144K - $160K *

Champion operational excellence by leading teams to enhance efficiency and care delivery. Drive AI integration, manage P&L, and collaborate cross-functionally to support growth and sustainability in h...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$190K - $260K *

Transform client delivery in biotech by leading a high-performing team, driving operational excellence, and fostering innovation. Champion technology adoption and continuous improvement to enhance cli...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$207K - $346K *

Lead the charge in evidence-based medical case reviews to ensure high-quality patient care while collaborating with a network of over 500 physician colleagues in a fully remote environment...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$225K - $281K *

Join a team that's pushing the boundaries of oncology research! This key role involves designing and leading clinical trials, ensuring data integrity, and collaborating with global experts to advance...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.