Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Vice President, Head of Asset Management
$180K - $220K *
Champion the long-term performance of a renewable energy portfolio by overseeing operations, optimizing revenue, and ensuring compliance. Lead third-party management and drive strategic initiatives to...
3 weeks ago
Senior Director, Clinical Diagnostics and Precision Medicine
$242K - $403K *
Lead global companion diagnostics strategy, integrating diagnostic plans with clinical development and regulatory objectives. Drive execution across therapeutic programs, ensuring alignment with patie...
2 weeks ago
$120K - $145K *
Transform healthcare data solutions by designing scalable architectures, optimizing data pipelines, and ensuring compliance with regulations. Collaborate with cross-functional teams to deliver high-qu...
Reposted 2 days ago
Sr. Program Manager (Healthcare)
$120K - $140K *
Engage in leading complex, cross-functional programs for healthcare clients. Drive strategic initiatives, manage risks, and enhance stakeholder communication while delivering impactful results in a dy...
4 weeks ago
Adult Nutrition Acute Care Specialist - Dallas-Fort Worth
$61K - $122K *
Join a team that's driving impactful sales strategies for leading nutrition brands. You will engage with healthcare professionals and expand market share through clinical insights and strong relations...
Reposted 2 weeks ago
$75K - $110K *
Optimize the claims resolution process for commercial property and casualty claims. Collaborate with internal teams and stakeholders to enhance claims handling efficiency and effective communication...
Reposted 1 week ago
Principal Applied Scientist, Generative AI
$195K - $312K *
Zillow is seeking a Principal Applied Scientist to join the Agentic AI team, focusing on developing advanced multimodal technologies for understanding homes. The role involves designing and prototypin...
Reposted 1 week ago
Customer Success Manager, Federal Accounts
$160K - $180K *
Empower customer success by owning post-sale experiences, driving onboarding, adoption, and renewals. Collaborate with cross-functional teams to ensure every user thrives, turning initial deployments...
Yesterday
$213K - $243K *
Champion the development of a robust commercial data strategy, ensuring high-quality, AI-ready data solutions that drive impactful decision-making and enhance commercial performance across the organiz...
3 weeks ago
$110K - $130K *
Elevate your career by designing and automating GRC systems that enhance compliance visibility and efficiency. Collaborate with cross-functional teams to implement AI-powered solutions, ensuring strea...
Reposted yesterday
VP, Global Head of Commercial Transactions
$227K - $315K *
Lead global commercial legal efforts, overseeing seasoned attorneys in negotiating complex technology and commercial agreements. Drive strategy and collaboration for scalable growth while ensuring leg...
Reposted 4 weeks ago
$172K - $215K *
Advance your career by leading software development initiatives, driving architecture design, and optimizing performance in a collaborative environment. Engage with cross-functional teams to deliver s...
Yesterday
EHS Specialist- Environment, Health & Safety
$80K - $150K *
Shape the future of safety in a dynamic environment by developing and enhancing EHS programs. Collaborate across teams to foster a culture of safety and compliance, ensuring adherence to regulations w...
3 days ago
Senior UX Researcher, Quantitative
$120K - $145K *
Lead quantitative user research across product lines, shaping strategy and answering critical questions with data-driven insights. Collaborate with teams to prioritize research that mitigates risk and...
Yesterday
$87K - $157K *
Unlock compliance excellence by managing auditing, monitoring, and reporting processes to ensure adherence to regulatory standards and enhance operational efficiency across contracts and collaboration...
1 month ago
Director, Field Medical Affairs, West Coast
$160K - $190K *
Champion a national team of Medical Science Liaisons focused on obesity, driving strategy and KOL engagement. Lead cross-functional collaboration and ensure compliance while developing high-performing...
Reposted 2 days ago
$175K - $195K *
Lead the charge in shaping enterprise data architecture, ensuring scalable, secure access across systems. Collaborate with engineering teams to deliver impactful data solutions that drive business val...
Yesterday
Clinical Care Leader - Aberdeen Medical Center - Med/Surg - Full Time
$76K - $114K *
Join a team that's dedicated to providing exceptional patient care while collaborating with healthcare professionals. Utilize your nursing expertise to lead and coordinate care in a dynamic medical/su...
2 days ago
Project Manager II, dermatology and rheumatology CRO,USA
$95K - $115K *
Champion project success by leading clinical trials from initiation to closure, ensuring compliance with budgets, timelines, and regulations while fostering collaboration among stakeholders and team m...
Yesterday
$120K - $150K *
Accelerate progress at the forefront of newborn health by leading strategic initiatives, managing multi-country programs, and driving impactful interventions to reduce neonatal mortality and stillbirt...
1 week ago
Executive Director, Translational Medicine & Pediatric Planning
$246K - $332K *
Drive pediatric development strategy by integrating clinical insights and regulatory commitments across multiple therapeutic areas, ensuring effective execution from candidate transition to post-marke...
2 weeks ago
Client Director- US West (Professional Services Sales)
$132K - $199K *
Champion client success by driving Professional Services sales and revenue generation. Collaborate across North America to enhance client relationships and maximize value through effective solution im...
2 weeks ago
Senior Construction Manager -Cheyenne, WY
$100K - $120K *
Lead major construction projects from inception to completion, ensuring compliance, quality control, and effective communication among stakeholders. Collaborate with teams to meet deadlines and exceed...
Reposted yesterday
Senior Construction Manager -Cheyenne, WY
$100K - $120K *
Transform the construction landscape by leading projects from planning through execution, managing schedules, budgets, and compliance, while mentoring teams and ensuring quality and communication with...
Reposted 4 days ago
Strategy & Ops Lead, Applied AI
$110K - $130K *
Optimize internal tooling ecosystems to enhance operational efficiency. Collaborate with engineering to develop AI-driven solutions and automate workflows that streamline team processes and enable sca...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.