Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

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$120K - $145K *

Shape the future of data governance by leading a team to manage third-party data compliance, ensuring operational excellence and regulatory adherence while fostering collaboration across business unit...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by leading Agile delivery teams and managing product backlogs. Collaborate with stakeholders to translate business needs into actionable user stories, ensuring alignment with strategi...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$164K - $262K *

Advance your career by designing and operating AI systems for mortgage Fulfillment. Lead architecture, build evaluation frameworks, and ensure reliability while collaborating with cross-functional tea...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$125K - $145K *

Shape the future of data governance by leading methods and standards across enterprise systems. Collaborate with teams to define quality rules and documentation, ensuring consistency and excellence in...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$111K - $130K *

Grow a high-performing sourcing team while executing strategic initiatives across indirect spend categories. Collaborate cross-functionally to enhance supplier performance and drive operational effici...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Technical Services

$80K - $95K *

Lead the clinical review and resolution of psychiatric complaints, enhancing care quality across the network. Collaborate with clinical teams, investigate cases, and provide direct patient care, ensur...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$199K - $269K *

Shape patient affordability strategies by leading a dynamic team focused on co-pay programs and innovative solutions. Collaborate cross-functionally to enhance operations, optimize performance, and dr...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Transform client businesses by leading AI strategy and implementation. Drive impactful consulting engagements, build trusted relationships, and leverage emerging technologies to deliver measurable out...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Contribute to US HR operations by ensuring compliance with employment laws, managing employee data, and supporting onboarding/offboarding processes while collaborating with global HR teams for seamles...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $192K *

Transform healthcare engagement by driving commercial performance and building strong relationships with providers. Collaborate cross-functionally to support product launches and ensure patient access...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$108K - $160K *

Optimize data integration and analysis for supply chain decisions, focusing on parts, procurement, and risk data. Collaborate with experts to identify constraints and enhance workflows, ensuring trace...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$78K - $103K *

Champion accurate coding by interpreting diagnoses and resolving claim errors in this remote role. Leverage your expertise to ensure compliance with CPT, ICD-10, and HCPCS standards while collaboratin...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$61K - $104K *

Engage in impactful public health data analysis, utilizing quantitative skills and epidemiological knowledge to enhance surveillance programs and support critical health initiatives...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$80K - $100K *

Shape the future of medical communications by crafting high-quality, scientifically accurate content. Collaborate with diverse teams to deliver impactful resources that meet client needs while mentori...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$90K - $100K *

Accelerate progress at a dynamic agency by leading complex client campaigns. Manage project scope, timelines, and budgets while collaborating with cross-functional teams to deliver high-quality result...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Join a team that's driving regional marketing initiatives in hematology and oncology. Engage with key thought leaders, execute strategic plans, and leverage local opportunities to enhance brand presen...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $150K *

Partner with us to deliver compassionate, whole-person care for patients with substance use disorders through our innovative telehealth platform, ensuring effective treatment and support in a fully re...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$103K - $154K *

Unlock your potential as a vital member of a client-focused team, leveraging your expertise to drive successful pre-sales engagements, solutions delivery, and client management in the dynamic utility...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Business Services

$103K - $154K *

Innovate and lead technical solutions for utility challenges, driving strategic growth through effective pre-sales engagement and deep collaboration with clients and internal teams to deliver tailored...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$95K - $115K *

Join a dynamic team as a Senior Regional Pharmacy Consultant, driving client growth and retention through strategic pharmacy benefits expertise. Collaborate with market leaders and provide consultativ...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$85K - $90K *

Unlock potential by leading product development and analytics solutions for K-12 education. Collaborate with users to translate needs into actionable insights, ensuring data-driven decision-making and...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$209K - $275K *

Elevate your career by leading and developing a high-performing Solutions Engineering team. Drive strategic alignment across functions, foster technical excellence, and implement innovative practices...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$170K - $195K *

Elevate revenue growth by building strong relationships with law firms and corporations. Drive new business development through consultative sales, leveraging industry insights and collaboration with...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$117K - $189K *

Join a team that's shaping the future of pharmaceutical quality by leading compliance initiatives and building a robust Quality Management System to support innovative therapies in a dynamic, collabor...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Shape the future of financial leadership by overseeing accounting functions, ensuring compliance, and driving strategic initiatives to enhance financial performance and reporting accuracy within the o...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.