Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$150K - $180K *

Transform the clinical sales landscape by leading a regional team to drive utilization growth, enhance patient treatment metrics, and foster cross-functional collaboration for commercial success in in...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$121K - $176K *

Transform operational excellence by leading a team to implement Lean strategies, drive continuous improvement initiatives, and enhance safety, quality, and cost performance across multiple sites while...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$104K - $143K *

Contribute to strategic clinical operations initiatives that enhance efficiency and standardize workflows. Collaborate across teams to support enterprise readiness and successful program implementatio...

Kentucky, USRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$104K - $143K *

Unlock your potential by leading strategic initiatives that drive measurable business results. Collaborate with senior leaders to solve complex problems, evaluate opportunities, and translate strategy...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in optimizing marketing operations to drive developer adoption, pipeline growth, and revenue. Oversee systems, processes, and insights while collaborating with cross-functional teams t...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$215K - $408K *

Lead the charge in medical management and quality improvement initiatives, ensuring optimal care delivery and cost-effectiveness. Collaborate with clinical teams to enhance utilization management and...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $190K *

Transform regulatory affairs by leading strategic initiatives in advertising, promotion, and labelling for global products. Drive compliance and innovation while collaborating with cross-functional te...

New Jersey, USRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Partner with us to drive strategic healthcare marketing initiatives. Lead client relationships, oversee peer-to-peer programs, and mentor team members to ensure compliance and achieve results while fo...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$69K - $101K *

Join us to enhance member health outcomes through holistic care management, collaborating with multidisciplinary teams to support individuals with complex needs. Utilize assessments and interventions...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

Champion the execution of a comprehensive medical affairs plan for renal cancer theranostics, driving cross-functional alignment and strategic initiatives to enhance patient outcomes and advance clini...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$138K - $201K *

Transform provider analytics by leading data-driven insights for contracting, performance, and network strategy. Collaborate with cross-functional teams to enhance network adequacy and drive strategic...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$200K - $235K *

Drive product excellence by owning the lifecycle and security of high-performance client SaaS platforms hosted on AWS. Lead a dedicated team to optimize operations, ensure compliance, and deliver seam...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$183K - $229K *

Drive operational excellence as a senior leader, overseeing market performance, managing physician and payer partnerships, and executing strategic plans to achieve financial and clinical targets in a...

Ohio, USRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$259K - $300K *

Engage in comprehensive psychiatric care and leadership within Certified Community Behavioral Health Clinics, providing assessments, medication management, and collaboration with staff to enhance trea...

Brooklyn, NYRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$134K - $249K *

Transform provider engagement strategies to enhance performance and quality across multiple business lines. Lead initiatives that optimize relationships, reduce costs, and align with organizational go...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$199K - $321K *

Join a dynamic team to provide strategic legal counsel on diagnostics and medical devices, ensuring compliance with FDA regulations and commercial strategies while collaborating across business units...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$76K - $110K *

Lead operational excellence in Medical and Clinical Affairs, managing grants, coordinating cross-functional teams, and ensuring efficient program execution to enhance healthcare outcomes and support s...

Woburn, MARemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Drive the execution of a comprehensive medical affairs plan for prostate cancer theranostics, collaborating across functions to enhance strategy, launch readiness, and lifecycle planning while advanci...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Empower your career by driving project delivery and managing Agile teams. Utilize AI tools to enhance decision-making, anticipate risks, and ensure timely outcomes. Collaborate with stakeholders to ma...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$202K - $304K *

Shape operational strategies for complex clinical studies globally, collaborating with cross-functional teams to enhance proposal development, budget creation, and client engagement, while mentoring c...

United StatesRemote

1 week ago

  •   15+ years exp.  •   Healthcare

$160K - $180K *

Drive the transformation of HR operations by leading UKG Pro implementation, optimizing processes, and enhancing analytics capabilities across a multi-state environment, ensuring seamless employee lif...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in developing and overseeing scientific content across multiple therapeutic areas, ensuring high-quality contributions and strategic client interactions to drive growth and innovation...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$149K - $298K *

Lead strategic and operational initiatives for field clinical teams, ensuring compliance and effective trial support for TMVR programs while driving positive patient outcomes and team performance...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$143K - $193K *

Transform clinical operations by leading regional study delivery, ensuring quality and compliance while managing timelines and budgets. Collaborate with cross-functional teams to drive study success a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$215K - $235K *

Pioneer comprehensive commercial operations by designing, implementing, and optimizing pricing and deal negotiation processes. Drive ongoing analytics and continuous improvement, ensuring success in a...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.