Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Manager, Patient Services Promotions
$138K - $183K *
Lead the development and execution of patient support strategies to enhance access and engagement for oncology therapies, collaborating cross-functionally to optimize promotional initiatives and drive...
1 week ago
Advanced Practice Provider (NP or PA): Palliative Care
$120K - $155K *
Empower patients by delivering compassionate, patient-centered palliative care through virtual consultations. Collaborate with a dynamic team to enhance quality of life for members with complex needs...
3 weeks ago
Regional Sales Director - Knoxville
$180K - $215K *
Elevate regional sales performance by leading a high-performing team, executing launch strategies, and fostering customer relationships in a dynamic environment. Drive accountability and collaboration...
1 week ago
Assistant Director, Student Experience and Operations
$90K *
Advance student success by leading strategic initiatives across the student lifecycle. Collaborate with teams to enhance operational efficiency, optimize technology, and improve student satisfaction t...
1 week ago
$220K - $260K *
Transform your career by leading product strategy and execution for payment solutions. Drive innovation in payment workflows, enhance reliability, and optimize operational efficiency while collaborati...
2 weeks ago
Strategic Account Executive- Inventory Services
$94K - $125K *
Empower your career with an impactful role driving sales of complex supply chain solutions in healthcare. Engage C-suite executives, manage strategic accounts, and address industry challenges to deliv...
Reposted 4 weeks ago
$215K - $230K *
Transform compliance into actionable insights by bridging technical teams and auditors. Own your area of responsibility, enhance security measures, and drive automation in a multi-cloud environment wh...
1 week ago
Assistant General Counsel - Managed Services Organization
$150K - $235K *
Elevate your legal career by delivering strategic counsel and effective services to Managed Services Organizations and physician practices, while managing complex legal projects and mentoring a team i...
2 weeks ago
$150K - $180K *
Lead the charge in enhancing engineering security for our SaaS platform. Collaborate with teams to identify risks, improve practices, and implement automation, ensuring secure development and robust v...
Yesterday
Staff Psychiatrist (MD or DO) - Remote | Telehealth | Full-Time or Part-Time | South Dakota
$300K - $500K *
Join a pioneering team of psychiatrists providing patient-centered care via telehealth. Enjoy flexibility and autonomy while being supported by a robust administrative infrastructure, allowing you to...
Reposted 4 weeks ago
$130K - $150K *
Lead the charge in driving impactful cybersecurity and AI risk programs, managing multidisciplinary teams, and translating complex findings into executive insights while fostering client relationships...
4 weeks ago
$188K - $245K *
Drive innovative UX design strategies in clinical settings, leading a talented team to enhance decision support and care coordination. Collaborate across functions to integrate AI and elevate user exp...
4 weeks ago
Clinical Scientist - Oncology - Home-based anywhere in the US - FSP
$110K - $130K *
Elevate your career by supporting clinical studies through scientific expertise, operational delivery, and compliance. Collaborate with cross-functional teams and stakeholders to ensure successful tri...
3 weeks ago
Senior Software Security Architect
$135K - $160K *
Advance security integration by leading DevSecOps initiatives, enhancing software delivery, and establishing robust security standards across engineering teams to mitigate risks and improve efficiency...
Yesterday
$160K - $180K *
Join a team that's driving growth in Life Sciences by managing key client relationships and delivering innovative solutions. You'll oversee the entire sales process, collaborating with experts to achi...
4 weeks ago
$77K - $121K *
Unlock your potential as you lead organic social strategy, engage millions, and shape brand voice across platforms. Collaborate with creative teams to drive impactful content and community engagement...
Today
Sr. DataOps Engineer, Data Platform
$130K - $160K *
Transform data operations by leading our Snowflake platform migration, ensuring security, reliability, and cost efficiency while collaborating across teams to standardize practices and enhance data ma...
3 days ago
Account Manager, Life Science, Public Health Labs (East Coast)
$105K - $120K *
Engage with public health labs to enhance customer satisfaction and drive sales. Collaborate with cross-functional teams to execute market strategies and foster relationships with key opinion leaders...
Yesterday
Key Account Manager - Dallas, TX
$170K - $205K *
Transform sales strategies by driving key account growth, building relationships, and executing plans for a new kidney transplant product. Collaborate cross-functionally to ensure optimal market acces...
3 weeks ago
Technical Architect – Appian & Salesforce Platforms
$172K - $210K *
Architect and lead customer-focused application development initiatives, translating business needs into robust software solutions. Leverage modern technologies and AI tools to ensure high-quality, se...
1 week ago
Sr. Staff Engineer (Fullstack/Frontend)
$150K - $180K *
Lead the charge in architectural innovation and technical strategy across systems. Shape long-term solutions, drive frontend performance, and foster cross-functional collaboration to enhance user expe...
Reposted 4 weeks ago
$125K - $150K *
Engage with a talented team to drive growth and innovation in pharma sales. Own the sales cycle from strategic prospecting to closing high-impact deals, while developing key relationships that enhance...
Reposted 3 weeks ago
General Liability Claim Representative
$90K - $110K *
Champion the management of complex liability claims, ensuring thorough investigations, negotiations, and settlements. Collaborate with internal and external stakeholders to maintain high standards of...
1 week ago
Associate Director, Client Media Solutions
$95K - $120K *
Accelerate progress at the intersection of media and healthcare by leading integrated planning and strategy for pharmaceutical clients. Drive impactful engagement initiatives while mentoring a talente...
1 week ago
Clinical Sales Specialist, Pulmonary
$110K - $130K *
Unlock your potential by driving sales of innovative pulmonary solutions. Collaborate with diverse stakeholders to enhance patient care and achieve sales targets in a dynamic healthcare environment. J...
Reposted 4 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.