Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

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$88K - $105K *

Transform client marketing strategies by leading integrated campaigns, translating data into actionable insights, and driving measurable results. Collaborate cross-functionally while mentoring junior...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$68K - $93K *

Join a team that's dedicated to driving sales and enhancing customer relationships in the animal health sector. Utilize innovative strategies and digital tools to maximize performance and deliver exce...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$104K - $130K *

Empower growth by transforming complex data into actionable insights. Collaborate with senior leaders to build analytical tools and models that drive strategic decisions, while enhancing operational e...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Transform enterprise learning by leading a team to design impactful solutions. Drive employee development, align training with business goals, and optimize learning technologies for enhanced performan...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$153K - $290K *

Transform drug discovery by leading a dynamic team in medicinal chemistry, driving innovative small-molecule candidates from concept to IND-ready status while fostering collaboration across a global n...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$210K - $230K *

Lead the charge in developing enterprise pricing strategies that optimize profitability and drive growth across diverse service sectors, ensuring alignment with market conditions and client needs whil...

RemoteRemote

3 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$78K - $168K *

Drive health outcomes by conducting in-home evaluations, building trust with patients, and providing personalized care. Travel extensively to meet diverse needs, ensuring comprehensive health assessme...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$204K - $229K *

Empower a dynamic consulting team by driving growth strategies, securing projects, and fostering client relationships. Lead initiatives in civic innovation and mobility while mentoring talent and enha...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$240K - $330K *

Pioneer growth in the healthcare sector by driving new business and cultivating strong client relationships. Utilize expert sales skills to oversee complex deals from prospecting to closing in a consu...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$113K - $188K *

Champion adolescent health initiatives by providing strategic guidance and support to federal agencies, enhancing youth engagement, and implementing evidence-based programs to improve outcomes for ado...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$80K - $92K *

Drive the resolution of technical support escalations as a key Tier 2 expert, leveraging your skills to troubleshoot issues, foster collaboration within teams, and enhance workflows in a dynamic envir...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Technical Services

$111K - $167K *

Join a team that's driving healthcare transformation by leading client integration initiatives. Collaborate across departments to ensure seamless transitions, operational readiness, and long-term succ...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$117K - $160K *

Lead the charge in underwriting E&S commercial property and casualty accounts. Manage risk assessments, develop competitive quotes, and collaborate with carriers to optimize profitability while achiev...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$160K - $192K *

Accelerate commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to enhance patient access and support innovative therapies in a dyn...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $154K *

Shape the future of finance by owning financial planning and analysis for Consumer operations, driving efficiency, and enhancing resource allocation through data-driven insights across a dynamic growt...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$183K - $216K *

Champion global employment law compliance by providing expert legal counsel across diverse HR matters, managing performance issues, and navigating international regulations while supporting innovative...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $160K *

Transform product security by leading strategy, conducting threat modeling, and collaborating across teams to ensure secure design and compliance. Drive innovation in security practices while mentorin...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Transform eDiscovery management by driving operational excellence, ensuring timely project delivery, and enhancing workflow efficiency. Collaborate with stakeholders to uphold quality standards and fo...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$175K - $210K *

Champion the execution of a comprehensive medical affairs plan for renal cancer theranostics, driving cross-functional alignment and strategic initiatives to enhance patient outcomes and advance clini...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$250K - $300K *

Explore a rewarding career as a Diagnostic Radiologist, supporting growth in Wilkes-Barre and Scranton. Join a respected practice with modern technology, excellent procedural volume, and opportunities...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $140K *

Empower patient care by providing clinical support and training to surgical teams. Collaborate closely with healthcare professionals to ensure optimal outcomes and maintain equipment standards while m...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$74K - $104K *

Join our team to deliver compassionate dialysis care, ensuring patient safety and comfort. Collaborate with clinicians in a fast-paced environment, utilizing your critical thinking skills to enhance p...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Shape the future of healthcare revenue management by leading IDR processes, ensuring compliance, and driving data-informed improvements while mentoring a team of analysts to optimize workflows and enh...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Shape the future of enterprise-scale cybersecurity by leading vulnerability management initiatives. Drive program strategy, enhance client relationships, and mentor teams to achieve measurable risk re...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Drive governance and controllership for LTC actuarial models, ensuring compliance and effective controls. Collaborate with cross-functional teams to enhance processes and documentation, supporting mod...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.