Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Director of Account Management
$150K - $180K *
Lead a dynamic account management team, driving strategic relationships with major health systems. Foster high-touch engagement, ensuring customer success and operational excellence while directly man...
2 weeks ago
$110K - $130K *
Unlock potential by leading sales strategies in the renewable energy sector. Collaborate with cross-functional teams to engage clients, driving sales growth and building impactful relationships while...
Reposted 3 weeks ago
$130K - $160K *
Develop innovative measurement solutions by leveraging data science expertise to solve complex marketing challenges. Collaborate closely with customers and cross-functional teams to deliver insights...
4 weeks ago
Regional Director, Clinical Sales - Central
$150K - $180K *
Transform the clinical sales landscape by leading a regional team to drive utilization growth, enhance patient treatment metrics, and foster cross-functional collaboration for commercial success in in...
4 weeks ago
Senior Case Manager RN - Oncology (Remote)
$79K - $127K *
Partner with us to deliver comprehensive case management services, ensuring quality care and optimal health outcomes for members with complex needs. Collaborate with healthcare teams to develop and im...
3 weeks ago
Vice President Management Services
$205K - $380K *
Drive transformative supply chain initiatives, providing strategic leadership and operational oversight to enhance efficiency and best practices across client hospitals. Collaborate with C-suite execu...
Yesterday
Director of Strategic Accounts - U.S. Southeast Education
$139K - $213K *
Grow your career with a dynamic team focused on driving strategic sales in the education sector. Leverage your expertise to engage C-suite executives, manage complex sales cycles, and exceed quotas wh...
2 weeks ago
$70K - $115K *
Empower your career by joining a dynamic team focused on healthcare compliance auditing. Utilize your analytical skills to drive impactful audits and contribute to client deliverables while receiving...
1 week ago
Study Manager - Infectious Disease
$95K - $115K *
Lead the charge in managing interdisciplinary clinical research studies, ensuring compliance with GCP and regulatory requirements while driving project delivery, quality, and financial performance. Bu...
2 weeks ago
$70K - $106K *
Champion patient care by coordinating and delivering occupational therapy services to improve health outcomes, engaging with interdisciplinary teams to develop tailored treatment programs for diverse...
Reposted 2 weeks ago
$90K - $110K *
Deliver impactful data insights by transforming complex datasets into actionable analytics. Collaborate with stakeholders to enhance decision-making and support advanced analytics initiatives within a...
2 weeks ago
Senior Contracts Administrator
$88K - $154K *
Shape the future of contract administration by leading complex negotiations, ensuring compliance, and mitigating risks. Collaborate with cross-functional teams to drive successful outcomes in high-sta...
1 week ago
Enterprise Account Executive, Ohio Valley
$280K - $300K *
Advance your career with a high-impact sales role focused on driving new business and expanding relationships within large enterprise accounts, leveraging cutting-edge AI technology to deliver measura...
3 weeks ago
Director of Customer Onboarding
$130K - $150K *
Join a team that's dedicated to enhancing customer experiences by leading onboarding initiatives, managing cross-functional collaboration, and driving process improvements to ensure timely program lau...
3 weeks ago
Principal Product Manager, Security
$238K - $357K *
Transform security strategy as a Principal Product Manager, bridging technical expertise and customer needs. Collaborate with cross-functional teams to prioritize security features, ensuring usability...
3 weeks ago
Customer Success Manager - LegalFiles
$100K - $120K *
Engage with enterprise clients to drive product adoption and maximize value from legal tech solutions. Act as a trusted advisor, translating customer needs into actionable strategies while ensuring a...
1 week ago
$73K - $91K *
Lead compassionate patient care as a Registered Nurse, collaborating with interdisciplinary teams to enhance health outcomes. Thrive in a supportive environment that values teamwork, professionalism...
6 days ago
$110K - $130K *
Innovate in cancer research by designing and deploying advanced AI and machine learning solutions. Collaborate with cross-functional teams to develop multimodal models integrating diverse clinical dat...
Yesterday
$120K - $145K *
Lead the charge in advancing enterprise automation capabilities, driving quality engineering innovation, and influencing strategic decisions across a rapidly growing organization, enhancing software r...
Reposted 1 week ago
$66K - $102K *
Optimize client solutions by leveraging SAP FICO expertise to analyze, design, and implement financial processes. Collaborate with teams to enhance system functionality and ensure seamless integration...
Today
Project Manager - Construction & Medical Imaging Installs - Washington DC - Field / Travel
$107K - $147K *
Empower your career by managing complex imaging equipment projects, fostering key relationships, and ensuring timely delivery and installation across healthcare environments. Drive success through eff...
2 weeks ago
$81K - $100K *
Deliver exceptional client service by managing strategic accounts, driving retention, and fostering growth. Collaborate with cross-functional teams to address customer needs and expand business opport...
2 weeks ago
Strategic Financial Analyst - Corporate Strategy & Development
$128K - $170K *
Empower executive leadership with strategic financial insights to drive growth initiatives. Collaborate on M&A, pricing, and R&D investments while delivering actionable recommendations in a fast-paced...
Reposted 4 weeks ago
$160K - $200K *
Transform the communications landscape by building a dynamic team that drives brand relevance through strategic earned media, influencer relations, and corporate communications, ensuring a consumer-fi...
3 weeks ago
$130K - $216K *
Lead complex healthcare data initiatives by managing teams, translating business needs into technical solutions, and ensuring data quality and integration. Collaborate with stakeholders to drive analy...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.