Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Program Engineer, IT Services & Cloud Operations
$120K - $150K *
Drive complex federal platform initiatives, enhancing security, compliance, and infrastructure through innovative engineering solutions and cross-functional leadership...
Reposted 4 weeks ago
Senior Director, Full-stack Engineer (Remote-Eligible) - Global Payment Network
$286K - $326K *
Empower high-performing teams to innovate banking solutions in the cloud. Drive technical strategy, coach engineers, and enhance delivery for a resilient, scalable platform. Foster a culture of contin...
4 weeks ago
$125K - $150K *
Accelerate account management strategy and execution for premier accounts. Strengthen relationships through planning, product penetration, and high-quality execution while collaborating across teams t...
3 days ago
National Account Director, Community Oncology
$245K - $290K *
Champion strategic relationships in community oncology to enhance market access for innovative therapies. Drive account strategies, negotiate contracts, and collaborate cross-functionally to ensure op...
3 days ago
EverHealth - Product Manager: RCM (Remote, US)
$100K - $120K *
Lead the charge in transforming Revenue Cycle Management through automation, enhancing efficiency and user experience. Collaborate with cross-functional teams to deliver impactful solutions that strea...
1 week ago
$80K - $95K *
Shape the future of digital experiences by designing intuitive, high-performing web interfaces. Collaborate cross-functionally to elevate brand identity and drive user engagement through exceptional U...
2 weeks ago
National Medical Director, Enterprise Partnerships, Remote
$210K - $250K *
Transform healthcare delivery by leading a team of Medical Directors and Clinical Directors, driving clinical strategy and performance excellence across portfolios while fostering relationships and in...
1 week ago
$80K - $85K *
Drive your engineering career while learning the intricate design processes of commercial buildings. Collaborate with senior staff, engage in diverse projects, and explore specialization paths as part...
Reposted 3 weeks ago
Epic Clinical Sr. Reporting Business Analyst
$95K - $115K *
Unlock potential by leading analytics initiatives, transforming data into actionable insights, and mentoring junior analysts. Collaborate with stakeholders to enhance reporting solutions and drive ope...
2 weeks ago
$180K - $220K *
Lead the sales strategy for a healthcare Payer business unit, driving market penetration, revenue growth, and client satisfaction. Collaborate with leadership to shape go-to-market strategies and buil...
Today
$95K - $115K *
Unlock potential by shaping innovative solutions for Opioid Treatment Programs and Medication Assisted Treatment. Collaborate with clients and teams to translate complex needs into actionable product...
4 weeks ago
$188K - $245K *
Shape innovative user experiences by leading design initiatives, mentoring teams, and driving strategic solutions in a fast-paced environment. Collaborate across functions to elevate design quality an...
4 weeks ago
Director, Business Strategy and Operations, Global Clinical Development Operations (GCDO)
$192K - $288K *
Join us as a strategic partner in global clinical development operations, driving workforce planning, budget management, and continuous improvement initiatives. Collaborate with leadership to enhance...
Yesterday
Senior Director, Process Redesign Lead
$150K - $235K *
Join a team that's redefining business processes through digital transformation. Lead cross-functional initiatives, ensuring scalable and standardized practices that align with strategic goals while f...
1 week ago
Director, Market & Network Strategy
$163K - $214K *
Lead the charge in defining strategic market presence and network design. Drive investment decisions by analyzing demand, competition, and demographics to optimize facility configurations across multi...
6 days ago
$120K - $150K *
Unlock operational excellence by leading multi-site Ambulatory Surgery Centers. Drive growth strategies, optimize performance, and foster strong partnerships with physician leaders while managing sign...
Reposted 1 week ago
$133K - $209K *
Lead the charge in optimizing deal structures and contract management, collaborating with cross-functional teams to streamline workflows and enhance the sales process. Your analytical skills will driv...
1 week ago
$145K - $160K *
Lead the charge in transforming member support by defining strategy, enhancing team performance, and integrating AI solutions. Drive operational excellence while fostering a culture of empathy and acc...
3 days ago
Account Specialist (Worcester, MA)
$160K - $192K *
Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...
1 week ago
$150K - $180K *
Join us to lead innovative AI projects, driving enterprise-scale solutions centered on Generative AI and the Google Cloud ecosystem. Your expertise will shape complex deployments and foster client par...
1 month ago
Hemostasis Sales Specialist - Atlanta / Charlotte Region
$99K - $136K *
Champion strategic growth in Hemostasis solutions by leading complex sales cycles, cultivating executive relationships, and driving market share expansion through innovative automation and informatics...
2 weeks ago
Health Plan Partnerships Manager
$100K - $115K *
Elevate your career by driving growth and operations in health plan partnerships. This role combines sales enablement and partner operations, directly impacting revenue through strategic collaboration...
2 weeks ago
Director, Implementation & Build
$134K - $150K *
Lead the charge in optimizing customer onboarding by managing a team of implementation managers, ensuring seamless execution of over 500 concurrent projects while enhancing customer experience and ope...
1 week ago
Clinical Trial Manager II, Dermatology & Rheumatology CRO, USA
$100K - $120K *
Engage with a dynamic CRO to oversee clinical monitoring and enhance site performance. Foster relationships, ensure compliance with regulations, and lead a team in delivering quality outcomes in clini...
Reposted 3 weeks ago
Director of Strategic Accounts - Mid-Market Bay Area
$122K - $187K *
Lead strategic initiatives to drive sales growth and enhance customer relationships within assigned accounts, leveraging your expertise in enterprise software to exceed quotas and deliver tailored sol...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.