Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Manager, Third Party Data Governance
$120K - $145K *
Shape the future of data governance by leading a team to manage third-party data compliance, ensuring operational excellence and regulatory adherence while fostering collaboration across business unit...
Today
Senior Product Owner (HYBRID - LOCAL CANDIDATES ONLY, DALLAS TX)
$110K - $130K *
Unlock potential by leading Agile delivery teams and managing product backlogs. Collaborate with stakeholders to translate business needs into actionable user stories, ensuring alignment with strategi...
6 days ago
Senior Fullstack Engineer, Mortgage Fulfillment AI
$164K - $262K *
Advance your career by designing and operating AI systems for mortgage Fulfillment. Lead architecture, build evaluation frameworks, and ensure reliability while collaborating with cross-functional tea...
1 week ago
Associate Director, Methods and Data Standards
$125K - $145K *
Shape the future of data governance by leading methods and standards across enterprise systems. Collaborate with teams to define quality rules and documentation, ensuring consistency and excellence in...
6 days ago
Manager, Strategic Sourcing - Indirect (Technology)
$111K - $130K *
Grow a high-performing sourcing team while executing strategic initiatives across indirect spend categories. Collaborate cross-functionally to enhance supplier performance and drive operational effici...
5 days ago
Psychiatric Complaints and Grievances Specialist (Remote)
$80K - $95K *
Lead the clinical review and resolution of psychiatric complaints, enhancing care quality across the network. Collaborate with clinical teams, investigate cases, and provide direct patient care, ensur...
2 weeks ago
Director, Copay & Affordability
$199K - $269K *
Shape patient affordability strategies by leading a dynamic team focused on co-pay programs and innovative solutions. Collaborate cross-functionally to enhance operations, optimize performance, and dr...
Reposted 3 days ago
Manager/Senior Manager, Autonomous Enterprise Consulting
$135K - $160K *
Transform client businesses by leading AI strategy and implementation. Drive impactful consulting engagements, build trusted relationships, and leverage emerging technologies to deliver measurable out...
1 week ago
$100K - $120K *
Contribute to US HR operations by ensuring compliance with employment laws, managing employee data, and supporting onboarding/offboarding processes while collaborating with global HR teams for seamles...
Reposted 2 weeks ago
Account Specialist (Bedford, NH)
$160K - $192K *
Transform healthcare engagement by driving commercial performance and building strong relationships with providers. Collaborate cross-functionally to support product launches and ensure patient access...
1 week ago
Data Engineer (Supply Chain) - Clearance Required
$108K - $160K *
Optimize data integration and analysis for supply chain decisions, focusing on parts, procurement, and risk data. Collaborate with experts to identify constraints and enhance workflows, ensuring trace...
2 weeks ago
Pathology Coder III - Remote - 140825
$78K - $103K *
Champion accurate coding by interpreting diagnoses and resolving claim errors in this remote role. Leverage your expertise to ensure compliance with CPT, ICD-10, and HCPCS standards while collaboratin...
Reposted yesterday
$61K - $104K *
Engage in impactful public health data analysis, utilizing quantitative skills and epidemiological knowledge to enhance surveillance programs and support critical health initiatives...
Today
Senior Copywriter, Promotional Medical Writing
$80K - $100K *
Shape the future of medical communications by crafting high-quality, scientifically accurate content. Collaborate with diverse teams to deliver impactful resources that meet client needs while mentori...
Yesterday
Senior Project Manager, Promotional Medical Education
$90K - $100K *
Accelerate progress at a dynamic agency by leading complex client campaigns. Manage project scope, timelines, and budgets while collaborating with cross-functional teams to deliver high-quality result...
Reposted 1 week ago
Associate Director, Regional Marketing (Midwest Region)
$120K - $145K *
Join a team that's driving regional marketing initiatives in hematology and oncology. Engage with key thought leaders, execute strategic plans, and leverage local opportunities to enhance brand presen...
3 weeks ago
Nurse Practitioner / Physician Assistant - California
$140K - $150K *
Partner with us to deliver compassionate, whole-person care for patients with substance use disorders through our innovative telehealth platform, ensuring effective treatment and support in a fully re...
Yesterday
Lead Solutions Architect - DERMS
$103K - $154K *
Unlock your potential as a vital member of a client-focused team, leveraging your expertise to drive successful pre-sales engagements, solutions delivery, and client management in the dynamic utility...
Reposted 6 days ago
Lead Solutions Architect - DERMS
$103K - $154K *
Innovate and lead technical solutions for utility challenges, driving strategic growth through effective pre-sales engagement and deep collaboration with clients and internal teams to deliver tailored...
Reposted 2 weeks ago
Senior Regional Pharmacy Consultant
$95K - $115K *
Join a dynamic team as a Senior Regional Pharmacy Consultant, driving client growth and retention through strategic pharmacy benefits expertise. Collaborate with market leaders and provide consultativ...
1 week ago
$85K - $90K *
Unlock potential by leading product development and analytics solutions for K-12 education. Collaborate with users to translate needs into actionable insights, ensuring data-driven decision-making and...
3 weeks ago
Leader, Solutions Engineer, Splunk
$209K - $275K *
Elevate your career by leading and developing a high-performing Solutions Engineering team. Drive strategic alignment across functions, foster technical excellence, and implement innovative practices...
Reposted 1 week ago
$170K - $195K *
Elevate revenue growth by building strong relationships with law firms and corporations. Drive new business development through consultative sales, leveraging industry insights and collaboration with...
1 week ago
Associate Director, Product Quality
$117K - $189K *
Join a team that's shaping the future of pharmaceutical quality by leading compliance initiatives and building a robust Quality Management System to support innovative therapies in a dynamic, collabor...
2 weeks ago
Assistant Chief Finance Officer
$100K - $120K *
Shape the future of financial leadership by overseeing accounting functions, ensuring compliance, and driving strategic initiatives to enhance financial performance and reporting accuracy within the o...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.