Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

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$118K - $142K *

Engage in comprehensive site monitoring and management for clinical trials, ensuring adherence to protocols and regulatory standards while providing high-quality care and support to study participants...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$62K - $127K *

Join a team that's dedicated to delivering exceptional customer service while managing complex general liability claims. Collaborate with legal partners to develop strategies for effective resolution...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$135K - $160K *

Elevate your career by building transformative backend services and distributed systems that empower enterprises to monitor AI effectively. Drive projects from vague concepts to deployed products whil...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$246K - $332K *

Shape the future of health economics and outcomes research by leading strategic initiatives across the nephrology portfolio, ensuring high-quality evidence generation and collaboration with cross-func...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $90K *

Join a team that's transforming customer onboarding by leading complex implementations, aligning stakeholders, and delivering scalable solutions that drive success and revenue. Your expertise will bri...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$193K - $262K *

Lead and optimize field effectiveness initiatives, driving sales performance through insights and operational excellence. Manage a high-performing team while collaborating cross-functionally to enhanc...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$189K - $246K *

Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Accelerate growth at a leading cyber security provider by driving enterprise sales. Utilize your strategic selling skills and build key relationships with C-level execs to implement innovative solutio...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$230K - $270K *

Shape the future of compliance technology by leading the design and implementation of data-driven solutions that meet global regulatory standards, ensuring operational efficiency and effectiveness acr...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Innovate with us to drive strategic product marketing initiatives that enhance capital equipment and consumable sales. Lead go-to-market strategies and foster market adoption, ensuring alignment with...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Drive litigation strategy and outcomes in a dynamic P&C environment, leading a team to enhance operational effectiveness and improve policyholder experiences while managing diverse liability and cover...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$141K - $234K *

Lead the charge in healthcare performance improvement by overseeing project delivery, managing client relationships, and mentoring a team of Advisory consultants to ensure successful, high-quality out...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $192K *

Engage healthcare providers and drive commercial performance in a defined territory. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative therapi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Help us manage diverse projects that drive strategic growth and collaboration across teams. As a key member of the EPMO, you'll ensure project success through effective stakeholder management and cont...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$190K - $262K *

Join us to ensure high-quality radiation therapy through expert oversight, compliance, and innovative practices. Collaborate with a dedicated team to enhance patient safety and deliver exceptional car...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$123K - $169K *

Elevate healthcare data integration by leading client engagements, optimizing EHR extracts, and providing strategic guidance. Utilize your SQL expertise to ensure data accuracy and foster strong clien...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$88K - $140K *

Drive the development of predictive analytics models to enhance digital assessment operations, collaborating across teams to optimize decision-making and reduce costs while supporting strategic goals...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$135K - $160K *

Drive clinical data management excellence by leading strategies, ensuring data integrity, and collaborating across functions to support successful clinical trials and regulatory submissions in a dynam...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$112K - $149K *

Join a team that's dedicated to providing legal support in mortgage servicing. You'll ensure compliance with regulations, draft essential documents, and collaborate with operational teams to minimize...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$252K - $315K *

Drive innovation in interventional psychiatry by developing evidence-based programs and protocols. Collaborate with clinical teams to enhance patient outcomes and ensure compliance with regulatory sta...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Unlock growth potential by managing strategic accounts and cultivating executive relationships. Drive revenue through tailored strategies and consultative selling, while aligning cross-functional team...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $158K *

Join our team as an SAP EHS Dangerous Goods Specialist, where you'll lead the configuration and support of critical processes, ensuring compliance with global regulations while collaborating across fu...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $180K *

Lead strategic health plan implementations and optimize client solutions. Drive cross-functional collaboration, manage complex projects, and enhance operational workflows to ensure successful launches...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$250K - $300K *

Oversee and deliver exceptional diagnostic imaging services remotely, focusing on evening shifts. Collaborate within a dynamic team while managing varied inpatient and outpatient cases to support pati...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$72K - $94K *

Transform patient access operations by leading centralized support functions, optimizing workflows, and enhancing service quality across multiple regions. Drive continuous improvement and develop lead...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.