Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Associate Director Precision Medicine - Clinical Diagnostics
$176K - $287K *
Contribute to companion diagnostic strategy and development, leading programs from biomarker feasibility to clinical validation. Collaborate across teams to ensure diagnostics align with therapeutic m...
2 weeks ago
Assoc Dir, Neuro Thought Leader Liaison (West region)
$190K - $225K *
Empower commercial strategies by building relationships with key thought leaders in rare neurological diseases, capturing insights to inform brand development and launch planning, and ensuring impactf...
Reposted 2 days ago
Associate Director, Enterprise Information Architecture
$143K - $193K *
Accelerate progress at the forefront of data-driven transformation in life sciences. Collaborate with leadership to shape and execute enterprise data architecture initiatives, ensuring scalable, trust...
2 weeks ago
Complex Claim Specialist, Excess & Surplus
$125K - $155K *
Analyze complex commercial claims, ensuring thorough investigations and effective resolutions. Collaborate with internal and external parties to manage litigated and non-litigated claims, leveraging s...
3 weeks ago
Clinical Account Executive Hereditary Cancer - PNW
$105K - $130K *
Unlock potential by driving sales growth in a defined territory through strategic relationship management and promotion of genetic diagnostic testing services to healthcare professionals and instituti...
Today
Senior Director, Regulatory CMC (remote)
$175K - $283K *
Champion regulatory excellence by leading CMC strategies for small molecule programs, ensuring compliance and driving successful submissions from early development through commercialization in a dynam...
5 days ago
$164K - $305K *
Lead the charge in developing strategic relationships with C-suite executives to drive growth, retention, and value realization across complex health systems, ensuring integrated solutions and measura...
1 week ago
Senior Quality Operations Specialist, Audit
$74K - $98K *
Champion regulatory audit excellence by leading PACE audits, ensuring compliance, and driving cross-functional collaboration to enhance operational readiness and continuous improvement across the orga...
3 weeks ago
Senior Product Manager, Enterprise Solutions
$174K - $218K *
Reimagine healthcare by shaping partnerships that drive innovative virtual-first care solutions. As a Senior Product Manager, you will bridge product and commercial teams, enhancing member engagement...
Reposted 4 weeks ago
Remote Quality Improvement Data Analyst
$70K - $106K *
Transform operational data into actionable insights while collaborating with cross-functional teams to support business decisions and enhance efficiency. Leverage analytical skills to drive performanc...
Reposted 3 days ago
$120K - $145K *
Join a team that's transforming medicine by engaging with KOLs and healthcare professionals. Leverage your clinical expertise to communicate product benefits, support education, and drive strategic in...
Reposted 5 days ago
Director, Clinical Quality Assurance
$195K - $256K *
Elevate clinical quality assurance by designing and executing strategies for compliance, audit management, and oversight of global clinical operations. Collaborate with stakeholders to ensure adherenc...
1 week ago
Senior Revenue Accountant (Virtual/Remote)
$100K - $115K *
Optimize revenue accounting and billing operations for a rapidly growing SaaS organization. Collaborate with leadership on process improvements, ASC 606 compliance, and support integration initiatives...
Reposted yesterday
$135K - $160K *
Help us shape the future of pulmonary care by leveraging your clinical expertise to drive product development, enhance workflows, and ensure effective solutions for COPD, asthma, and other pulmonary c...
1 week ago
Regional Software Sales Executive
$110K - $130K *
Innovate and drive sales success by leading complex solutions for enterprise clients. Leverage your expertise in P2P software to identify opportunities, engage stakeholders, and implement strategic sa...
Reposted 3 weeks ago
Enterprise Account Executive-Midwest
$119K - $155K *
Shape the future of enterprise sales by driving growth and cultivating long-term relationships. Manage complex sales cycles and leverage AI tools to optimize efficiency and insights, ensuring customer...
Reposted 3 weeks ago
$90K - $140K *
Transform the commissioning process by leading design reviews, functional testing, and site visits. Collaborate with teams to ensure project success and compliance, while managing documentation and tr...
2 weeks ago
Commercial Physical Damage Field Adjuster
$75K - $129K *
Empower clients by expertly assessing commercial damage claims, negotiating settlements, and delivering exceptional service in diverse environments. Join a dynamic team dedicated to providing top-notc...
1 week ago
Sr. Program Intelligence & Performance Management Consultant
$115K - $163K *
Drive impactful performance insights by defining and managing the measurement framework for ancillary product portfolios, ensuring strategic alignment and regulatory compliance while advising leadersh...
3 weeks ago
RN - Full Time Days - SF Village
$70K - $99K *
Provide individualized nursing care by utilizing the nursing process to assess, plan, implement, and evaluate care for residents. Collaborate with interdisciplinary teams to ensure comprehensive healt...
3 weeks ago
Senior Manager, GEO Strategy & AI Search Activation
$64K - $162K *
Drive innovative strategies to enhance visibility across Generative Engine Optimization and AI search platforms, supporting higher education clients and professional education products through data-dr...
3 weeks ago
$136K - $160K *
Elevate operations through AI-driven automation to enhance incident management, streamline ticket resolution, and optimize service health with self-healing observability, all while collaborating acros...
Reposted 2 weeks ago
$250K - $300K *
Grow your career with a dynamic role leading customer acquisition in GenAI Safety Services. Own the full sales cycle, engage with senior stakeholders, and position strategic AI solutions to drive impa...
3 weeks ago
$110K - $130K *
Join a dynamic team as a SOC Engineer, where you'll onboard customers into managed security services, configure Microsoft security tools, and ensure reliable telemetry across diverse environments, all...
2 weeks ago
$135K - $160K *
Join a team that's redefining data architecture by leading innovative modeling and integration initiatives. Collaborate with AI Engineers to create scalable datasets and optimize performance in a mult...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.