Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$120K - $150K *

Lead the charge in elevating client success through strategic relationship management, team development, and robust operational frameworks to ensure exceptional service delivery and client satisfactio...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$255K - $310K *

Lead a high-performing team to execute market access strategies, optimize payer engagement, and enhance product positioning. Drive collaboration across stakeholders to ensure effective reimbursement a...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$247K - $309K *

Unlock potential by leading medical strategy for hematologic malignancies. Collaborate cross-functionally to drive evidence generation, stakeholder engagement, and launch readiness, ensuring impactful...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive operational excellence at a leading healthcare organization by leading funded medical accounts receivable. Build a high-performing collections team, enhance cash flow, and ensure compliance whil...

Pennsylvania, USRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$69K - $101K *

Lead the charge in holistic clinical care management, enhancing health outcomes through comprehensive assessments, care planning, and coordination for diverse member populations with complex needs...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a dynamic team to lead the creation of impactful scientific content, enhancing medical education and patient outcomes. Collaborate cross-functionally, mentor writers, and drive excellence in heal...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$163K - $297K *

Champion the development and execution of innovative digital product strategies across EMEA, enhancing consumer experiences and driving key performance indicators in a high-growth e-commerce environme...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Drive strategic growth and retention by managing high-value enterprise accounts, fostering executive relationships, and leading contract negotiations to align client objectives with innovative solutio...

Minneapolis, MNRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Transform the landscape of emerging therapies by leading strategic clinical innovation, guiding development, and ensuring regulatory readiness for novel therapeutic solutions across early- and mid-sta...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $150K *

Champion effective publication strategies and lead scientific communication initiatives, acting as a strategic partner to clients and teams. Navigate complex medical affairs content to drive impactful...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Drive impactful HR strategies in a dynamic global environment, collaborating with senior leaders to align people initiatives with business goals. Contribute to a newly forming team focused on growth a...

Cambridge, MARemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$275K - $350K *

Lead the charge in transforming operations by integrating AI and technology to enhance member and clinician experiences, ensuring efficient care delivery and operational excellence across a distribute...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $206K *

Transform the accounting landscape by leading strategic initiatives that enhance operational efficiency, standardize processes, and drive technology integration, all while ensuring public company read...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$165K - $175K *

Drive operational excellence by leading multi-state revenue cycle management, optimizing physician billing, and enhancing payer relationships. Collaborate with stakeholders to maximize collections and...

Pennsylvania, USRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$155K - $171K *

Lead transformative consulting projects by conducting in-depth research and presenting strategic recommendations. Collaborate with clients and junior team members to drive high-quality deliverables an...

Chicago, ILRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$232K - $348K *

Lead the charge in oncology pharmacology, managing scientific teams to drive drug discovery from early stages through regulatory approval while ensuring alignment across cross-functional teams...

RemoteRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$170K - $195K *

Lead and inspire a remote team of neuropsychologists, ensuring high-quality, client-centered care while promoting clinical excellence and compliance in a collaborative environment. Drive operational e...

Lynbrook, NYRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by leading product strategy for patient recruitment, enhancing engagement and operational efficiency. Collaborate with cross-functional teams to drive measurable outcomes and improve...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Shape operational excellence by driving performance improvements through data-driven strategies. Collaborate with leadership to enhance efficiency, growth, and care delivery, ensuring sustainable resu...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Elevate clinical trial management by leading Phase I-IV studies, ensuring timely, budget-compliant delivery while developing staff and enhancing processes. Collaborate with teams to meet sponsor expec...

Covington, KYRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$134K - $249K *

Champion pharmacy excellence by leading strategic initiatives and operational oversight for a pharmacy benefit management program. Drive quality, compliance, and innovation while collaborating with cr...

Indiana, USRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $195K *

Drive change management initiatives that enhance employee engagement and operational efficiency. Collaborate across teams to ensure successful adoption of technology and policy changes, while providin...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$165K - $215K *

Shape the future of value-based payments by leading product strategy, overseeing team development, and driving market innovations within a collaborative, cross-functional environment...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$200K - $240K *

Unlock potential by leading high-quality, evidence-based substance use disorder treatment as a physician leader. Collaborate with cross-functional teams to shape clinical governance and enhance servic...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Shape the future of healthcare technology by leading product management efforts. Drive innovation and strategy while mentoring a team to enhance software solutions that improve patient outcomes and op...

Georgia, USRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.